Design, synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential-An in vitro and in silico approach
A series of six novel polyesters (P1-P6) were obtained via by direct polycondenzation with hydroxyl functional-appended chromone and curcumin based monomers (M1, M2 and M3) were synthesized and subjected to thermogravimetric and spectroscopic analyses for structural characterization. The synthesized...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Journal of Saudi Chemical Society |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610324000498 |
| _version_ | 1797203108883857408 |
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| author | A. Subramani G. Sasikumar G. Sriram Prasath T.K. Shabeer P. Tamizhdurai Krishna Kumar Yadav Ghadah Shukri Albakri Mohamed Abbas Maha Awjan Alreshidi |
| author_facet | A. Subramani G. Sasikumar G. Sriram Prasath T.K. Shabeer P. Tamizhdurai Krishna Kumar Yadav Ghadah Shukri Albakri Mohamed Abbas Maha Awjan Alreshidi |
| author_sort | A. Subramani |
| collection | DOAJ |
| description | A series of six novel polyesters (P1-P6) were obtained via by direct polycondenzation with hydroxyl functional-appended chromone and curcumin based monomers (M1, M2 and M3) were synthesized and subjected to thermogravimetric and spectroscopic analyses for structural characterization. The synthesized polymers were soluble common organic solvent such as DMF, THF, DMAc and 1-methyl-2-pyrrolidinone (NMP). The molecular weight of the polymers was found to be ranged from 3.390 × 105 – 1.1 × 105 g/mol by GPC-MALS. X-ray diffraction pattern of polyesters indicates P1, P2 and P3 are amorphous in nature, whereas polymer P4, P5, and P6 shows crystalline nature. The receptor VEGFR2 kinase can expand the synthesized molecules into 2D and 3D supramolecular networking through π-π stacking, hydrophobic, and H-bonding interactions. The cell viability effects of polymers on the growth of cell lines A549, HeLa and VERO were evaluated in vitro by MTT assay. The polymer P3 displayed potent anticancer activity compared to the other polymers. Research is undergone in developing curcumin chromone functional polymer as a workable biopolymer which could find value in the present findings. |
| first_indexed | 2024-04-24T08:14:06Z |
| format | Article |
| id | doaj.art-8e61bf5adaa846b59a1ccc8220a1e3af |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-04-24T08:14:06Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-8e61bf5adaa846b59a1ccc8220a1e3af2024-04-17T04:48:45ZengElsevierJournal of Saudi Chemical Society1319-61032024-05-01283101854Design, synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential-An in vitro and in silico approachA. Subramani0G. Sasikumar1G. Sriram Prasath2T.K. Shabeer3P. Tamizhdurai4Krishna Kumar Yadav5Ghadah Shukri Albakri6Mohamed Abbas7Maha Awjan Alreshidi8Department of biochemistry, Dwaraka Doss Goverdhan Doss Vaishnav College, Chennai 600 106, Tamil Nadu, India; Corresponding authors.Department of Chemistry, St. Joseph’s College of Engineering, Chennai 600 119, Tamil Nadu, IndiaDepartment of biochemistry, Dwaraka Doss Goverdhan Doss Vaishnav College, Chennai 600 106, Tamil Nadu, IndiaPG and Research Department of Chemistry, the New College, Chennai-14; Corresponding authors.Department of Chemistry, Dwaraka Doss Goverdhan Doss Vaishnav College (Autonomous) (Affiliated to the University of Madras, Chennai), 833, Gokul Bagh, E.V.R. Periyar Road, Arumbakkam, Chennai 600 106, Tamil Nadu, IndiaFaculty of Science and Technology, Madhyanchal Professional University, Ratibad, Bhopal 462044, India; Environmental and Atmospheric Sciences Research Group, Scientific Research Center, Al-Ayen University, Thi-Qar, Nasiriyah, 64001, IraqDepartment of Teaching and Learning, College of Education and Human development, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi ArabiaElectrical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Saudi ArabiaDepartment of Chemistry, University of Ha’il, Ha’il 81441, Saudi ArabiaA series of six novel polyesters (P1-P6) were obtained via by direct polycondenzation with hydroxyl functional-appended chromone and curcumin based monomers (M1, M2 and M3) were synthesized and subjected to thermogravimetric and spectroscopic analyses for structural characterization. The synthesized polymers were soluble common organic solvent such as DMF, THF, DMAc and 1-methyl-2-pyrrolidinone (NMP). The molecular weight of the polymers was found to be ranged from 3.390 × 105 – 1.1 × 105 g/mol by GPC-MALS. X-ray diffraction pattern of polyesters indicates P1, P2 and P3 are amorphous in nature, whereas polymer P4, P5, and P6 shows crystalline nature. The receptor VEGFR2 kinase can expand the synthesized molecules into 2D and 3D supramolecular networking through π-π stacking, hydrophobic, and H-bonding interactions. The cell viability effects of polymers on the growth of cell lines A549, HeLa and VERO were evaluated in vitro by MTT assay. The polymer P3 displayed potent anticancer activity compared to the other polymers. Research is undergone in developing curcumin chromone functional polymer as a workable biopolymer which could find value in the present findings.http://www.sciencedirect.com/science/article/pii/S1319610324000498Chromone Schiff baseSupramolecular architecture4-arylideneGPC-MALSAnticancer activity |
| spellingShingle | A. Subramani G. Sasikumar G. Sriram Prasath T.K. Shabeer P. Tamizhdurai Krishna Kumar Yadav Ghadah Shukri Albakri Mohamed Abbas Maha Awjan Alreshidi Design, synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential-An in vitro and in silico approach Journal of Saudi Chemical Society Chromone Schiff base Supramolecular architecture 4-arylidene GPC-MALS Anticancer activity |
| title | Design, synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential-An in vitro and in silico approach |
| title_full | Design, synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential-An in vitro and in silico approach |
| title_fullStr | Design, synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential-An in vitro and in silico approach |
| title_full_unstemmed | Design, synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential-An in vitro and in silico approach |
| title_short | Design, synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential-An in vitro and in silico approach |
| title_sort | design synthesis and characterization of novel functional polyesters containing chromone curcumin units and evaluation of its anticancer potential an in vitro and in silico approach |
| topic | Chromone Schiff base Supramolecular architecture 4-arylidene GPC-MALS Anticancer activity |
| url | http://www.sciencedirect.com/science/article/pii/S1319610324000498 |
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