The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS–STING axis is closely i...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383521001775 |
| _version_ | 1798024613867814912 |
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| author | Patrick Kwabena Oduro Xianxian Zheng Jinna Wei Yanze Yang Yuefei Wang Han Zhang Erwei Liu Xiumei Gao Mei Du Qilong Wang |
| author_facet | Patrick Kwabena Oduro Xianxian Zheng Jinna Wei Yanze Yang Yuefei Wang Han Zhang Erwei Liu Xiumei Gao Mei Du Qilong Wang |
| author_sort | Patrick Kwabena Oduro |
| collection | DOAJ |
| description | The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS–STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure, myocardial infarction, cardiac hypertrophy, nonalcoholic fatty liver diseases, aortic aneurysm and dissection, obesity, etc. This is because of the massive loads of damage-associated molecular patterns (mitochondrial DNA, DNA in extracellular vesicles) liberated from recurrent injury to metabolic cellular organelles and tissues, which are sensed by the pathway. Also, the cGAS–STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis, autophagy, and regulate cellular metabolism. Targeting derailed STING signaling has become necessary for chronic inflammatory diseases. Meanwhile, excessive type I interferons signaling impact on cardiovascular and metabolic health remain entirely elusive. In this review, we summarize the intimate connection between the cGAS–STING pathway and cardiovascular and metabolic disorders. We also discuss some potential small molecule inhibitors for the pathway. This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases. |
| first_indexed | 2024-04-11T18:05:25Z |
| format | Article |
| id | doaj.art-8e6204715dac4b8ba94d67097e3822cd |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-04-11T18:05:25Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-8e6204715dac4b8ba94d67097e3822cd2022-12-22T04:10:20ZengElsevierActa Pharmaceutica Sinica B2211-38352022-01-011215075The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapyPatrick Kwabena Oduro0Xianxian Zheng1Jinna Wei2Yanze Yang3Yuefei Wang4Han Zhang5Erwei Liu6Xiumei Gao7Mei Du8Qilong Wang9Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education, Tianjin 301617, ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education, Tianjin 301617, ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education, Tianjin 301617, ChinaInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education, Tianjin 301617, ChinaDepartment of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China; Corresponding authors. Tel./fax: +86 22 83336517.Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education, Tianjin 301617, China; Corresponding authors. Tel./fax: +86 22 83336517.The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS–STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure, myocardial infarction, cardiac hypertrophy, nonalcoholic fatty liver diseases, aortic aneurysm and dissection, obesity, etc. This is because of the massive loads of damage-associated molecular patterns (mitochondrial DNA, DNA in extracellular vesicles) liberated from recurrent injury to metabolic cellular organelles and tissues, which are sensed by the pathway. Also, the cGAS–STING pathway crosstalk with essential intracellular homeostasis processes like apoptosis, autophagy, and regulate cellular metabolism. Targeting derailed STING signaling has become necessary for chronic inflammatory diseases. Meanwhile, excessive type I interferons signaling impact on cardiovascular and metabolic health remain entirely elusive. In this review, we summarize the intimate connection between the cGAS–STING pathway and cardiovascular and metabolic disorders. We also discuss some potential small molecule inhibitors for the pathway. This review provides insight to stimulate interest in and support future research into understanding this signaling axis in cardiovascular and metabolic tissues and diseases.http://www.sciencedirect.com/science/article/pii/S2211383521001775STINGcGASCardiovascular diseasesMetabolic diseasesDamage-associated molecular patternsInflammation |
| spellingShingle | Patrick Kwabena Oduro Xianxian Zheng Jinna Wei Yanze Yang Yuefei Wang Han Zhang Erwei Liu Xiumei Gao Mei Du Qilong Wang The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy Acta Pharmaceutica Sinica B STING cGAS Cardiovascular diseases Metabolic diseases Damage-associated molecular patterns Inflammation |
| title | The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy |
| title_full | The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy |
| title_fullStr | The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy |
| title_full_unstemmed | The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy |
| title_short | The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy |
| title_sort | cgas sting signaling in cardiovascular and metabolic diseases future novel target option for pharmacotherapy |
| topic | STING cGAS Cardiovascular diseases Metabolic diseases Damage-associated molecular patterns Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2211383521001775 |
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