The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

The cGAS–STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS–STING axis is closely i...

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Bibliographic Details
Main Authors: Patrick Kwabena Oduro, Xianxian Zheng, Jinna Wei, Yanze Yang, Yuefei Wang, Han Zhang, Erwei Liu, Xiumei Gao, Mei Du, Qilong Wang
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
STING
cGAS
Cardiovascular diseases
Metabolic diseases
Damage-associated molecular patterns
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521001775

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