Peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathy
AIM: To perform a quantitative analysis of the peripapillary vessel density (VD) and retinal nerve fiber layer (RNFL) thickness changes in patients with early stage of diabetic retinopathy (DR). METHODS: In this case-control study, swept-source optical coherence tomography angiography (SS-OCTA) imag...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2022-09-01
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| Series: | International Journal of Ophthalmology |
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| Online Access: | http://ies.ijo.cn/en_publish/2022/9/20220912.pdf |
| _version_ | 1828118365641637888 |
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| author | Xiang-Ning Wang Xuan Cai Ting-Ting Li Da Long Qiang Wu |
| author_facet | Xiang-Ning Wang Xuan Cai Ting-Ting Li Da Long Qiang Wu |
| author_sort | Xiang-Ning Wang |
| collection | DOAJ |
| description | AIM: To perform a quantitative analysis of the peripapillary vessel density (VD) and retinal nerve fiber layer (RNFL) thickness changes in patients with early stage of diabetic retinopathy (DR). METHODS: In this case-control study, swept-source optical coherence tomography angiography (SS-OCTA) imaging was used to examine diabetic and age-matched healthy subjects. The optic disc HD 6×6 mm2 blood flow imaging scan mode was selected. Automatic software was used to measure the peripapillary VD, capillary vessel density (CVD), and RNLF in an optic nerve head (ONH) filed based on the Garway-Heath map. In addition, the correlation between peripapillary VD, CVD, and RNFL was further investigated. RESULTS: The cohort consisted of 32 healthy individuals and 72 patients with diabetes (34 eyes with no DR and 38 eyes with mild-moderate NPDR). Peripapillary VD decreased in the mild-moderate NPDR group compared to the control group in most regions (P<0.05). Peripapillary CVD and RNFL thickness were significantly lower in the mild-moderate NPDR group in the superior temporal (ST) quadrants (P=0.018, P=0.030). In the correlation analysis of each region, the RNFL thickness in the NS region was positively correlated with the peripapillary VD and CVD (r=0.233, P=0.05; r=0.288, P=0.015). In the TI region, the RNFL thickness was positively correlated with the peripapillary CVD (r=0.237, P=0.047). CONCLUSION: The measurement based on the ONH topographic map may be helpful in detecting functional and structural impairments in DR. The peripapillary VD, CVD and RNFL decrease in early DR, and the RNFL thickness altered in association with the CVD or/and VD in some regions. |
| first_indexed | 2024-04-11T13:31:15Z |
| format | Article |
| id | doaj.art-8e62077c0ce24880a7fb4db49e46d348 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-04-11T13:31:15Z |
| publishDate | 2022-09-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-8e62077c0ce24880a7fb4db49e46d3482022-12-22T04:21:50ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982022-09-011591488149510.18240/ijo.2022.09.1220220912Peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathyXiang-Ning Wang0Xuan Cai1Ting-Ting Li2Da Long3Qiang Wu4Qiang Wu. Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No.600 Yishan Road, Xuhui District, Shanghai 200233, China. qiang.wu@shsmu.edu.cn.Department of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, ChinaDepartment of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, ChinaDepartment of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, ChinaDepartment of Ophthalmology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, ChinaAIM: To perform a quantitative analysis of the peripapillary vessel density (VD) and retinal nerve fiber layer (RNFL) thickness changes in patients with early stage of diabetic retinopathy (DR). METHODS: In this case-control study, swept-source optical coherence tomography angiography (SS-OCTA) imaging was used to examine diabetic and age-matched healthy subjects. The optic disc HD 6×6 mm2 blood flow imaging scan mode was selected. Automatic software was used to measure the peripapillary VD, capillary vessel density (CVD), and RNLF in an optic nerve head (ONH) filed based on the Garway-Heath map. In addition, the correlation between peripapillary VD, CVD, and RNFL was further investigated. RESULTS: The cohort consisted of 32 healthy individuals and 72 patients with diabetes (34 eyes with no DR and 38 eyes with mild-moderate NPDR). Peripapillary VD decreased in the mild-moderate NPDR group compared to the control group in most regions (P<0.05). Peripapillary CVD and RNFL thickness were significantly lower in the mild-moderate NPDR group in the superior temporal (ST) quadrants (P=0.018, P=0.030). In the correlation analysis of each region, the RNFL thickness in the NS region was positively correlated with the peripapillary VD and CVD (r=0.233, P=0.05; r=0.288, P=0.015). In the TI region, the RNFL thickness was positively correlated with the peripapillary CVD (r=0.237, P=0.047). CONCLUSION: The measurement based on the ONH topographic map may be helpful in detecting functional and structural impairments in DR. The peripapillary VD, CVD and RNFL decrease in early DR, and the RNFL thickness altered in association with the CVD or/and VD in some regions.http://ies.ijo.cn/en_publish/2022/9/20220912.pdfvessel densityretinal nerve fiber layerdiabetic retinopathyoctaswept-source |
| spellingShingle | Xiang-Ning Wang Xuan Cai Ting-Ting Li Da Long Qiang Wu Peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathy International Journal of Ophthalmology vessel density retinal nerve fiber layer diabetic retinopathy octa swept-source |
| title | Peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathy |
| title_full | Peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathy |
| title_fullStr | Peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathy |
| title_full_unstemmed | Peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathy |
| title_short | Peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathy |
| title_sort | peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathy |
| topic | vessel density retinal nerve fiber layer diabetic retinopathy octa swept-source |
| url | http://ies.ijo.cn/en_publish/2022/9/20220912.pdf |
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