Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses
Abstract High frequency burst firing is critical in summation of back-propagating action potentials (APs) in dendrites, which may greatly depolarize dendritic membrane potential. The physiological significance of burst firings of hippocampal dentate GCs in synaptic plasticity remains unknown. We fou...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | Molecular Brain |
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| Online Access: | https://doi.org/10.1186/s13041-023-01034-w |
| _version_ | 1797817714976227328 |
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| author | Yoonsub Kim Sooyun Kim Won-Kyung Ho Suk-Ho Lee |
| author_facet | Yoonsub Kim Sooyun Kim Won-Kyung Ho Suk-Ho Lee |
| author_sort | Yoonsub Kim |
| collection | DOAJ |
| description | Abstract High frequency burst firing is critical in summation of back-propagating action potentials (APs) in dendrites, which may greatly depolarize dendritic membrane potential. The physiological significance of burst firings of hippocampal dentate GCs in synaptic plasticity remains unknown. We found that GCs with low input resistance could be categorized into regular-spiking (RS) and burst-spiking (BS) cells based on their initial firing frequency (Finit) upon somatic rheobase current injection, and investigated how two types of GCs differ in long-term potentiation (LTP) induced by high-frequency lateral perforant pathway (LPP) inputs. Induction of Hebbian LTP at LPP synapses required at least three postsynaptic APs at Finit higher than 100 Hz, which was met in BS but not in RS cells. The synaptically evoked burst firing was critically dependent on persistent Na+ current, which was larger in BS than RS cells. The Ca2+ source for Hebbian LTP at LPP synapses was primarily provided by L-type calcium channels. In contrast, Hebbian LTP at medial PP synapses was mediated by T-type calcium channels, and could be induced regardless of cell types or Finit of postsynaptic APs. These results suggest that intrinsic firing properties affect synaptically driven firing patterns, and that bursting behavior differentially affects Hebbian LTP mechanisms depending on the synaptic input pathway. |
| first_indexed | 2024-03-13T08:57:31Z |
| format | Article |
| id | doaj.art-8e622fd781c54a7fac6b5181c45a7817 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-03-13T08:57:31Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-8e622fd781c54a7fac6b5181c45a78172023-05-28T11:31:15ZengBMCMolecular Brain1756-66062023-05-0116112210.1186/s13041-023-01034-wBurst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapsesYoonsub Kim0Sooyun Kim1Won-Kyung Ho2Suk-Ho Lee3Cell Physiology Lab. Department of Physiology, Seoul National University College of MedicineClinical Research Institute, Seoul National University HospitalCell Physiology Lab. Department of Physiology, Seoul National University College of MedicineCell Physiology Lab. Department of Physiology, Seoul National University College of MedicineAbstract High frequency burst firing is critical in summation of back-propagating action potentials (APs) in dendrites, which may greatly depolarize dendritic membrane potential. The physiological significance of burst firings of hippocampal dentate GCs in synaptic plasticity remains unknown. We found that GCs with low input resistance could be categorized into regular-spiking (RS) and burst-spiking (BS) cells based on their initial firing frequency (Finit) upon somatic rheobase current injection, and investigated how two types of GCs differ in long-term potentiation (LTP) induced by high-frequency lateral perforant pathway (LPP) inputs. Induction of Hebbian LTP at LPP synapses required at least three postsynaptic APs at Finit higher than 100 Hz, which was met in BS but not in RS cells. The synaptically evoked burst firing was critically dependent on persistent Na+ current, which was larger in BS than RS cells. The Ca2+ source for Hebbian LTP at LPP synapses was primarily provided by L-type calcium channels. In contrast, Hebbian LTP at medial PP synapses was mediated by T-type calcium channels, and could be induced regardless of cell types or Finit of postsynaptic APs. These results suggest that intrinsic firing properties affect synaptically driven firing patterns, and that bursting behavior differentially affects Hebbian LTP mechanisms depending on the synaptic input pathway.https://doi.org/10.1186/s13041-023-01034-wDentate gyrusGranule cellBurst firingPerforant pathwayLong-term potentiationCalcium channel |
| spellingShingle | Yoonsub Kim Sooyun Kim Won-Kyung Ho Suk-Ho Lee Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses Molecular Brain Dentate gyrus Granule cell Burst firing Perforant pathway Long-term potentiation Calcium channel |
| title | Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses |
| title_full | Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses |
| title_fullStr | Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses |
| title_full_unstemmed | Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses |
| title_short | Burst firing is required for induction of Hebbian LTP at lateral perforant path to hippocampal granule cell synapses |
| title_sort | burst firing is required for induction of hebbian ltp at lateral perforant path to hippocampal granule cell synapses |
| topic | Dentate gyrus Granule cell Burst firing Perforant pathway Long-term potentiation Calcium channel |
| url | https://doi.org/10.1186/s13041-023-01034-w |
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