Procainamide, oxprenolol and amiodarone as antidysrhythmic drugs in myocardial infarction.
Using Holter recordings and based on the principle that most of the survivors of acute myocardial infarction who are going to die suddenly after hospital discharge are those who present ventricular premature beats (VPB), the authors have studied the effect of three different antidysrhythmic drugs -...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
1980-12-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4294 |
| _version_ | 1811195849525428224 |
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| author | J. L. Tuna M. J. Correia V. Corrêa d'Almeida L. Mourão F. Leal da Costa C. Ribeiro |
| author_facet | J. L. Tuna M. J. Correia V. Corrêa d'Almeida L. Mourão F. Leal da Costa C. Ribeiro |
| author_sort | J. L. Tuna |
| collection | DOAJ |
| description |
Using Holter recordings and based on the principle that most of the survivors of acute myocardial infarction who are going to die suddenly after hospital discharge are those who present ventricular premature beats (VPB), the authors have studied the effect of three different antidysrhythmic drugs - procainamide (PA), oxprenolol (OX) and amiodarones. (AMIOD) - in late phase of acute myocardial infarction. All the trials have been controlled Procainamide (47 patients studied), in comparison with placebo (PL), revealed to be effective (a) in supressing and diminishing VPB/hour (p=0.0425), and (b) in maintaining patients with no VPB (PA 89.6% - PL 64.7%). Oxprenolol (27 patients studied), in comparison with placebo, revealed to be effective (a) in maintaining patients with no VPB (p=0.0525), and (b) in avoiding the increase of VPB/hour (p=0.0576). Finally amiodarone (37 patients studied), in comparison with placebo, was effective (a) in maintaining patients with no VPB (AMIOD 50% - PL 39%), (b) in diminishing VPB/hour (AMIOD 29% - PL 9%), and (c) in avoiding the increase of VPB/hour (AMIOD 79% - PL 48%). The authors finish their paper emphasizing that no antidysrhythmic drug should be introduced in clinical practice before being submitted to controlled studies with Holter electrocardiography.
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| first_indexed | 2024-04-12T00:49:22Z |
| format | Article |
| id | doaj.art-8e6531dbeda949d49d6f3d10f3e8aa89 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-12T00:49:22Z |
| publishDate | 1980-12-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-8e6531dbeda949d49d6f3d10f3e8aa892022-12-22T03:54:46ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07581980-12-01210.20344/amp.4294Procainamide, oxprenolol and amiodarone as antidysrhythmic drugs in myocardial infarction.J. L. Tuna0M. J. Correia1V. Corrêa d'Almeida2L. Mourão3F. Leal da Costa4C. RibeiroUTIC. Hospital Santa Maria. Lisboa. PortugalUTIC. Hospital Santa Maria. Lisboa. PortugalUTIC. Hospital Santa Maria. Lisboa. PortugalUTIC. Hospital Santa Maria. Lisboa. PortugalUTIC. Hospital Santa Maria. Lisboa. Portugal Using Holter recordings and based on the principle that most of the survivors of acute myocardial infarction who are going to die suddenly after hospital discharge are those who present ventricular premature beats (VPB), the authors have studied the effect of three different antidysrhythmic drugs - procainamide (PA), oxprenolol (OX) and amiodarones. (AMIOD) - in late phase of acute myocardial infarction. All the trials have been controlled Procainamide (47 patients studied), in comparison with placebo (PL), revealed to be effective (a) in supressing and diminishing VPB/hour (p=0.0425), and (b) in maintaining patients with no VPB (PA 89.6% - PL 64.7%). Oxprenolol (27 patients studied), in comparison with placebo, revealed to be effective (a) in maintaining patients with no VPB (p=0.0525), and (b) in avoiding the increase of VPB/hour (p=0.0576). Finally amiodarone (37 patients studied), in comparison with placebo, was effective (a) in maintaining patients with no VPB (AMIOD 50% - PL 39%), (b) in diminishing VPB/hour (AMIOD 29% - PL 9%), and (c) in avoiding the increase of VPB/hour (AMIOD 79% - PL 48%). The authors finish their paper emphasizing that no antidysrhythmic drug should be introduced in clinical practice before being submitted to controlled studies with Holter electrocardiography. https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4294 |
| spellingShingle | J. L. Tuna M. J. Correia V. Corrêa d'Almeida L. Mourão F. Leal da Costa C. Ribeiro Procainamide, oxprenolol and amiodarone as antidysrhythmic drugs in myocardial infarction. Acta Médica Portuguesa |
| title | Procainamide, oxprenolol and amiodarone as antidysrhythmic drugs in myocardial infarction. |
| title_full | Procainamide, oxprenolol and amiodarone as antidysrhythmic drugs in myocardial infarction. |
| title_fullStr | Procainamide, oxprenolol and amiodarone as antidysrhythmic drugs in myocardial infarction. |
| title_full_unstemmed | Procainamide, oxprenolol and amiodarone as antidysrhythmic drugs in myocardial infarction. |
| title_short | Procainamide, oxprenolol and amiodarone as antidysrhythmic drugs in myocardial infarction. |
| title_sort | procainamide oxprenolol and amiodarone as antidysrhythmic drugs in myocardial infarction |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/4294 |
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