Spheroid Fabrication Using Concave Microwells Enhances the Differentiation Efficacy and Function of Insulin-Producing Cells via Cytoskeletal Changes
Pancreatic islet transplantation is the fundamental treatment for insulin-dependent diabetes; however, donor shortage is a major hurdle in its use as a standard treatment. Accordingly, differentiated insulin-producing cells (DIPCs) are being developed as a new islet source. Differentiation efficienc...
Main Authors: | Yu Na Lee, Hye Jin Yi, Hanse Goh, Ji Yoon Park, Sarah Ferber, In Kyong Shim, Song Cheol Kim |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
|
Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/9/12/2551 |
Similar Items
-
Enhanced Differentiation Capacity and Transplantation Efficacy of Insulin-Producing Cell Clusters from Human iPSCs Using Permeable Nanofibrous Microwell-Arrayed Membrane for Diabetes Treatment
by: In Kyong Shim, et al.
Published: (2022-02-01) -
Recapitulating the Drifting and Fusion of Two-Generation Spheroids on Concave Agarose Microwells
by: Rong Pan, et al.
Published: (2023-07-01) -
Setup of human liver-chips integrating 3D models, microwells and a standardized microfluidic platform as proof-of-concept study to support drug evaluation
by: Benoit Cox, et al.
Published: (2022-08-01) -
Establishment of an In Vivo Xenograft Mouse Model of a Subcutaneous Submillimeter HT-29 Tumor Formed from a Single Spheroid Transplanted Using Radiation-Crosslinked Gelatin Hydrogel Microwell
by: Tomoko Tachibana, et al.
Published: (2021-07-01) -
Numerical Simulation of the Behavior of Toroidal and Spheroidal Multicellular Aggregates in Microfluidic Devices with Microwell and U-Shaped Barrier
by: Maryam Barisam, et al.
Published: (2017-12-01)