Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effect
ABSTRACT A drug delivery system (DDS) with analgesic and antibacterial properties would be desirable for the local control of post-operatory pain and the prevention for surgical site infection (SSI). The objective of the present study was to evaluate the antinociceptive effect of the combination bet...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2018-07-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200601&lng=en&tlng=en |
| _version_ | 1818756766801854464 |
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| author | Vicente Esparza-Villalpando Daniel Chavarria-Bolaños Juan Ramón Zapata-Morales Antonio Vértiz-Hernández Amaury Pozos-Guillén |
| author_facet | Vicente Esparza-Villalpando Daniel Chavarria-Bolaños Juan Ramón Zapata-Morales Antonio Vértiz-Hernández Amaury Pozos-Guillén |
| author_sort | Vicente Esparza-Villalpando |
| collection | DOAJ |
| description | ABSTRACT A drug delivery system (DDS) with analgesic and antibacterial properties would be desirable for the local control of post-operatory pain and the prevention for surgical site infection (SSI). The objective of the present study was to evaluate the antinociceptive effect of the combination between dexketoprofen trometamol (DXT) and chlorhexidine gluconate (CHX) in the formalin pain model. Different doses of CHX were combined with DXT and were locally administered in rats paw simultaneously with 5% formalin dilution. Flinches were documented and the antinociceptive effect was calculated. The area under the curve of each experimental group were calculated and the % of antinociception were compared. The groups of CHX and DXT showed similar antinociceptive effect. The combination groups (DXT-CHX) showed higher antinociceptive effect that the one obtained with individual molecules. Besides the confirmation of DXT local antinociceptive properties, CHX also showed a positive effect; and an additive effect when combined with DXT. |
| first_indexed | 2024-12-18T06:00:16Z |
| format | Article |
| id | doaj.art-8e67e2e7ac9140298fb5fe0de1ae6a96 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-18T06:00:16Z |
| publishDate | 2018-07-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-8e67e2e7ac9140298fb5fe0de1ae6a962022-12-21T21:18:41ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902018-07-0154210.1590/s2175-97902018000217799S1984-82502018000200601Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effectVicente Esparza-VillalpandoDaniel Chavarria-BolañosJuan Ramón Zapata-MoralesAntonio Vértiz-HernándezAmaury Pozos-GuillénABSTRACT A drug delivery system (DDS) with analgesic and antibacterial properties would be desirable for the local control of post-operatory pain and the prevention for surgical site infection (SSI). The objective of the present study was to evaluate the antinociceptive effect of the combination between dexketoprofen trometamol (DXT) and chlorhexidine gluconate (CHX) in the formalin pain model. Different doses of CHX were combined with DXT and were locally administered in rats paw simultaneously with 5% formalin dilution. Flinches were documented and the antinociceptive effect was calculated. The area under the curve of each experimental group were calculated and the % of antinociception were compared. The groups of CHX and DXT showed similar antinociceptive effect. The combination groups (DXT-CHX) showed higher antinociceptive effect that the one obtained with individual molecules. Besides the confirmation of DXT local antinociceptive properties, CHX also showed a positive effect; and an additive effect when combined with DXT.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200601&lng=en&tlng=enAntinociception/effectsFormalin testDexketoprofen trometamolChlorhexidine |
| spellingShingle | Vicente Esparza-Villalpando Daniel Chavarria-Bolaños Juan Ramón Zapata-Morales Antonio Vértiz-Hernández Amaury Pozos-Guillén Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effect Brazilian Journal of Pharmaceutical Sciences Antinociception/effects Formalin test Dexketoprofen trometamol Chlorhexidine |
| title | Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effect |
| title_full | Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effect |
| title_fullStr | Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effect |
| title_full_unstemmed | Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effect |
| title_short | Antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test: an additive effect |
| title_sort | antinociceptive local effect of the combination of dexketoprofen trometamol and chlorhexidine gluconate in a formalin test an additive effect |
| topic | Antinociception/effects Formalin test Dexketoprofen trometamol Chlorhexidine |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200601&lng=en&tlng=en |
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