Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease.
In the course of screening for the anti-Parkinsonian drugs from a library of traditional herbal medicines, we found that the extracts of choi-joki-to and daio-kanzo-to protected cells from MPP+-induced cell death. Because choi-joki-to and daio-kanzo-to commonly contain the genus Glycyrrhiza, we isol...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4069009?pdf=render |
| _version_ | 1818011669627928576 |
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| author | Takahiro Fujimaki Shinji Saiki Etsu Tashiro Daisuke Yamada Mitsuhiro Kitagawa Nobutaka Hattori Masaya Imoto |
| author_facet | Takahiro Fujimaki Shinji Saiki Etsu Tashiro Daisuke Yamada Mitsuhiro Kitagawa Nobutaka Hattori Masaya Imoto |
| author_sort | Takahiro Fujimaki |
| collection | DOAJ |
| description | In the course of screening for the anti-Parkinsonian drugs from a library of traditional herbal medicines, we found that the extracts of choi-joki-to and daio-kanzo-to protected cells from MPP+-induced cell death. Because choi-joki-to and daio-kanzo-to commonly contain the genus Glycyrrhiza, we isolated licopyranocoumarin (LPC) and glycyrurol (GCR) as potent neuroprotective principals from Glycyrrhiza. LPC and GCR markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK. LPC and GCR inhibited MPP+-induced JNK activation through the suppression of reactive oxygen species (ROS) generation, thereby inhibiting MPP+-induced neuronal PC12D cell death. These results indicated that LPC and GCR derived from choi-joki-to and daio-kanzo-to would be promising drug leads for PD treatment in the future. |
| first_indexed | 2024-04-14T06:11:26Z |
| format | Article |
| id | doaj.art-8e68ff495bf54f92957609b5e5b86996 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T06:11:26Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8e68ff495bf54f92957609b5e5b869962022-12-22T02:08:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e10039510.1371/journal.pone.0100395Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease.Takahiro FujimakiShinji SaikiEtsu TashiroDaisuke YamadaMitsuhiro KitagawaNobutaka HattoriMasaya ImotoIn the course of screening for the anti-Parkinsonian drugs from a library of traditional herbal medicines, we found that the extracts of choi-joki-to and daio-kanzo-to protected cells from MPP+-induced cell death. Because choi-joki-to and daio-kanzo-to commonly contain the genus Glycyrrhiza, we isolated licopyranocoumarin (LPC) and glycyrurol (GCR) as potent neuroprotective principals from Glycyrrhiza. LPC and GCR markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK. LPC and GCR inhibited MPP+-induced JNK activation through the suppression of reactive oxygen species (ROS) generation, thereby inhibiting MPP+-induced neuronal PC12D cell death. These results indicated that LPC and GCR derived from choi-joki-to and daio-kanzo-to would be promising drug leads for PD treatment in the future.http://europepmc.org/articles/PMC4069009?pdf=render |
| spellingShingle | Takahiro Fujimaki Shinji Saiki Etsu Tashiro Daisuke Yamada Mitsuhiro Kitagawa Nobutaka Hattori Masaya Imoto Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. PLoS ONE |
| title | Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. |
| title_full | Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. |
| title_fullStr | Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. |
| title_full_unstemmed | Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. |
| title_short | Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. |
| title_sort | identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for parkinson s disease |
| url | http://europepmc.org/articles/PMC4069009?pdf=render |
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