Emerging properties of hydrogels in tissue engineering
Hydrogels are three-dimensional polymeric networks filled with water and mimic tissue environments. Therefore, they are considered optimal to deliver cells and engineer damaged tissues. The hydrogel networks have been significantly modified to endow biochemical functionality with adhesive ligands, g...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-03-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/2041731418768285 |
| _version_ | 1818516582606831616 |
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| author | Jung-Hwan Lee Hae-Won Kim |
| author_facet | Jung-Hwan Lee Hae-Won Kim |
| author_sort | Jung-Hwan Lee |
| collection | DOAJ |
| description | Hydrogels are three-dimensional polymeric networks filled with water and mimic tissue environments. Therefore, they are considered optimal to deliver cells and engineer damaged tissues. The hydrogel networks have been significantly modified to endow biochemical functionality with adhesive ligands, growth factors, or degradable sites that are helpful to drive proper cell functions. Recently, some of the biophysical properties of hydrogels have emerged as key players in dictating cell fate. Beyond static stiffness, time-dependent stress/strain changes in the interaction with cells and the cell-mediated degradation and matrix synthesis have been demonstrated to shape cell status and tissue repair process. We highlight here the emerging biophysical properties of hydrogels that can motivate tissue engineers to design and develop hydrogels optimally for tissue regeneration. |
| first_indexed | 2024-12-11T00:44:15Z |
| format | Article |
| id | doaj.art-8e691aed1bcd428eb5701ae8fc11f027 |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-12-11T00:44:15Z |
| publishDate | 2018-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-8e691aed1bcd428eb5701ae8fc11f0272022-12-22T01:26:49ZengSAGE PublishingJournal of Tissue Engineering2041-73142018-03-01910.1177/2041731418768285Emerging properties of hydrogels in tissue engineeringJung-Hwan Lee0Hae-Won Kim1Department of Biomaterials Science, College of Dentistry, Dankook University, Cheonan, Republic of KoreaDepartment of Nanobiomedical Science & BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, Republic of KoreaHydrogels are three-dimensional polymeric networks filled with water and mimic tissue environments. Therefore, they are considered optimal to deliver cells and engineer damaged tissues. The hydrogel networks have been significantly modified to endow biochemical functionality with adhesive ligands, growth factors, or degradable sites that are helpful to drive proper cell functions. Recently, some of the biophysical properties of hydrogels have emerged as key players in dictating cell fate. Beyond static stiffness, time-dependent stress/strain changes in the interaction with cells and the cell-mediated degradation and matrix synthesis have been demonstrated to shape cell status and tissue repair process. We highlight here the emerging biophysical properties of hydrogels that can motivate tissue engineers to design and develop hydrogels optimally for tissue regeneration.https://doi.org/10.1177/2041731418768285 |
| spellingShingle | Jung-Hwan Lee Hae-Won Kim Emerging properties of hydrogels in tissue engineering Journal of Tissue Engineering |
| title | Emerging properties of hydrogels in tissue engineering |
| title_full | Emerging properties of hydrogels in tissue engineering |
| title_fullStr | Emerging properties of hydrogels in tissue engineering |
| title_full_unstemmed | Emerging properties of hydrogels in tissue engineering |
| title_short | Emerging properties of hydrogels in tissue engineering |
| title_sort | emerging properties of hydrogels in tissue engineering |
| url | https://doi.org/10.1177/2041731418768285 |
| work_keys_str_mv | AT junghwanlee emergingpropertiesofhydrogelsintissueengineering AT haewonkim emergingpropertiesofhydrogelsintissueengineering |