Molecular Mechanisms of Hemoglobin F Induction

Molecular Mechanisms of Hemoglobin F Induction

Show other versions (1)

Hemoglobin F (HbF, α2γ2) is a major contributor to the clinical heterogeneity and ameliorating agent observed in patients with the β-globin disorders including β-thalassemia and sickle cell disease (SCD). During fetal life, HbF is the major hemoglobin but is lar...

Full description

Bibliographic Details
Main Authors:	Najmaldin Saki, Ali Dehghani Fard, Majid Farshdousti Hagh, Mohammad Shahjahani, Saied Kaviani
Format:	Article
Language:	English
Published:	Tehran University of Medical Sciences 2011-10-01
Series:	International Journal of Hematology-Oncology and Stem Cell Research
Subjects:	Hemoglobin F β-thalassemia Expression Induction
Online Access:	http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/20851.pdf&manuscript_id=20851

Similar Items

Molecular Mechanisms of Hemoglobin F Induction
by: Majid Farshdousti Hagh, et al.
Published: (2011-12-01)

Evaluation of Signaling Pathways Involved in γ-Globin Gene Induction Using Fetal Hemoglobin Inducer Drugs
by: Fakher Rahim, et al.
Published: (2013-07-01)

Evaluation of Signaling Pathways Involved in γ-Globin Gene Induction Using Fetal Hemoglobin Inducer Drugs
by: Fakher Rahim, et al.
Published: (2013-09-01)

Thalidomide is more efficient than sodium butyrate in enhancing GATA-1 and EKLF gene expression in erythroid progenitors derived from HSCs with β-globin gene mutation
by: Mohammad Ali Jalali Far, et al.
Published: (2016-04-01)

The Role of Epigenetics in the Induction of Fetal Hemoglobin: A Combination Therapy Approach
by: Mohammad Ahmadvand, et al.
Published: (2014-03-01)

Combined approaches for increasing fetal hemoglobin (HbF) and de novo production of adult hemoglobin (HbA) in erythroid cells from β-thalassemia patients: treatment with HbF inducers and CRISPR-Cas9 based genome editing
by: Alessia Finotti, et al.
Published: (2023-07-01)

Pharmacological Induction of Fetal Hemoglobin in β-Thalassemia and Sickle Cell Disease: An Updated Perspective
by: Rayan Bou-Fakhredin, et al.
Published: (2022-06-01)

Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with <i>Cinchona</i> Alkaloids: Induction of Fetal Hemoglobin Production
by: Cristina Zuccato, et al.
Published: (2021-12-01)

Co-Treatment of Erythroid Cells from β-Thalassemia Patients with CRISPR-Cas9-Based β<sup>0</sup>39-Globin Gene Editing and Induction of Fetal Hemoglobin
by: Lucia Carmela Cosenza, et al.
Published: (2022-09-01)

Effect of hydroxyurea on SP1, LIN28B, IGF2BP3, COL4A5, BCL2, gamma globin genes expression: an in vitro study
by: Akram Agha-Amini Fashami, et al.
Published: (2023-11-01)

Evaluation of Novel Fetal Hemoglobin Inducer Drugs in Treatment of β-Hemoglobinopathy Disorders
by: Fatemeh Salari, et al.
Published: (2013-07-01)

Evaluation of Novel Fetal Hemoglobin Inducer Drugs in Treatment of β-Hemoglobinopathy Disorders
by: Ali Dehghani Fard, et al.
Published: (2013-09-01)

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the <i>Aγ-Globin</i> Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers
by: Cristina Zuccato, et al.
Published: (2023-01-01)

Camperdown hemoglobin associated with beta° thalassemia in a Brazilian child
by: Tania Regina Tozetto-Mendoza, et al.
Published: (2005-09-01)

Xmn1-158 γGVariant in B-Thalassemia Intermediate Patients in South-East of Iran
by: Ebrahim Miri-Moghaddam, et al.
Published: (2017-04-01)

Reporting two hemoglobin J Iran cases, molecular follow-up, or is it insignificant?
by: Amin Solouki, et al.
Published: (2023-05-01)

Induction of Fetal Hemoglobin by Introducing Natural Hereditary Persistence of Fetal Hemoglobin Mutations in the γ-Globin Gene Promoters for Genome Editing Therapies for β-Thalassemia
by: Dian Lu, et al.
Published: (2022-05-01)

Molecular epidemiological investigation of abnormal hemoglobin in Shaokwan region, southern China
by: Hui Yang, et al.
Published: (2022-12-01)

Prevalence and mutations of β-thalassemia trait and abnormal hemoglobins in premarital screening in Çanakkale province, Turkey
by: Uludağ A, et al.
Published: (2016-06-01)

Estimated level of plasma micro RNA-210 in beta thalassemia patients and its relation to hemoglobin F level and disease severity
by: Homam M Sharshera, et al.
Published: (2023-01-01)

Impact of Genetic Polymorphisms in Modifier Genes in Determining Fetal Hemoglobin Levels in Beta-Thalassemia
by: Poonam Tripathi, et al.
Published: (2023-03-01)

The Emerging role of Immunomodulatory Agents in Fetal Hemoglobin Induction
by: Ali Dehghani Fard, et al.
Published: (2012-10-01)

The Emerging role of Immunomodulatory Agents in Fetal Hemoglobin Induction
by: Ali Dehghani-Fard, et al.
Published: (2015-10-01)

Epigenetic modulations on the fetal hemoglobin induction
by: Najmaldin Saki, et al.
Published: (2012-01-01)

Hemoglobin H Disease in Turkey: Experience from Eight Centers
by: Selma Ünal, et al.
Published: (2016-02-01)

HbA2 measurements in β-thalassemia and in other conditions
by: Giovanni Ivaldi, et al.
Published: (2014-09-01)

Quantitation of hemoglobins using Sebia Capillarys-2 capillary electrophoresis (CE) for A1c: Comparison to results using CE for hemoglobins
by: Catherine M. Tucker, et al.
Published: (2023-03-01)

Oxidative instability of hemoglobin E (β26 Glu→Lys) is increased in the presence of free α subunits and reversed by α-hemoglobin stabilizing protein (AHSP): Relevance to HbE/β-thalassemia
by: Michael Brad Strader, et al.
Published: (2016-08-01)

Hemoglobin E Hemoglobinopathy in an Adult from Assam with Unusual Presentation: A Diagnostic Dilemma
by: Sunitha S Kiran, et al.
Published: (2016-07-01)

Simplified hemolysate preparation for identification and quantitation of hemoglobin by electrophoresis
by: C Nopparatana, et al.
Published: (2008-06-01)

Erythroid induction activity of Aquilegia fragrans and Aquilegia pubiflora and identification of compounds using liquid chromatography-tandem mass spectrometry
by: Nudrat Aziz, et al.
Published: (2021-01-01)

Prenatal Diagnosis of Different Polymorphisms of β-globin Gene in Ahvaz
by: Ali Dehghanifard, et al.
Published: (2013-06-01)

Prenatal Diagnosis of different Polymorphisms of β-globin Gene in Ahvaz
by: Ali Dehghanifard, et al.
Published: (2013-04-01)

Molecular understanding of unusual HbE-β+-thalassemia with Hb phenotype similar to HbE heterozygote: simple and rapid differentiation using HbE levels
by: Wittaya Jomoui, et al.
Published: (2023-12-01)

Molecular basis of a high Hb A2/Hb Fβ-thalassemia trait: a retrospective analysis, genotype-phenotype interaction, diagnostic implication, and identification of a novel interaction with α-globin gene triplication
by: Chayada Soontornpanawet, et al.
Published: (2023-05-01)

Polymorphisms at rs368698783 and rs7482144 loci in the promoter region of the HBG gene are associated with HbF expression
by: DENG Ling, LONG Lan, YANG Yang, JIN Chanchan, LI Suyun, FENG Na, HE Jing
Published: (2023-02-01)

LSD1 inhibition enhances robust fetal hemoglobin induction in human β0-thalassemia/HbE erythroid cells
by: Orapan Sripichai, et al.
Published: (2021-11-01)

Review of clinical and hematological profile of hemoglobin D cases in a single centre
by: Neha Singh, et al.
Published: (2023-01-01)

Impaired Terminal Erythroid Maturation in β<sup>0</sup>-Thalassemia/HbE Patients with Different Clinical Severity
by: Thunwarat Suriyun, et al.
Published: (2022-03-01)

Determining the current prevalence of β-thalassemia variants in Jordan
by: Diya Hasan, et al.
Published: (2023-03-01)