Serum 25-hydroxy vitamin D: A possible role in acne vulgaris
Background: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous apparatus. Vitamin D controls the immune system and the proliferation and differentiation of sebocytes and keratinocytes. In addition, it has antioxidant and anti-comedogenic properties. In vitro studies showed tha...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Clinical Dermatology Review |
| Subjects: | |
| Online Access: | http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2022;volume=6;issue=1;spage=22;epage=27;aulast=Sharaf |
| _version_ | 1818489529879756800 |
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| author | Elshahat A Sharaf Hamdy F Marzouk Walaa M Abdelmageed Mohammad A Gaballah |
| author_facet | Elshahat A Sharaf Hamdy F Marzouk Walaa M Abdelmageed Mohammad A Gaballah |
| author_sort | Elshahat A Sharaf |
| collection | DOAJ |
| description | Background: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous apparatus. Vitamin D controls the immune system and the proliferation and differentiation of sebocytes and keratinocytes. In addition, it has antioxidant and anti-comedogenic properties. In vitro studies showed that Vitamin D had a functional part in the acne development. Serum Vitamin D levels were previously estimated in AV patients with conflicting results. Objective: To compare 25-hydroxyvitamin D (25[OH] D) serum level in AV patients with healthy controls and to assess the association between 25(OH) D and disease severity to detect any possible role of Vitamin D in AV pathogenesis and treatment. Materials and Methods: 25 (OH) D levels were estimated in 80 AV patients and 40 age- and sex-matched controls using the enzyme-linked immunosorbemt assay technique. Results: 25(OH) D serum levels were significantly lower in patients as compared to controls. Although of no statistical significances, serum 25(OH) D levels were lower in severe and very severe cases than mild and moderate cases. There was significant negative correlation between serum 25(OH) D level and age of onset of AV. However, there were nonsignificant correlations between 25(OH) D blood levels and other patients' characters such as age, sex, occupation, duration of the disease, family history of AV, body mass index, and sites of the lesions. Conclusions: Vitamin D may have a role in the pathogenesis of in AV patients. Further studies on a larger number of patients are recommended to confirm the validity of our results and to evaluate the therapeutic role of Vitamin D supplementation or topical vitamin analogs in acne treatment. |
| first_indexed | 2024-12-10T17:05:10Z |
| format | Article |
| id | doaj.art-8e6a81f4bcc24ae080912552c6ce4dee |
| institution | Directory Open Access Journal |
| issn | 2542-551X 2542-5528 |
| language | English |
| last_indexed | 2024-12-10T17:05:10Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Clinical Dermatology Review |
| spelling | doaj.art-8e6a81f4bcc24ae080912552c6ce4dee2022-12-22T01:40:29ZengWolters Kluwer Medknow PublicationsClinical Dermatology Review2542-551X2542-55282022-01-0161222710.4103/cdr.cdr_3_21Serum 25-hydroxy vitamin D: A possible role in acne vulgarisElshahat A SharafHamdy F MarzoukWalaa M AbdelmageedMohammad A GaballahBackground: Acne vulgaris (AV) is a chronic inflammatory disease of the pilosebaceous apparatus. Vitamin D controls the immune system and the proliferation and differentiation of sebocytes and keratinocytes. In addition, it has antioxidant and anti-comedogenic properties. In vitro studies showed that Vitamin D had a functional part in the acne development. Serum Vitamin D levels were previously estimated in AV patients with conflicting results. Objective: To compare 25-hydroxyvitamin D (25[OH] D) serum level in AV patients with healthy controls and to assess the association between 25(OH) D and disease severity to detect any possible role of Vitamin D in AV pathogenesis and treatment. Materials and Methods: 25 (OH) D levels were estimated in 80 AV patients and 40 age- and sex-matched controls using the enzyme-linked immunosorbemt assay technique. Results: 25(OH) D serum levels were significantly lower in patients as compared to controls. Although of no statistical significances, serum 25(OH) D levels were lower in severe and very severe cases than mild and moderate cases. There was significant negative correlation between serum 25(OH) D level and age of onset of AV. However, there were nonsignificant correlations between 25(OH) D blood levels and other patients' characters such as age, sex, occupation, duration of the disease, family history of AV, body mass index, and sites of the lesions. Conclusions: Vitamin D may have a role in the pathogenesis of in AV patients. Further studies on a larger number of patients are recommended to confirm the validity of our results and to evaluate the therapeutic role of Vitamin D supplementation or topical vitamin analogs in acne treatment.http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2022;volume=6;issue=1;spage=22;epage=27;aulast=Sharaf25-hydroxyacnevitamin dvulgaris |
| spellingShingle | Elshahat A Sharaf Hamdy F Marzouk Walaa M Abdelmageed Mohammad A Gaballah Serum 25-hydroxy vitamin D: A possible role in acne vulgaris Clinical Dermatology Review 25-hydroxy acne vitamin d vulgaris |
| title | Serum 25-hydroxy vitamin D: A possible role in acne vulgaris |
| title_full | Serum 25-hydroxy vitamin D: A possible role in acne vulgaris |
| title_fullStr | Serum 25-hydroxy vitamin D: A possible role in acne vulgaris |
| title_full_unstemmed | Serum 25-hydroxy vitamin D: A possible role in acne vulgaris |
| title_short | Serum 25-hydroxy vitamin D: A possible role in acne vulgaris |
| title_sort | serum 25 hydroxy vitamin d a possible role in acne vulgaris |
| topic | 25-hydroxy acne vitamin d vulgaris |
| url | http://www.cdriadvlkn.org/article.asp?issn=2542-551X;year=2022;volume=6;issue=1;spage=22;epage=27;aulast=Sharaf |
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