Effect of U74006F (Tirilazad Mesylate) in rabbit eyes after argon laser trabeculoplasty
A new free radical scavenger, U74006F (Upjohn Company, Kalamazoo, MI, USA) was studied to determine if it would have a beneficial effect on preventing intraocular pressure (IOP) spikes and reducing blood-aqueous barrier (BAB) breakdown in rabbits after argon laser trabeculoplasty (ALT). The post-ALT...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
1994-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=1994;volume=42;issue=3;spage=149;epage=152;aulast=Fiscella |
| _version_ | 1811318688184270848 |
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| author | Fiscella Richard Asrani S Hillman D Rusin M Le H |
| author_facet | Fiscella Richard Asrani S Hillman D Rusin M Le H |
| author_sort | Fiscella Richard |
| collection | DOAJ |
| description | A new free radical scavenger, U74006F (Upjohn Company, Kalamazoo, MI, USA) was studied to determine if it would have a beneficial effect on preventing intraocular pressure (IOP) spikes and reducing blood-aqueous barrier (BAB) breakdown in rabbits after argon laser trabeculoplasty (ALT). The post-ALT IOP averaged 24.7 mm Hg (+/- 3.8 mm Hg; N = 6) and 30.3 mm Hg (+/- 6.9 mm Hg; N = 7) at 1 hour (p = 0.097) and 22.7 mm Hg (+/- 1.9) and 27.3 mm Hg (+/- 7.0 mm Hg) at 3 hours in the U74006F and vehicle groups (p = 0.137), respectively. By 48 hours, the IOP averaged 12.8 +/- 2.2 mm Hg in the U74006F group and 12.4 +/- 2.4 mm Hg in the vehicle group (P = 0.757). The aqueous fluorescein permeability (AFP) between lasered and unlasered eyes was determined for the U74006F and vehicle-treated groups by aqueous fluorophotometry. Prelaser or baseline AFP was determined for the U74006F (-0.236 +/- 0.236) and vehicle (-0.145 +/- 0.237) groups (p = 0.505). At day 2 posttreatment, the U74006F group and the placebo group both reported similar AFP of 5.109 +/- 4.831 and 5.680 +/- 4.280 (p = 0.827), respectively. At one week post-ALT, AFP for the U74006F group (0.109 +/- 0.367) had returned close to baseline, while that of the vehicle group (0.426 +/- 0.511) was still quite elevated (p = 0.220). U74006F appears to be beneficial in the prevention of acute elevation of IOP following ALT but not in the prevention of Blood-Aqueous Barrier (BAB) breakdown. |
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| format | Article |
| id | doaj.art-8e6f6ef3f9f84dc5ac828c5c0aa2cb1c |
| institution | Directory Open Access Journal |
| issn | 0301-4738 |
| language | English |
| last_indexed | 2024-04-13T12:29:02Z |
| publishDate | 1994-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-8e6f6ef3f9f84dc5ac828c5c0aa2cb1c2022-12-22T02:46:54ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381994-01-01423149152Effect of U74006F (Tirilazad Mesylate) in rabbit eyes after argon laser trabeculoplastyFiscella RichardAsrani SHillman DRusin MLe HA new free radical scavenger, U74006F (Upjohn Company, Kalamazoo, MI, USA) was studied to determine if it would have a beneficial effect on preventing intraocular pressure (IOP) spikes and reducing blood-aqueous barrier (BAB) breakdown in rabbits after argon laser trabeculoplasty (ALT). The post-ALT IOP averaged 24.7 mm Hg (+/- 3.8 mm Hg; N = 6) and 30.3 mm Hg (+/- 6.9 mm Hg; N = 7) at 1 hour (p = 0.097) and 22.7 mm Hg (+/- 1.9) and 27.3 mm Hg (+/- 7.0 mm Hg) at 3 hours in the U74006F and vehicle groups (p = 0.137), respectively. By 48 hours, the IOP averaged 12.8 +/- 2.2 mm Hg in the U74006F group and 12.4 +/- 2.4 mm Hg in the vehicle group (P = 0.757). The aqueous fluorescein permeability (AFP) between lasered and unlasered eyes was determined for the U74006F and vehicle-treated groups by aqueous fluorophotometry. Prelaser or baseline AFP was determined for the U74006F (-0.236 +/- 0.236) and vehicle (-0.145 +/- 0.237) groups (p = 0.505). At day 2 posttreatment, the U74006F group and the placebo group both reported similar AFP of 5.109 +/- 4.831 and 5.680 +/- 4.280 (p = 0.827), respectively. At one week post-ALT, AFP for the U74006F group (0.109 +/- 0.367) had returned close to baseline, while that of the vehicle group (0.426 +/- 0.511) was still quite elevated (p = 0.220). U74006F appears to be beneficial in the prevention of acute elevation of IOP following ALT but not in the prevention of Blood-Aqueous Barrier (BAB) breakdown.http://www.ijo.in/article.asp?issn=0301-4738;year=1994;volume=42;issue=3;spage=149;epage=152;aulast=FiscellaIntraocular pressure- Free radical scavengers - Blood-aqueous barrier--Argon laser trabeculoplasty - U74006F |
| spellingShingle | Fiscella Richard Asrani S Hillman D Rusin M Le H Effect of U74006F (Tirilazad Mesylate) in rabbit eyes after argon laser trabeculoplasty Indian Journal of Ophthalmology Intraocular pressure- Free radical scavengers - Blood-aqueous barrier--Argon laser trabeculoplasty - U74006F |
| title | Effect of U74006F (Tirilazad Mesylate) in rabbit eyes after argon laser trabeculoplasty |
| title_full | Effect of U74006F (Tirilazad Mesylate) in rabbit eyes after argon laser trabeculoplasty |
| title_fullStr | Effect of U74006F (Tirilazad Mesylate) in rabbit eyes after argon laser trabeculoplasty |
| title_full_unstemmed | Effect of U74006F (Tirilazad Mesylate) in rabbit eyes after argon laser trabeculoplasty |
| title_short | Effect of U74006F (Tirilazad Mesylate) in rabbit eyes after argon laser trabeculoplasty |
| title_sort | effect of u74006f tirilazad mesylate in rabbit eyes after argon laser trabeculoplasty |
| topic | Intraocular pressure- Free radical scavengers - Blood-aqueous barrier--Argon laser trabeculoplasty - U74006F |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=1994;volume=42;issue=3;spage=149;epage=152;aulast=Fiscella |
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