Survival benefit of active surveillance for papillary thyroid carcinoma: a propensity score matching analysis based on SEER database
BackgroundOver-treatment of papillary thyroid microcarcinoma (PTMC) has become a common issue. Although active surveillance (AS) has been proposed as an alternative treatment to immediate surgery for PTMC, its inclusion criteria and mortality risk have not been clearly defined. The purpose of this s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1185650/full |
| _version_ | 1797808272213803008 |
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| author | Jinzhe Bi Peng-fei Lyu Yu Wang Hao Zhang |
| author_facet | Jinzhe Bi Peng-fei Lyu Yu Wang Hao Zhang |
| author_sort | Jinzhe Bi |
| collection | DOAJ |
| description | BackgroundOver-treatment of papillary thyroid microcarcinoma (PTMC) has become a common issue. Although active surveillance (AS) has been proposed as an alternative treatment to immediate surgery for PTMC, its inclusion criteria and mortality risk have not been clearly defined. The purpose of this study was to investigate whether surgery can achieve significant survival benefits in patients with larger tumor diameter of papillary thyroid carcinoma (PTC), in order to evaluate the feasibility of expanding the threshold for active surveillance.MethodsThis study retrospectively collected data of patients with papillary thyroid carcinoma from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2019. The propensity score matching (PSM) method was used to minimize confounding factors and selection bias between the surgery and non-surgery groups, and to compare the clinical and pathological characteristics between the two groups based on the SEER cohort. Meanwhile, the impact of surgery on prognosis was compared using Kaplan-Meier estimates and Cox proportional hazard models.ResultsA total of 175,195 patients were extracted from the database, including 686 patients who received non-surgical treatment, and were matched 1:1 with patients who received surgical treatment using propensity score matching. The Cox proportional hazard forest plot showed that age was the most important factor affecting overall survival (OS) of patients, while tumor size was the most important factor affecting disease-specific survival (DSS) of patients. In terms of tumor size, there was no significant difference in DSS between PTC patients with tumor size of 0-1.0cm who underwent surgical treatment and those who underwent non-surgical treatment, and the relative survival risk began to increase after the tumor size exceeded 2.0cm. Additionally, the Cox proportional hazard forest plot showed that chemotherapy, radioactive iodine, and multifocality were negative factors affecting DSS. Moreover, the risk of death increased over time, and no plateau phase was observed.ConclusionFor patients with papillary thyroid carcinoma (PTC) staged as T1N0M0, AS is a feasible management strategy. As the tumor diameter increases, the risk of death without surgical treatment gradually increases, but there may be a threshold. Within this range, a non-surgical approach may be a potentially viable management strategy. However, beyond this range, surgery may be more beneficial for patient survival. Therefore, it is necessary to conduct more large-scale prospective randomized controlled trials to further confirm these findings. |
| first_indexed | 2024-03-13T06:35:14Z |
| format | Article |
| id | doaj.art-8e709d5e48404298b82a2310cd3a03de |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T06:35:14Z |
| publishDate | 2023-06-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-8e709d5e48404298b82a2310cd3a03de2023-06-09T05:17:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.11856501185650Survival benefit of active surveillance for papillary thyroid carcinoma: a propensity score matching analysis based on SEER databaseJinzhe Bi0Peng-fei Lyu1Yu Wang2Hao Zhang3Department of General Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, ChinaDepartment of General Surgery, The First Affiliated Hospital of Hainan Medical University, Haikou, ChinaBackgroundOver-treatment of papillary thyroid microcarcinoma (PTMC) has become a common issue. Although active surveillance (AS) has been proposed as an alternative treatment to immediate surgery for PTMC, its inclusion criteria and mortality risk have not been clearly defined. The purpose of this study was to investigate whether surgery can achieve significant survival benefits in patients with larger tumor diameter of papillary thyroid carcinoma (PTC), in order to evaluate the feasibility of expanding the threshold for active surveillance.MethodsThis study retrospectively collected data of patients with papillary thyroid carcinoma from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2019. The propensity score matching (PSM) method was used to minimize confounding factors and selection bias between the surgery and non-surgery groups, and to compare the clinical and pathological characteristics between the two groups based on the SEER cohort. Meanwhile, the impact of surgery on prognosis was compared using Kaplan-Meier estimates and Cox proportional hazard models.ResultsA total of 175,195 patients were extracted from the database, including 686 patients who received non-surgical treatment, and were matched 1:1 with patients who received surgical treatment using propensity score matching. The Cox proportional hazard forest plot showed that age was the most important factor affecting overall survival (OS) of patients, while tumor size was the most important factor affecting disease-specific survival (DSS) of patients. In terms of tumor size, there was no significant difference in DSS between PTC patients with tumor size of 0-1.0cm who underwent surgical treatment and those who underwent non-surgical treatment, and the relative survival risk began to increase after the tumor size exceeded 2.0cm. Additionally, the Cox proportional hazard forest plot showed that chemotherapy, radioactive iodine, and multifocality were negative factors affecting DSS. Moreover, the risk of death increased over time, and no plateau phase was observed.ConclusionFor patients with papillary thyroid carcinoma (PTC) staged as T1N0M0, AS is a feasible management strategy. As the tumor diameter increases, the risk of death without surgical treatment gradually increases, but there may be a threshold. Within this range, a non-surgical approach may be a potentially viable management strategy. However, beyond this range, surgery may be more beneficial for patient survival. Therefore, it is necessary to conduct more large-scale prospective randomized controlled trials to further confirm these findings.https://www.frontiersin.org/articles/10.3389/fonc.2023.1185650/fullpapillary thyroid microcarcinoma (PTMC)active surveillance (AS)papillary thyroid carcinoma (PTC)propensity score matching (PSM)SEER (Surveillance Epidemiology and End Results) database |
| spellingShingle | Jinzhe Bi Peng-fei Lyu Yu Wang Hao Zhang Survival benefit of active surveillance for papillary thyroid carcinoma: a propensity score matching analysis based on SEER database Frontiers in Oncology papillary thyroid microcarcinoma (PTMC) active surveillance (AS) papillary thyroid carcinoma (PTC) propensity score matching (PSM) SEER (Surveillance Epidemiology and End Results) database |
| title | Survival benefit of active surveillance for papillary thyroid carcinoma: a propensity score matching analysis based on SEER database |
| title_full | Survival benefit of active surveillance for papillary thyroid carcinoma: a propensity score matching analysis based on SEER database |
| title_fullStr | Survival benefit of active surveillance for papillary thyroid carcinoma: a propensity score matching analysis based on SEER database |
| title_full_unstemmed | Survival benefit of active surveillance for papillary thyroid carcinoma: a propensity score matching analysis based on SEER database |
| title_short | Survival benefit of active surveillance for papillary thyroid carcinoma: a propensity score matching analysis based on SEER database |
| title_sort | survival benefit of active surveillance for papillary thyroid carcinoma a propensity score matching analysis based on seer database |
| topic | papillary thyroid microcarcinoma (PTMC) active surveillance (AS) papillary thyroid carcinoma (PTC) propensity score matching (PSM) SEER (Surveillance Epidemiology and End Results) database |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1185650/full |
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