Protective Effects of Moschus Against Carbon Tetrachloride-Induced Acute Hepatotoxicity in ICR Mice
Objectives : This study was aimed at investigating liver protection mechanism of Moschus by inducing liver toxicity through CCl4 in mice and evaluated histological and serological findings. Methods : Experiment groups was categorized into untreated normal group, CCl4 treated control group, and oral...
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| Format: | Article |
| Language: | English |
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Korean Pharmacopuncture Institute
2006-02-01
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| Series: | Journal of Pharmacopuncture |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3831/KPI.2006.9.1.045 |
| _version_ | 1811270807245029376 |
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| author | Jae Seuk Park Seung-wook Kim Ki Rok Kwon Kyu Jae Lee |
| author_facet | Jae Seuk Park Seung-wook Kim Ki Rok Kwon Kyu Jae Lee |
| author_sort | Jae Seuk Park |
| collection | DOAJ |
| description | Objectives : This study was aimed at investigating liver protection mechanism of Moschus by inducing liver toxicity through CCl4 in mice and evaluated histological and serological findings.
Methods : Experiment groups was categorized into untreated normal group, CCl4 treated control group, and orally administered Moschus experiment group. At the termination of experiment, gross examination of the liver as well as histological findings, and Total protein, Total bilirubin, Direct bilirubin SGOT, SGPT, and ALP contents in the serum were evaluated.
Results : 1. For gross examination and histological findings, CCl4 treated control group showed destroyed lobular structure, increased fibrosis, as well as hepatic cirrhosis. For the group treated with Moschus, the lobular structure suffered less damage, and showed lower level of fibrosis and liver cirrhosis compared to the control group.
2. For serum analysis, Total protein were significantly increased in the Moschus experiment group than the control group.
3. Total bilirubin didn't show significant differences between the two groups. but direct bilirubin was significantly increased in the Moschus experiment group than the control group.
4. SGOT, SGPT, were significantly decreased in the normal and Moschus experiment groups compared to the control group.
5. ALP was significantly decreased in the normal group compared to the control group, but Moschus experiment group didn't show significant differences compared to the control group.
Conclusion : Taken together, Moschus can be effectively used for recovering the liver functions and further researches must be conducted to verify the efficacies of Moschus bile juice. |
| first_indexed | 2024-04-12T22:08:44Z |
| format | Article |
| id | doaj.art-8e7100a324874096ae1aef990bb776a5 |
| institution | Directory Open Access Journal |
| issn | 2093-6966 2234-6856 |
| language | English |
| last_indexed | 2024-04-12T22:08:44Z |
| publishDate | 2006-02-01 |
| publisher | Korean Pharmacopuncture Institute |
| record_format | Article |
| series | Journal of Pharmacopuncture |
| spelling | doaj.art-8e7100a324874096ae1aef990bb776a52022-12-22T03:14:50ZengKorean Pharmacopuncture InstituteJournal of Pharmacopuncture2093-69662234-68562006-02-0191455210.3831/KPI.2006.9.1.045Protective Effects of Moschus Against Carbon Tetrachloride-Induced Acute Hepatotoxicity in ICR MiceJae Seuk Park0Seung-wook Kim1Ki Rok Kwon2Kyu Jae Lee3Department of Acupuncture & Moxibustion, Oriental Medical College, Sangji UniversityDepartment of Oriental medical college, Sangji UniversityDepartment of Acupuncture & Moxibustion, Oriental Medical College, Sangji UniversityDepartment of Paracytology & Institute of Basic Medical Science, Wonju Medical College, YonSei UniversityObjectives : This study was aimed at investigating liver protection mechanism of Moschus by inducing liver toxicity through CCl4 in mice and evaluated histological and serological findings. Methods : Experiment groups was categorized into untreated normal group, CCl4 treated control group, and orally administered Moschus experiment group. At the termination of experiment, gross examination of the liver as well as histological findings, and Total protein, Total bilirubin, Direct bilirubin SGOT, SGPT, and ALP contents in the serum were evaluated. Results : 1. For gross examination and histological findings, CCl4 treated control group showed destroyed lobular structure, increased fibrosis, as well as hepatic cirrhosis. For the group treated with Moschus, the lobular structure suffered less damage, and showed lower level of fibrosis and liver cirrhosis compared to the control group. 2. For serum analysis, Total protein were significantly increased in the Moschus experiment group than the control group. 3. Total bilirubin didn't show significant differences between the two groups. but direct bilirubin was significantly increased in the Moschus experiment group than the control group. 4. SGOT, SGPT, were significantly decreased in the normal and Moschus experiment groups compared to the control group. 5. ALP was significantly decreased in the normal group compared to the control group, but Moschus experiment group didn't show significant differences compared to the control group. Conclusion : Taken together, Moschus can be effectively used for recovering the liver functions and further researches must be conducted to verify the efficacies of Moschus bile juice.http://dx.doi.org/10.3831/KPI.2006.9.1.045MoschusCCl4hepatotoxicity |
| spellingShingle | Jae Seuk Park Seung-wook Kim Ki Rok Kwon Kyu Jae Lee Protective Effects of Moschus Against Carbon Tetrachloride-Induced Acute Hepatotoxicity in ICR Mice Journal of Pharmacopuncture Moschus CCl4 hepatotoxicity |
| title | Protective Effects of Moschus Against Carbon Tetrachloride-Induced Acute Hepatotoxicity in ICR Mice |
| title_full | Protective Effects of Moschus Against Carbon Tetrachloride-Induced Acute Hepatotoxicity in ICR Mice |
| title_fullStr | Protective Effects of Moschus Against Carbon Tetrachloride-Induced Acute Hepatotoxicity in ICR Mice |
| title_full_unstemmed | Protective Effects of Moschus Against Carbon Tetrachloride-Induced Acute Hepatotoxicity in ICR Mice |
| title_short | Protective Effects of Moschus Against Carbon Tetrachloride-Induced Acute Hepatotoxicity in ICR Mice |
| title_sort | protective effects of moschus against carbon tetrachloride induced acute hepatotoxicity in icr mice |
| topic | Moschus CCl4 hepatotoxicity |
| url | http://dx.doi.org/10.3831/KPI.2006.9.1.045 |
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