Case report: Going through pregnancy safely after twice partial nephrectomy for bilateral kidneys with HLRCC-associated RCC
BackgroundHLRCC-associated RCC (hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinoma) caused by germline mutations of the fumarate hydratase (FH) gene is a rare autosomal dominant genetic renal cancer. At present, there are no reports of bilateral kidneys with HLRCC-associ...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.932996/full |
| _version_ | 1811251419548745728 |
|---|---|
| author | Kunhan Dai Wencheng Jiang Siyu Chen Shengjun Luo Siwei Ding Delin Wang |
| author_facet | Kunhan Dai Wencheng Jiang Siyu Chen Shengjun Luo Siwei Ding Delin Wang |
| author_sort | Kunhan Dai |
| collection | DOAJ |
| description | BackgroundHLRCC-associated RCC (hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinoma) caused by germline mutations of the fumarate hydratase (FH) gene is a rare autosomal dominant genetic renal cancer. At present, there are no reports of bilateral kidneys with HLRCC-associated RCC, let alone safe pregnancy after twice partial nephrectomy for bilateral kidney HLRCC-associated RCC.Case presentationWe report a 25-year-old woman with bilateral renal tumors detected by ultrasound screening during a routine checkup. CT revealed a soft tissue mass in the parenchyma of the left kidney and a nodular soft tissue mass in the lower pole of the right kidney. She underwent robot-assisted laparoscopic left partial nephrectomy and underwent laparoscopic right partial nephrectomy 3 months after the first surgery. Heterozygous mutation in the FH gene on the patient’s tumor tissue was detected by genetic testing. Combined with the patient’s medical history, microstructure and immunohistochemical staining of tumor tissue, and genetic test results, the pathological reports after two operations concluded HLRCC-associated RCC. Then, she was injected with interferon and nivolumab as a preventative treatment against tumor recurrence. Up to 38 months after surgery, having given birth to a baby, till now there was no tumor progression.ConclusionsThis is a clinically significant case, as it provides a reference for pregnancy in patients undergoing partial nephrectomy for bilateral kidneys with HLRCC-associated RCC and may indicate an effective approach to preventing tumor recurrence by nivolumab in patients with HLRCC-associated RCC. |
| first_indexed | 2024-04-12T16:20:07Z |
| format | Article |
| id | doaj.art-8e722c7e1fac4d2d9fdafbe62dc3acd0 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T16:20:07Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8e722c7e1fac4d2d9fdafbe62dc3acd02022-12-22T03:25:36ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-10-011210.3389/fonc.2022.932996932996Case report: Going through pregnancy safely after twice partial nephrectomy for bilateral kidneys with HLRCC-associated RCCKunhan DaiWencheng JiangSiyu ChenShengjun LuoSiwei DingDelin WangBackgroundHLRCC-associated RCC (hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinoma) caused by germline mutations of the fumarate hydratase (FH) gene is a rare autosomal dominant genetic renal cancer. At present, there are no reports of bilateral kidneys with HLRCC-associated RCC, let alone safe pregnancy after twice partial nephrectomy for bilateral kidney HLRCC-associated RCC.Case presentationWe report a 25-year-old woman with bilateral renal tumors detected by ultrasound screening during a routine checkup. CT revealed a soft tissue mass in the parenchyma of the left kidney and a nodular soft tissue mass in the lower pole of the right kidney. She underwent robot-assisted laparoscopic left partial nephrectomy and underwent laparoscopic right partial nephrectomy 3 months after the first surgery. Heterozygous mutation in the FH gene on the patient’s tumor tissue was detected by genetic testing. Combined with the patient’s medical history, microstructure and immunohistochemical staining of tumor tissue, and genetic test results, the pathological reports after two operations concluded HLRCC-associated RCC. Then, she was injected with interferon and nivolumab as a preventative treatment against tumor recurrence. Up to 38 months after surgery, having given birth to a baby, till now there was no tumor progression.ConclusionsThis is a clinically significant case, as it provides a reference for pregnancy in patients undergoing partial nephrectomy for bilateral kidneys with HLRCC-associated RCC and may indicate an effective approach to preventing tumor recurrence by nivolumab in patients with HLRCC-associated RCC.https://www.frontiersin.org/articles/10.3389/fonc.2022.932996/fullpregnancyhereditary carcinomarenal cell carcinomapartial nephrectomyFH |
| spellingShingle | Kunhan Dai Wencheng Jiang Siyu Chen Shengjun Luo Siwei Ding Delin Wang Case report: Going through pregnancy safely after twice partial nephrectomy for bilateral kidneys with HLRCC-associated RCC Frontiers in Oncology pregnancy hereditary carcinoma renal cell carcinoma partial nephrectomy FH |
| title | Case report: Going through pregnancy safely after twice partial nephrectomy for bilateral kidneys with HLRCC-associated RCC |
| title_full | Case report: Going through pregnancy safely after twice partial nephrectomy for bilateral kidneys with HLRCC-associated RCC |
| title_fullStr | Case report: Going through pregnancy safely after twice partial nephrectomy for bilateral kidneys with HLRCC-associated RCC |
| title_full_unstemmed | Case report: Going through pregnancy safely after twice partial nephrectomy for bilateral kidneys with HLRCC-associated RCC |
| title_short | Case report: Going through pregnancy safely after twice partial nephrectomy for bilateral kidneys with HLRCC-associated RCC |
| title_sort | case report going through pregnancy safely after twice partial nephrectomy for bilateral kidneys with hlrcc associated rcc |
| topic | pregnancy hereditary carcinoma renal cell carcinoma partial nephrectomy FH |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.932996/full |
| work_keys_str_mv | AT kunhandai casereportgoingthroughpregnancysafelyaftertwicepartialnephrectomyforbilateralkidneyswithhlrccassociatedrcc AT wenchengjiang casereportgoingthroughpregnancysafelyaftertwicepartialnephrectomyforbilateralkidneyswithhlrccassociatedrcc AT siyuchen casereportgoingthroughpregnancysafelyaftertwicepartialnephrectomyforbilateralkidneyswithhlrccassociatedrcc AT shengjunluo casereportgoingthroughpregnancysafelyaftertwicepartialnephrectomyforbilateralkidneyswithhlrccassociatedrcc AT siweiding casereportgoingthroughpregnancysafelyaftertwicepartialnephrectomyforbilateralkidneyswithhlrccassociatedrcc AT delinwang casereportgoingthroughpregnancysafelyaftertwicepartialnephrectomyforbilateralkidneyswithhlrccassociatedrcc |