MicroRNAs in Cardiac Diseases
Since their discovery 20 years ago, microRNAs have been related to posttranscriptional regulation of gene expression in major cardiac physiological and pathological processes. We know now that cardiac muscle phenotypes are tightly regulated by multiple noncoding RNA species to maintain cardiac homeo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/7/737 |
| _version_ | 1797715386812071936 |
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| author | Robin M.W. Colpaert Martina Calore |
| author_facet | Robin M.W. Colpaert Martina Calore |
| author_sort | Robin M.W. Colpaert |
| collection | DOAJ |
| description | Since their discovery 20 years ago, microRNAs have been related to posttranscriptional regulation of gene expression in major cardiac physiological and pathological processes. We know now that cardiac muscle phenotypes are tightly regulated by multiple noncoding RNA species to maintain cardiac homeostasis. Upon stress or various pathological conditions, this class of non-coding RNAs has been found to modulate different cardiac pathological conditions, such as contractility, arrhythmia, myocardial infarction, hypertrophy, and inherited cardiomyopathies. This review summarizes and updates microRNAs playing a role in the different processes underlying the pathogenic phenotypes of cardiac muscle and highlights their potential role as disease biomarkers and therapeutic targets. |
| first_indexed | 2024-03-12T08:06:01Z |
| format | Article |
| id | doaj.art-8e73dcd833164d24a62cd4db5343c5f0 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:06:01Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8e73dcd833164d24a62cd4db5343c5f02023-09-02T19:30:44ZengMDPI AGCells2073-44092019-07-018773710.3390/cells8070737cells8070737MicroRNAs in Cardiac DiseasesRobin M.W. Colpaert0Martina Calore1IMAiA-Institute for Molecular Biology and RNA Technology, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The NetherlandsIMAiA-Institute for Molecular Biology and RNA Technology, Faculty of Science and Engineering, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER Maastricht, The NetherlandsSince their discovery 20 years ago, microRNAs have been related to posttranscriptional regulation of gene expression in major cardiac physiological and pathological processes. We know now that cardiac muscle phenotypes are tightly regulated by multiple noncoding RNA species to maintain cardiac homeostasis. Upon stress or various pathological conditions, this class of non-coding RNAs has been found to modulate different cardiac pathological conditions, such as contractility, arrhythmia, myocardial infarction, hypertrophy, and inherited cardiomyopathies. This review summarizes and updates microRNAs playing a role in the different processes underlying the pathogenic phenotypes of cardiac muscle and highlights their potential role as disease biomarkers and therapeutic targets.https://www.mdpi.com/2073-4409/8/7/737heartmiRNAcardiac diseasesinherited cardiomyopathies |
| spellingShingle | Robin M.W. Colpaert Martina Calore MicroRNAs in Cardiac Diseases Cells heart miRNA cardiac diseases inherited cardiomyopathies |
| title | MicroRNAs in Cardiac Diseases |
| title_full | MicroRNAs in Cardiac Diseases |
| title_fullStr | MicroRNAs in Cardiac Diseases |
| title_full_unstemmed | MicroRNAs in Cardiac Diseases |
| title_short | MicroRNAs in Cardiac Diseases |
| title_sort | micrornas in cardiac diseases |
| topic | heart miRNA cardiac diseases inherited cardiomyopathies |
| url | https://www.mdpi.com/2073-4409/8/7/737 |
| work_keys_str_mv | AT robinmwcolpaert micrornasincardiacdiseases AT martinacalore micrornasincardiacdiseases |