Quantitative analysis of macular microcirculation changes in diabetic retinopathy patients by optical coherence tomography angiography
AIM: To evaluate the macular microcirculation changes in patients with diabetic retinopathy(DR)by optical coherence tomography angiography(OCTA), and correlate the risk factors that may affect the macular microcirculation, so as to provide a clinical basis for early screening, diagnosis and therapeu...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2023-06-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2023/6/202306030.pdf |
| _version_ | 1797816810076110848 |
|---|---|
| author | Xin Lu Xing-Xing Zhao En-Hui Yi Yi-Ping Zhang Lu Yu Xiao-Kang He Ye Zhang Zhao-Jiang Du |
| author_facet | Xin Lu Xing-Xing Zhao En-Hui Yi Yi-Ping Zhang Lu Yu Xiao-Kang He Ye Zhang Zhao-Jiang Du |
| author_sort | Xin Lu |
| collection | DOAJ |
| description | AIM: To evaluate the macular microcirculation changes in patients with diabetic retinopathy(DR)by optical coherence tomography angiography(OCTA), and correlate the risk factors that may affect the macular microcirculation, so as to provide a clinical basis for early screening, diagnosis and therapeutic intervention for DR.METHODS: Retrospective study. A total of 75 patients(75 eyes)with type 2 diabetes mellitus(DM)who came to the ophthalmology outpatient clinic and ward of Xi'an Central Hospital from May to October 2022 were collected, and the DM patients were further divided into non-DR(NDR)group, non-proliferative DR(NPDR)group and proliferative DR(PDR)group, with 28 eyes, 25 eyes and 22 eyes in each group respectively. OCTA was applied to perform a 3mm×3mm blood flow imaging scan of the macular retina to automatically obtain the vascular density(VD)of the superficial retinal macular foveal, the parafoveal(1～3mm), as well as the macular 3mm×3mm and the area of macular foveal avascular zone(FAZ). Furthermore, the alteration of these parameters in patients with different degrees of DR was analyzed.RESULTS: Compared with the NDR group, the VD of the 3mm×3mm superficial retinal capillary(SCP)in the macular region was decreased in both PDR and NPDR group(all P<0.017), and the VD of the parafoveal was decreased in each quadrant(P<0.017), with the most significant decrease in the PDR group. The FAZ area of patients in the PDR and NPDR groups was significantly larger than that in the NDR group(P<0.017). Age, homocysteine, best corrected visual acuity(LogMAR), axial length and glycosylated hemoglobin(HbA1c)of patients with DR were negatively correlated with VD in the macular foveal(P<0.05), while homocysteine, best corrected visual acuity(LogMAR), axial length, and the duration of diabetes were negatively correlated with VD in the macular 3mm×3mm(P<0.05). Triglycerides, best corrected visual acuity(LogMAR), and HbA1c were negatively correlated with VD in the parafoveal(P<0.05), while total cholesterol and central macular thickness had no significant correlation with VD(P>0.05).CONCLUSION: The microcirculation changes in the macular area of DR patients can be monitored by OCTA, and the systemic condition of DR patients is closely related to their macular microcirculation. |
| first_indexed | 2024-03-13T08:43:14Z |
| format | Article |
| id | doaj.art-8e75fe512fac498eb66ff670202e0e86 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-03-13T08:43:14Z |
| publishDate | 2023-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-8e75fe512fac498eb66ff670202e0e862023-05-30T07:55:53ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-06-012361033103910.3980/j.issn.1672-5123.2023.6.30202306030Quantitative analysis of macular microcirculation changes in diabetic retinopathy patients by optical coherence tomography angiographyXin Lu0Xing-Xing Zhao1En-Hui Yi2Yi-Ping Zhang3Lu Yu4Xiao-Kang He5Ye Zhang6Zhao-Jiang Du7Department of Ophthalmology, Xi'an Central Hospital, Xi'an 710005, Shaanxi Province, China; Yan'an University, Yan'an 716000, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an Central Hospital, Xi'an 710005, Shaanxi Province, China; Yan'an University, Yan'an 716000, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an Central Hospital, Xi'an 710005, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an Central Hospital, Xi'an 710005, Shaanxi Province, China; Yan'an University, Yan'an 716000, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an Central Hospital, Xi'an 710005, Shaanxi Province, China; Yan'an University, Yan'an 716000, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an Central Hospital, Xi'an 710005, Shaanxi Province, China; Yan'an University, Yan'an 716000, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an Central Hospital, Xi'an 710005, Shaanxi Province, China; Yan'an University, Yan'an 716000, Shaanxi Province, ChinaDepartment of Ophthalmology, Xi'an Central Hospital, Xi'an 710005, Shaanxi Province, China; Yan'an University, Yan'an 716000, Shaanxi Province, ChinaAIM: To evaluate the macular microcirculation changes in patients with diabetic retinopathy(DR)by optical coherence tomography angiography(OCTA), and correlate the risk factors that may affect the macular microcirculation, so as to provide a clinical basis for early screening, diagnosis and therapeutic intervention for DR.METHODS: Retrospective study. A total of 75 patients(75 eyes)with type 2 diabetes mellitus(DM)who came to the ophthalmology outpatient clinic and ward of Xi'an Central Hospital from May to October 2022 were collected, and the DM patients were further divided into non-DR(NDR)group, non-proliferative DR(NPDR)group and proliferative DR(PDR)group, with 28 eyes, 25 eyes and 22 eyes in each group respectively. OCTA was applied to perform a 3mm×3mm blood flow imaging scan of the macular retina to automatically obtain the vascular density(VD)of the superficial retinal macular foveal, the parafoveal(1～3mm), as well as the macular 3mm×3mm and the area of macular foveal avascular zone(FAZ). Furthermore, the alteration of these parameters in patients with different degrees of DR was analyzed.RESULTS: Compared with the NDR group, the VD of the 3mm×3mm superficial retinal capillary(SCP)in the macular region was decreased in both PDR and NPDR group(all P<0.017), and the VD of the parafoveal was decreased in each quadrant(P<0.017), with the most significant decrease in the PDR group. The FAZ area of patients in the PDR and NPDR groups was significantly larger than that in the NDR group(P<0.017). Age, homocysteine, best corrected visual acuity(LogMAR), axial length and glycosylated hemoglobin(HbA1c)of patients with DR were negatively correlated with VD in the macular foveal(P<0.05), while homocysteine, best corrected visual acuity(LogMAR), axial length, and the duration of diabetes were negatively correlated with VD in the macular 3mm×3mm(P<0.05). Triglycerides, best corrected visual acuity(LogMAR), and HbA1c were negatively correlated with VD in the parafoveal(P<0.05), while total cholesterol and central macular thickness had no significant correlation with VD(P>0.05).CONCLUSION: The microcirculation changes in the macular area of DR patients can be monitored by OCTA, and the systemic condition of DR patients is closely related to their macular microcirculation.http://ies.ijo.cn/cn_publish/2023/6/202306030.pdfdiabetic retinopathyoptical coherence tomography angiographyvascular densitymacular microcirculationfoveal avascular zone |
| spellingShingle | Xin Lu Xing-Xing Zhao En-Hui Yi Yi-Ping Zhang Lu Yu Xiao-Kang He Ye Zhang Zhao-Jiang Du Quantitative analysis of macular microcirculation changes in diabetic retinopathy patients by optical coherence tomography angiography Guoji Yanke Zazhi diabetic retinopathy optical coherence tomography angiography vascular density macular microcirculation foveal avascular zone |
| title | Quantitative analysis of macular microcirculation changes in diabetic retinopathy patients by optical coherence tomography angiography |
| title_full | Quantitative analysis of macular microcirculation changes in diabetic retinopathy patients by optical coherence tomography angiography |
| title_fullStr | Quantitative analysis of macular microcirculation changes in diabetic retinopathy patients by optical coherence tomography angiography |
| title_full_unstemmed | Quantitative analysis of macular microcirculation changes in diabetic retinopathy patients by optical coherence tomography angiography |
| title_short | Quantitative analysis of macular microcirculation changes in diabetic retinopathy patients by optical coherence tomography angiography |
| title_sort | quantitative analysis of macular microcirculation changes in diabetic retinopathy patients by optical coherence tomography angiography |
| topic | diabetic retinopathy optical coherence tomography angiography vascular density macular microcirculation foveal avascular zone |
| url | http://ies.ijo.cn/cn_publish/2023/6/202306030.pdf |
| work_keys_str_mv | AT xinlu quantitativeanalysisofmacularmicrocirculationchangesindiabeticretinopathypatientsbyopticalcoherencetomographyangiography AT xingxingzhao quantitativeanalysisofmacularmicrocirculationchangesindiabeticretinopathypatientsbyopticalcoherencetomographyangiography AT enhuiyi quantitativeanalysisofmacularmicrocirculationchangesindiabeticretinopathypatientsbyopticalcoherencetomographyangiography AT yipingzhang quantitativeanalysisofmacularmicrocirculationchangesindiabeticretinopathypatientsbyopticalcoherencetomographyangiography AT luyu quantitativeanalysisofmacularmicrocirculationchangesindiabeticretinopathypatientsbyopticalcoherencetomographyangiography AT xiaokanghe quantitativeanalysisofmacularmicrocirculationchangesindiabeticretinopathypatientsbyopticalcoherencetomographyangiography AT yezhang quantitativeanalysisofmacularmicrocirculationchangesindiabeticretinopathypatientsbyopticalcoherencetomographyangiography AT zhaojiangdu quantitativeanalysisofmacularmicrocirculationchangesindiabeticretinopathypatientsbyopticalcoherencetomographyangiography |