Effects of inhaled beclomethasone dipropionate/formoterol fumarate/glycopyrronium on diaphragmatic workload and lung function in uncontrolled asthma: a case report
Beclomethasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) single inhaler extrafine triple therapy is effective for the treatment of uncontrolled asthma. Nevertheless, there is a lack of data about the use of diaphragmatic ultrasonography to monitor adult asthmatics while they are rec...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1357362/full |
| _version_ | 1827329817023873024 |
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| author | Antonio Maiorano Chiara Lupia Nicola Montenegro Giuseppe Neri Andrea Bruni Eugenio Garofalo Federico Longhini Claudia Crimi Angelantonio Maglio Alessandro Vatrella Girolamo Pelaia Corrado Pelaia |
| author_facet | Antonio Maiorano Chiara Lupia Nicola Montenegro Giuseppe Neri Andrea Bruni Eugenio Garofalo Federico Longhini Claudia Crimi Angelantonio Maglio Alessandro Vatrella Girolamo Pelaia Corrado Pelaia |
| author_sort | Antonio Maiorano |
| collection | DOAJ |
| description | Beclomethasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) single inhaler extrafine triple therapy is effective for the treatment of uncontrolled asthma. Nevertheless, there is a lack of data about the use of diaphragmatic ultrasonography to monitor adult asthmatics while they are receiving inhaled treatment. We took into consideration a 78-year-old woman complaining of asthma, treated with inhaled corticosteroid/long-acting β2-adrenergic agonist (ICS/LABA), characterized by an asthma control questionnaire-5 (ACQ-5) score and a lung function test suggestive of uncontrolled asthma. Moreover, a diaphragmatic ultrasound showed signs of high diaphragm workload. Because of these findings, we proposed to our patient a shift toward triple inhaled therapy with BDP/FF/G, and she underwent a second evaluation after 7 days of treatment. Improvements in the diaphragmatic ultrasound parameters, lung function test, and ACQ-5 score were found. In particular, we detected a reduction of thickening fraction (TF), and a normalization of the other diaphragmatic measures, indicative of a decrease in diaphragmatic workload. To our knowledge, this is the first literature report showing concomitant improvements of both lung function tests and diaphragmatic ultrasonography parameters, observed in an adult patient with uncontrolled asthma after short-term treatment with the single inhaler triple therapy BDP/FF/G. |
| first_indexed | 2024-03-07T15:47:38Z |
| format | Article |
| id | doaj.art-8e762ecf86df498889073411eb51e0f6 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-07T15:47:38Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-8e762ecf86df498889073411eb51e0f62024-03-05T04:19:33ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-03-011110.3389/fmed.2024.13573621357362Effects of inhaled beclomethasone dipropionate/formoterol fumarate/glycopyrronium on diaphragmatic workload and lung function in uncontrolled asthma: a case reportAntonio Maiorano0Chiara Lupia1Nicola Montenegro2Giuseppe Neri3Andrea Bruni4Eugenio Garofalo5Federico Longhini6Claudia Crimi7Angelantonio Maglio8Alessandro Vatrella9Girolamo Pelaia10Corrado Pelaia11Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, Catania, ItalyDepartment of Medicine, Surgery and Dentistry, University of Salerno, Salerno, ItalyDepartment of Medicine, Surgery and Dentistry, University of Salerno, Salerno, ItalyDepartment of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, ItalyDepartment of Medical and Surgical Sciences, University “Magna Graecia” of Catanzaro, Catanzaro, ItalyBeclomethasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) single inhaler extrafine triple therapy is effective for the treatment of uncontrolled asthma. Nevertheless, there is a lack of data about the use of diaphragmatic ultrasonography to monitor adult asthmatics while they are receiving inhaled treatment. We took into consideration a 78-year-old woman complaining of asthma, treated with inhaled corticosteroid/long-acting β2-adrenergic agonist (ICS/LABA), characterized by an asthma control questionnaire-5 (ACQ-5) score and a lung function test suggestive of uncontrolled asthma. Moreover, a diaphragmatic ultrasound showed signs of high diaphragm workload. Because of these findings, we proposed to our patient a shift toward triple inhaled therapy with BDP/FF/G, and she underwent a second evaluation after 7 days of treatment. Improvements in the diaphragmatic ultrasound parameters, lung function test, and ACQ-5 score were found. In particular, we detected a reduction of thickening fraction (TF), and a normalization of the other diaphragmatic measures, indicative of a decrease in diaphragmatic workload. To our knowledge, this is the first literature report showing concomitant improvements of both lung function tests and diaphragmatic ultrasonography parameters, observed in an adult patient with uncontrolled asthma after short-term treatment with the single inhaler triple therapy BDP/FF/G.https://www.frontiersin.org/articles/10.3389/fmed.2024.1357362/fullasthmatriple inhaled therapydiaphragmatic ultrasoundthickening fractionACQ-5 |
| spellingShingle | Antonio Maiorano Chiara Lupia Nicola Montenegro Giuseppe Neri Andrea Bruni Eugenio Garofalo Federico Longhini Claudia Crimi Angelantonio Maglio Alessandro Vatrella Girolamo Pelaia Corrado Pelaia Effects of inhaled beclomethasone dipropionate/formoterol fumarate/glycopyrronium on diaphragmatic workload and lung function in uncontrolled asthma: a case report Frontiers in Medicine asthma triple inhaled therapy diaphragmatic ultrasound thickening fraction ACQ-5 |
| title | Effects of inhaled beclomethasone dipropionate/formoterol fumarate/glycopyrronium on diaphragmatic workload and lung function in uncontrolled asthma: a case report |
| title_full | Effects of inhaled beclomethasone dipropionate/formoterol fumarate/glycopyrronium on diaphragmatic workload and lung function in uncontrolled asthma: a case report |
| title_fullStr | Effects of inhaled beclomethasone dipropionate/formoterol fumarate/glycopyrronium on diaphragmatic workload and lung function in uncontrolled asthma: a case report |
| title_full_unstemmed | Effects of inhaled beclomethasone dipropionate/formoterol fumarate/glycopyrronium on diaphragmatic workload and lung function in uncontrolled asthma: a case report |
| title_short | Effects of inhaled beclomethasone dipropionate/formoterol fumarate/glycopyrronium on diaphragmatic workload and lung function in uncontrolled asthma: a case report |
| title_sort | effects of inhaled beclomethasone dipropionate formoterol fumarate glycopyrronium on diaphragmatic workload and lung function in uncontrolled asthma a case report |
| topic | asthma triple inhaled therapy diaphragmatic ultrasound thickening fraction ACQ-5 |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1357362/full |
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