Effect of <i>Quamoclit angulata</i> Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic Mice
Type 2 diabetes mellitus (T2DM) is caused by abnormalities of controlling blood glucose and insulin homeostasis. Especially, hyperglycemia causes hyper-inflammation through activation of NLRP3 inflammasome, which can lead to cell apoptosis, hypertrophy, and fibrosis. <i>Quamoclit angulata</...
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MDPI AG
2020-05-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/6/459 |
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| author | Ji Eun Park Heaji Lee Hyunkyung Rho Seong Min Hong Sun Yeou Kim Yunsook Lim |
| author_facet | Ji Eun Park Heaji Lee Hyunkyung Rho Seong Min Hong Sun Yeou Kim Yunsook Lim |
| author_sort | Ji Eun Park |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is caused by abnormalities of controlling blood glucose and insulin homeostasis. Especially, hyperglycemia causes hyper-inflammation through activation of NLRP3 inflammasome, which can lead to cell apoptosis, hypertrophy, and fibrosis. <i>Quamoclit angulata</i> (QA), one of the annual winders, has been shown ameliorative effects on diabetes. The current study investigated whether the QA extract (QAE) attenuated hyperglycemia-induced renal inflammation related to NLRP inflammasome and oxidative stress in high fat diet (HFD)-induced diabetic mice. After T2DM was induced, the mice were treated with QAE (5 or 10 mg/kg/day) by gavage for 12 weeks. The QAE supplementation reduced homeostasis model assessment insulin resistance (HOMA-IR), kidney malfunction, and glomerular hypertrophy in T2DM. Moreover, the QAE treatment significantly attenuated renal NLRP3 inflammasome dependent hyper-inflammation and consequential renal damage caused by oxidative stress, apoptosis, and fibrosis in T2DM. Furthermore, QAE normalized aberrant energy metabolism (downregulation of p-AMPK, sirtuin (SIRT)-1, and PPARγ-coactivator α (PGC-1 α)) in T2DM mice. Taken together, the results suggested that QAE as a natural product has ameliorative effects on renal damage by regulation of oxidative stress and inflammation in T2DM. |
| first_indexed | 2024-03-10T19:32:49Z |
| format | Article |
| id | doaj.art-8e76b9dab1c0460084da70888aee077f |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T19:32:49Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-8e76b9dab1c0460084da70888aee077f2023-11-20T01:57:02ZengMDPI AGAntioxidants2076-39212020-05-019645910.3390/antiox9060459Effect of <i>Quamoclit angulata</i> Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic MiceJi Eun Park0Heaji Lee1Hyunkyung Rho2Seong Min Hong3Sun Yeou Kim4Yunsook Lim5Department of Food and Nutrition, Kyung Hee Univerity, 26 Kyung Hee-Daero, Dongdamun-Gu, Seoul 02447, KoreaDepartment of Food and Nutrition, Kyung Hee Univerity, 26 Kyung Hee-Daero, Dongdamun-Gu, Seoul 02447, KoreaDepartment of Food and Nutrition, Kyung Hee Univerity, 26 Kyung Hee-Daero, Dongdamun-Gu, Seoul 02447, KoreaDepartment of Pharmacognosy, College of Pharmacy, Gachon University, Incheon 21936, KoreaDepartment of Pharmacognosy, College of Pharmacy, Gachon University, Incheon 21936, KoreaDepartment of Food and Nutrition, Kyung Hee Univerity, 26 Kyung Hee-Daero, Dongdamun-Gu, Seoul 02447, KoreaType 2 diabetes mellitus (T2DM) is caused by abnormalities of controlling blood glucose and insulin homeostasis. Especially, hyperglycemia causes hyper-inflammation through activation of NLRP3 inflammasome, which can lead to cell apoptosis, hypertrophy, and fibrosis. <i>Quamoclit angulata</i> (QA), one of the annual winders, has been shown ameliorative effects on diabetes. The current study investigated whether the QA extract (QAE) attenuated hyperglycemia-induced renal inflammation related to NLRP inflammasome and oxidative stress in high fat diet (HFD)-induced diabetic mice. After T2DM was induced, the mice were treated with QAE (5 or 10 mg/kg/day) by gavage for 12 weeks. The QAE supplementation reduced homeostasis model assessment insulin resistance (HOMA-IR), kidney malfunction, and glomerular hypertrophy in T2DM. Moreover, the QAE treatment significantly attenuated renal NLRP3 inflammasome dependent hyper-inflammation and consequential renal damage caused by oxidative stress, apoptosis, and fibrosis in T2DM. Furthermore, QAE normalized aberrant energy metabolism (downregulation of p-AMPK, sirtuin (SIRT)-1, and PPARγ-coactivator α (PGC-1 α)) in T2DM mice. Taken together, the results suggested that QAE as a natural product has ameliorative effects on renal damage by regulation of oxidative stress and inflammation in T2DM.https://www.mdpi.com/2076-3921/9/6/459<i>Quamoclit angulata</i>type 2 diabeteskidney damageinflammationoxidative stressapoptosis |
| spellingShingle | Ji Eun Park Heaji Lee Hyunkyung Rho Seong Min Hong Sun Yeou Kim Yunsook Lim Effect of <i>Quamoclit angulata</i> Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic Mice Antioxidants <i>Quamoclit angulata</i> type 2 diabetes kidney damage inflammation oxidative stress apoptosis |
| title | Effect of <i>Quamoclit angulata</i> Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic Mice |
| title_full | Effect of <i>Quamoclit angulata</i> Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic Mice |
| title_fullStr | Effect of <i>Quamoclit angulata</i> Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic Mice |
| title_full_unstemmed | Effect of <i>Quamoclit angulata</i> Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic Mice |
| title_short | Effect of <i>Quamoclit angulata</i> Extract Supplementation on Oxidative Stress and Inflammation on Hyperglycemia-Induced Renal Damage in Type 2 Diabetic Mice |
| title_sort | effect of i quamoclit angulata i extract supplementation on oxidative stress and inflammation on hyperglycemia induced renal damage in type 2 diabetic mice |
| topic | <i>Quamoclit angulata</i> type 2 diabetes kidney damage inflammation oxidative stress apoptosis |
| url | https://www.mdpi.com/2076-3921/9/6/459 |
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