Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease
To investigate the association of body weight variability (BWV) with adverse cardiovascular (CV) outcomes in patient with pre-dialysis chronic kidney disease (CKD), a total of 1867 participants with pre-dialysis CKD from Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-...
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MDPI AG
2021-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/10/3381 |
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| author | Sang Heon Suh Tae Ryom Oh Hong Sang Choi Chang Seong Kim Eun Hui Bae Sue K. Park Yong-Soo Kim Yeong Hoon Kim Kyu Hun Choi Kook-Hwan Oh Seong Kwon Ma Soo Wan Kim on behalf of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) Investigators |
| author_facet | Sang Heon Suh Tae Ryom Oh Hong Sang Choi Chang Seong Kim Eun Hui Bae Sue K. Park Yong-Soo Kim Yeong Hoon Kim Kyu Hun Choi Kook-Hwan Oh Seong Kwon Ma Soo Wan Kim on behalf of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) Investigators |
| author_sort | Sang Heon Suh |
| collection | DOAJ |
| description | To investigate the association of body weight variability (BWV) with adverse cardiovascular (CV) outcomes in patient with pre-dialysis chronic kidney disease (CKD), a total of 1867 participants with pre-dialysis CKD from Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) were analyzed. BWV was defined as the average absolute difference between successive values. The primary outcome was a composite of non-fatal CV events and all-cause mortality. Secondary outcomes were fatal and non-fatal CV events and all-cause mortality. High BWV was associated with increased risk of the composite outcome (adjusted hazard ratio (HR) 1.745, 95% confidence interval (CI) 1.065 to 2.847) as well as fatal and non-fatal CV events (adjusted HR 1.845, 95% CI 1.136 to 2.996) and all-cause mortality (adjusted HR 1.861, 95% CI 1.101 to 3.145). High BWV was associated with increased risk of fatal and non-fatal CV events, even in subjects without significant body weight gain or loss during follow-up periods (adjusted HR 2.755, 95% CI 1.114 to 6.813). In conclusion, high BWV is associated with adverse CV outcomes in patients with pre-dialysis CKD. |
| first_indexed | 2024-03-10T06:19:20Z |
| format | Article |
| id | doaj.art-8e777a989fc14bee8575d60d6c0d7498 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T06:19:20Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-8e777a989fc14bee8575d60d6c0d74982023-11-22T19:27:40ZengMDPI AGNutrients2072-66432021-09-011310338110.3390/nu13103381Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney DiseaseSang Heon Suh0Tae Ryom Oh1Hong Sang Choi2Chang Seong Kim3Eun Hui Bae4Sue K. Park5Yong-Soo Kim6Yeong Hoon Kim7Kyu Hun Choi8Kook-Hwan Oh9Seong Kwon Ma10Soo Wan Kim11on behalf of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) Investigators Department of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul 06591, KoreaDepartment of Internal Medicine, Busan Paik Hospital, College of Medicine, Inje University, Busan 47392, KoreaDepartment of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul 03722, KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul 03080, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaDepartment of Internal Medicine, Chonnam National University Medical School and Chonnam National University Hospital, Gwangju 61469, KoreaTo investigate the association of body weight variability (BWV) with adverse cardiovascular (CV) outcomes in patient with pre-dialysis chronic kidney disease (CKD), a total of 1867 participants with pre-dialysis CKD from Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) were analyzed. BWV was defined as the average absolute difference between successive values. The primary outcome was a composite of non-fatal CV events and all-cause mortality. Secondary outcomes were fatal and non-fatal CV events and all-cause mortality. High BWV was associated with increased risk of the composite outcome (adjusted hazard ratio (HR) 1.745, 95% confidence interval (CI) 1.065 to 2.847) as well as fatal and non-fatal CV events (adjusted HR 1.845, 95% CI 1.136 to 2.996) and all-cause mortality (adjusted HR 1.861, 95% CI 1.101 to 3.145). High BWV was associated with increased risk of fatal and non-fatal CV events, even in subjects without significant body weight gain or loss during follow-up periods (adjusted HR 2.755, 95% CI 1.114 to 6.813). In conclusion, high BWV is associated with adverse CV outcomes in patients with pre-dialysis CKD.https://www.mdpi.com/2072-6643/13/10/3381all-cause mortalitybody weight variabilitycardiovascular eventschronic kidney disease |
| spellingShingle | Sang Heon Suh Tae Ryom Oh Hong Sang Choi Chang Seong Kim Eun Hui Bae Sue K. Park Yong-Soo Kim Yeong Hoon Kim Kyu Hun Choi Kook-Hwan Oh Seong Kwon Ma Soo Wan Kim on behalf of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) Investigators Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease Nutrients all-cause mortality body weight variability cardiovascular events chronic kidney disease |
| title | Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease |
| title_full | Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease |
| title_fullStr | Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease |
| title_full_unstemmed | Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease |
| title_short | Association of Body Weight Variability with Adverse Cardiovascular Outcomes in Patients with Pre-Dialysis Chronic Kidney Disease |
| title_sort | association of body weight variability with adverse cardiovascular outcomes in patients with pre dialysis chronic kidney disease |
| topic | all-cause mortality body weight variability cardiovascular events chronic kidney disease |
| url | https://www.mdpi.com/2072-6643/13/10/3381 |
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