Lyme Disease: A Role for Coenzyme Q10 Supplementation?
Lyme disease results from a bacterial infection following a bite from an infected tick. Patients are initially treated with antibiotics; however, in cases where antibiotic treatment is delayed, or when patients do not respond to antibiotic treatment, fatigue may develop alongside problems affecting...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/4/667 |
| _version_ | 1827621929065906176 |
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| author | David Mantle Nadia Turton Iain P. Hargreaves |
| author_facet | David Mantle Nadia Turton Iain P. Hargreaves |
| author_sort | David Mantle |
| collection | DOAJ |
| description | Lyme disease results from a bacterial infection following a bite from an infected tick. Patients are initially treated with antibiotics; however, in cases where antibiotic treatment is delayed, or when patients do not respond to antibiotic treatment, fatigue may develop alongside problems affecting the nervous system, cardiovascular system, and joints. It is thought that most of the damage to these tissues results from the excessive inflammatory response of the host, involving a self-reinforcing cycle of mitochondrial dysfunction, oxidative stress and inflammation. In this article, we review the potential role of supplementary coenzyme Q10 (CoQ10) in mediating the pathogenic mechanism underlying Lyme disease, on the basis of its role in mitochondrial function, as well as its anti-inflammatory and antioxidant actions. |
| first_indexed | 2024-03-09T11:14:08Z |
| format | Article |
| id | doaj.art-8e7829efff6c4b8aa5b003197e364367 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T11:14:08Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-8e7829efff6c4b8aa5b003197e3643672023-12-01T00:34:41ZengMDPI AGAntioxidants2076-39212022-03-0111466710.3390/antiox11040667Lyme Disease: A Role for Coenzyme Q10 Supplementation?David Mantle0Nadia Turton1Iain P. Hargreaves2Pharma Nord (UK) Ltd., Newcastle NE61 2DB, UKSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UKSchool of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool L3 3AF, UKLyme disease results from a bacterial infection following a bite from an infected tick. Patients are initially treated with antibiotics; however, in cases where antibiotic treatment is delayed, or when patients do not respond to antibiotic treatment, fatigue may develop alongside problems affecting the nervous system, cardiovascular system, and joints. It is thought that most of the damage to these tissues results from the excessive inflammatory response of the host, involving a self-reinforcing cycle of mitochondrial dysfunction, oxidative stress and inflammation. In this article, we review the potential role of supplementary coenzyme Q10 (CoQ10) in mediating the pathogenic mechanism underlying Lyme disease, on the basis of its role in mitochondrial function, as well as its anti-inflammatory and antioxidant actions.https://www.mdpi.com/2076-3921/11/4/667Lyme diseasecoenzyme Q10fatigueinflammationoxidative stress |
| spellingShingle | David Mantle Nadia Turton Iain P. Hargreaves Lyme Disease: A Role for Coenzyme Q10 Supplementation? Antioxidants Lyme disease coenzyme Q10 fatigue inflammation oxidative stress |
| title | Lyme Disease: A Role for Coenzyme Q10 Supplementation? |
| title_full | Lyme Disease: A Role for Coenzyme Q10 Supplementation? |
| title_fullStr | Lyme Disease: A Role for Coenzyme Q10 Supplementation? |
| title_full_unstemmed | Lyme Disease: A Role for Coenzyme Q10 Supplementation? |
| title_short | Lyme Disease: A Role for Coenzyme Q10 Supplementation? |
| title_sort | lyme disease a role for coenzyme q10 supplementation |
| topic | Lyme disease coenzyme Q10 fatigue inflammation oxidative stress |
| url | https://www.mdpi.com/2076-3921/11/4/667 |
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