Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization
Abstract The mechanical strength of hydrogel microstructures is crucial for obtaining the desired flexibility, robustness, and biocompatibility for various applications such as cell scaffolds and soft microrobots. In this study, we demonstrate the fabrication of microstructures composed of cellulose...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-90445-7 |
| _version_ | 1818751143041302528 |
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| author | Hiroki Sugiyama Kaneto Tsunemitsu Hiroaki Onoe Kotaro Obata Koji Sugioka Mitsuhiro Terakawa |
| author_facet | Hiroki Sugiyama Kaneto Tsunemitsu Hiroaki Onoe Kotaro Obata Koji Sugioka Mitsuhiro Terakawa |
| author_sort | Hiroki Sugiyama |
| collection | DOAJ |
| description | Abstract The mechanical strength of hydrogel microstructures is crucial for obtaining the desired flexibility, robustness, and biocompatibility for various applications such as cell scaffolds and soft microrobots. In this study, we demonstrate the fabrication of microstructures composed of cellulose nanofibers (CNFs) and poly(ethylene glycol) diacrylate (PEGDA) hydrogels by multiphoton polymerization. The stress of the fabricated microstructure during tensile testing increased with an increase in the CNF concentration, indicating that the mechanical strength of the microstructure was enhanced by using CNFs as fillers. Moreover, the swelling ratio of the microstructure increased with increasing CNF concentration in the PEGDA hydrogel. Our results show the potential of the technique for the microfabrication of advanced cell scaffolds and soft microrobots with the desired mechanical strength. |
| first_indexed | 2024-12-18T04:30:53Z |
| format | Article |
| id | doaj.art-8e788dfb178c435ab418abd6b7fdae18 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T04:30:53Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8e788dfb178c435ab418abd6b7fdae182022-12-21T21:20:59ZengNature PortfolioScientific Reports2045-23222021-05-011111810.1038/s41598-021-90445-7Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerizationHiroki Sugiyama0Kaneto Tsunemitsu1Hiroaki Onoe2Kotaro Obata3Koji Sugioka4Mitsuhiro Terakawa5School of Integrated Design Engineering, Keio UniversitySchool of Integrated Design Engineering, Keio UniversitySchool of Integrated Design Engineering, Keio UniversityAdvanced Laser Processing Research Team, RIKEN Center for Advanced Photonics, RIKENAdvanced Laser Processing Research Team, RIKEN Center for Advanced Photonics, RIKENSchool of Integrated Design Engineering, Keio UniversityAbstract The mechanical strength of hydrogel microstructures is crucial for obtaining the desired flexibility, robustness, and biocompatibility for various applications such as cell scaffolds and soft microrobots. In this study, we demonstrate the fabrication of microstructures composed of cellulose nanofibers (CNFs) and poly(ethylene glycol) diacrylate (PEGDA) hydrogels by multiphoton polymerization. The stress of the fabricated microstructure during tensile testing increased with an increase in the CNF concentration, indicating that the mechanical strength of the microstructure was enhanced by using CNFs as fillers. Moreover, the swelling ratio of the microstructure increased with increasing CNF concentration in the PEGDA hydrogel. Our results show the potential of the technique for the microfabrication of advanced cell scaffolds and soft microrobots with the desired mechanical strength.https://doi.org/10.1038/s41598-021-90445-7 |
| spellingShingle | Hiroki Sugiyama Kaneto Tsunemitsu Hiroaki Onoe Kotaro Obata Koji Sugioka Mitsuhiro Terakawa Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization Scientific Reports |
| title | Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization |
| title_full | Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization |
| title_fullStr | Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization |
| title_full_unstemmed | Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization |
| title_short | Microfabrication of cellulose nanofiber-reinforced hydrogel by multiphoton polymerization |
| title_sort | microfabrication of cellulose nanofiber reinforced hydrogel by multiphoton polymerization |
| url | https://doi.org/10.1038/s41598-021-90445-7 |
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