Selective ablation of thymic and peripheral Foxp3+ regulatory T cell development

Selective ablation of thymic and peripheral Foxp3+ regulatory T cell development

Foxp3+ regulatory T (Treg) cells of thymic (tTreg) and peripheral (pTreg) developmental origin are thought to synergistically act to ensure immune homeostasis, with self-reactive tTreg cells primarily constraining autoimmune responses. Here we exploited a Foxp3-dependent reporter with thymus-specifi...

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Bibliographic Details
Main Authors: Acelya Yilmazer, Dimitra Maria Zevla, Rikke Malmkvist, Carlos Alejandro Bello Rodríguez, Pablo Undurraga, Emre Kirgin, Marie Boernert, David Voehringer, Olivia Kershaw, Susan Schlenner, Karsten Kretschmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
immune tolerance
autoimmunity
scurfy
diabetes
T cell development
pTreg
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1298938/full

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