The Clinical Significance of Unknown Sequence Variants in BRCA Genes

The Clinical Significance of Unknown Sequence Variants in BRCA Genes

Germline mutations in BRCA1/2 genes are responsible for a large proportion of hereditary breast and/or ovarian cancers. Many highly penetrant predisposition alleles have been identified and include frameshift or nonsense mutations that lead to the translation of a truncated protein. Other alleles co...

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Bibliographic Details
Main Authors: Antonio Russo, Valentina Calò, Loredana Bruno, Laura La Paglia, Marco Perez, Naomi Margarese, Francesca Di Gaudio
Format: Article
Language:English
Published: MDPI AG 2010-09-01
Series:Cancers
Subjects:
BRCA genes
variant
integrated models
oncogenetic counseling
Online Access:http://www.mdpi.com/2072-6694/2/3/1644/

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