THE ROLE OF THE CAROTID DOPPLER EXAMINATION IN THE EVALUATION OF ATHEROSCLEROTIC CHANGES IN BETA THALASSEMIA PATIENTS
Iron over- load in patients with beta-thalassemia major lead to alterations in the arterial structures and in the thickness of the carotid arteries. Doppler ultrasound scanning of extra-cranial internal carotid arteries is non-invasive and fairly quick to perform and may identify children at increas...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2015-02-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2139 |
| _version_ | 1819003688381841408 |
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| author | Gehan Lotfy Abdel Hakeem hoda Abdel kereem Abdel Samei Ashraf mohamed El Shereif Ahlam mohamed ismail |
| author_facet | Gehan Lotfy Abdel Hakeem hoda Abdel kereem Abdel Samei Ashraf mohamed El Shereif Ahlam mohamed ismail |
| author_sort | Gehan Lotfy Abdel Hakeem |
| collection | DOAJ |
| description | Iron over- load in patients with beta-thalassemia major lead to alterations in the arterial structures and in the thickness of the carotid arteries. Doppler ultrasound scanning of extra-cranial internal carotid arteries is non-invasive and fairly quick to perform and may identify children at increased risk of stroke who would otherwise be missed. Increased carotid artery intima media thickness (cIMT) is a structural marker for early atherosclerosis and it correlates with the vascular risk factors and to the severity and extent of coronary artery disease.
Objective: To evaluate the role of carotid Doppler examination and cIMT measurement as a predictive to atherosclerotic changes in BTM children with iron overload.
Patients and Methods: Sixty two children with (BTM) and 30 healthy normal controls of matched age and sex were included. Complete blood count, serum iron, ferritin, serum cholesterol and hemoglobin electrophoresis were performed as well as carotid Doppler ultrasonography to measure the (cIMT) in both patients and controls. Results: By using carotid Doppler we found that cIMT of thalassemic patients was significantly increased compared to normal controls and there was significant positive correlation between CIMT and patient's age, weight, height, BMI, duration of illness, serum cholesterol, iron overload parameters as serum iron, serum ferritin, frequent blood transfusion, irregular use of iron chelating agents and in those who had splenectomy. Significant negative correlation was found between CIMT and hematocrit value but no significant correlation was found between CIMT and Hb level. Conclusion: Carotid Doppler is very useful method in measurement of cIMT that increased in thalassemic patients which shows a strong relationship with features of iron overload. We recommend the routine use of Doppler measurement of cIMT in these patients to predict early atherosclerotic changes as well as in the follow-up to prevent progression of atherosclerosis. |
| first_indexed | 2024-12-20T23:24:59Z |
| format | Article |
| id | doaj.art-8e7e1e68e8c742288895a45cd84c3b50 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2024-12-20T23:24:59Z |
| publishDate | 2015-02-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-8e7e1e68e8c742288895a45cd84c3b502022-12-21T19:23:25ZengMattioli1885Mediterranean Journal of Hematology and Infectious Diseases2035-30062015-02-0171e2015023e201502310.4084/mjhid.2015.0231549THE ROLE OF THE CAROTID DOPPLER EXAMINATION IN THE EVALUATION OF ATHEROSCLEROTIC CHANGES IN BETA THALASSEMIA PATIENTSGehan Lotfy Abdel Hakeem0hoda Abdel kereem Abdel Samei1Ashraf mohamed El Shereif2Ahlam mohamed ismail3EL Menia university, faculty of medicine, pediatric dep.lecturer of radiology, radiology department, South Vally universityprof. of radiology,radiology department, Menia universitylecturer of pediatric, South Vally universityIron over- load in patients with beta-thalassemia major lead to alterations in the arterial structures and in the thickness of the carotid arteries. Doppler ultrasound scanning of extra-cranial internal carotid arteries is non-invasive and fairly quick to perform and may identify children at increased risk of stroke who would otherwise be missed. Increased carotid artery intima media thickness (cIMT) is a structural marker for early atherosclerosis and it correlates with the vascular risk factors and to the severity and extent of coronary artery disease. Objective: To evaluate the role of carotid Doppler examination and cIMT measurement as a predictive to atherosclerotic changes in BTM children with iron overload. Patients and Methods: Sixty two children with (BTM) and 30 healthy normal controls of matched age and sex were included. Complete blood count, serum iron, ferritin, serum cholesterol and hemoglobin electrophoresis were performed as well as carotid Doppler ultrasonography to measure the (cIMT) in both patients and controls. Results: By using carotid Doppler we found that cIMT of thalassemic patients was significantly increased compared to normal controls and there was significant positive correlation between CIMT and patient's age, weight, height, BMI, duration of illness, serum cholesterol, iron overload parameters as serum iron, serum ferritin, frequent blood transfusion, irregular use of iron chelating agents and in those who had splenectomy. Significant negative correlation was found between CIMT and hematocrit value but no significant correlation was found between CIMT and Hb level. Conclusion: Carotid Doppler is very useful method in measurement of cIMT that increased in thalassemic patients which shows a strong relationship with features of iron overload. We recommend the routine use of Doppler measurement of cIMT in these patients to predict early atherosclerotic changes as well as in the follow-up to prevent progression of atherosclerosis.http://www.mjhid.org/index.php/mjhid/article/view/2139carotid Doppler, thalasssemia , iron overload, atherosclerosis. |
| spellingShingle | Gehan Lotfy Abdel Hakeem hoda Abdel kereem Abdel Samei Ashraf mohamed El Shereif Ahlam mohamed ismail THE ROLE OF THE CAROTID DOPPLER EXAMINATION IN THE EVALUATION OF ATHEROSCLEROTIC CHANGES IN BETA THALASSEMIA PATIENTS Mediterranean Journal of Hematology and Infectious Diseases carotid Doppler, thalasssemia , iron overload, atherosclerosis. |
| title | THE ROLE OF THE CAROTID DOPPLER EXAMINATION IN THE EVALUATION OF ATHEROSCLEROTIC CHANGES IN BETA THALASSEMIA PATIENTS |
| title_full | THE ROLE OF THE CAROTID DOPPLER EXAMINATION IN THE EVALUATION OF ATHEROSCLEROTIC CHANGES IN BETA THALASSEMIA PATIENTS |
| title_fullStr | THE ROLE OF THE CAROTID DOPPLER EXAMINATION IN THE EVALUATION OF ATHEROSCLEROTIC CHANGES IN BETA THALASSEMIA PATIENTS |
| title_full_unstemmed | THE ROLE OF THE CAROTID DOPPLER EXAMINATION IN THE EVALUATION OF ATHEROSCLEROTIC CHANGES IN BETA THALASSEMIA PATIENTS |
| title_short | THE ROLE OF THE CAROTID DOPPLER EXAMINATION IN THE EVALUATION OF ATHEROSCLEROTIC CHANGES IN BETA THALASSEMIA PATIENTS |
| title_sort | role of the carotid doppler examination in the evaluation of atherosclerotic changes in beta thalassemia patients |
| topic | carotid Doppler, thalasssemia , iron overload, atherosclerosis. |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2139 |
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