NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma

NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma

Multiple myeloma (MM) is still an incurable hematologic malignancy, which is eagerly to the discovery of novel therapeutic targets and methods. N-acetyltransferase 10 (NAT10) is the first reported regulator of mRNA acetylation that is activated in many cancers. However, the function of NAT10 in MM r...

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Bibliographic Details
Main Authors: Rongfang Wei, Xing Cui, Jie Min, Zigen Lin, Yanyan Zhou, Mengjie Guo, Xiaojuan An, Hao Liu, Siegfried Janz, Chunyan Gu, Hongbo Wang, Ye Yang
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Multiple myeloma
Target
NAT10
Acetylation
CEP170
Chromosomal instability
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522000429

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