Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction
Pelvic organ prolapse (POP) is a hidden women’s health disorder that impacts 1 in 4 women across all age groups. Surgical intervention has been the only treatment option, often involving non-degradable meshes, with variable results. However, recent reports have highlighted the adverse effects of mes...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/10/6/1120 |
| _version_ | 1797566025721446400 |
|---|---|
| author | Kallyanashis Paul Saeedeh Darzi Jerome A. Werkmeister Caroline E. Gargett Shayanti Mukherjee |
| author_facet | Kallyanashis Paul Saeedeh Darzi Jerome A. Werkmeister Caroline E. Gargett Shayanti Mukherjee |
| author_sort | Kallyanashis Paul |
| collection | DOAJ |
| description | Pelvic organ prolapse (POP) is a hidden women’s health disorder that impacts 1 in 4 women across all age groups. Surgical intervention has been the only treatment option, often involving non-degradable meshes, with variable results. However, recent reports have highlighted the adverse effects of meshes in the long term, which involve unacceptable rates of erosion, chronic infection and severe pain related to mesh shrinkage. Therefore, there is an urgent unmet need to fabricate of new class of biocompatible meshes for the treatment of POP. This review focuses on the causes for the downfall of commercial meshes, and discusses the use of emerging technologies such as electrospinning and 3D printing to design new meshes. Furthermore, we discuss the impact and advantage of nano-/microstructured alternative meshes over commercial meshes with respect to their tissue integration performance. Considering the key challenges of current meshes, we discuss the potential of cell-based tissue engineering strategies to augment the new class of meshes to improve biocompatibility and immunomodulation. Finally, this review highlights the future direction in designing the new class of mesh to overcome the hurdles of foreign body rejection faced by the traditional meshes, in order to have safe and effective treatment for women in the long term. |
| first_indexed | 2024-03-10T19:21:01Z |
| format | Article |
| id | doaj.art-8e82e41ef2604f6a90f5383b5069e130 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T19:21:01Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-8e82e41ef2604f6a90f5383b5069e1302023-11-20T02:59:21ZengMDPI AGNanomaterials2079-49912020-06-01106112010.3390/nano10061120Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor ReconstructionKallyanashis Paul0Saeedeh Darzi1Jerome A. Werkmeister2Caroline E. Gargett3Shayanti Mukherjee4The Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, AustraliaThe Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, AustraliaThe Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, AustraliaThe Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, AustraliaThe Ritchie Centre, Hudson Institute of Medical Research, Clayton 3168, AustraliaPelvic organ prolapse (POP) is a hidden women’s health disorder that impacts 1 in 4 women across all age groups. Surgical intervention has been the only treatment option, often involving non-degradable meshes, with variable results. However, recent reports have highlighted the adverse effects of meshes in the long term, which involve unacceptable rates of erosion, chronic infection and severe pain related to mesh shrinkage. Therefore, there is an urgent unmet need to fabricate of new class of biocompatible meshes for the treatment of POP. This review focuses on the causes for the downfall of commercial meshes, and discusses the use of emerging technologies such as electrospinning and 3D printing to design new meshes. Furthermore, we discuss the impact and advantage of nano-/microstructured alternative meshes over commercial meshes with respect to their tissue integration performance. Considering the key challenges of current meshes, we discuss the potential of cell-based tissue engineering strategies to augment the new class of meshes to improve biocompatibility and immunomodulation. Finally, this review highlights the future direction in designing the new class of mesh to overcome the hurdles of foreign body rejection faced by the traditional meshes, in order to have safe and effective treatment for women in the long term.https://www.mdpi.com/2079-4991/10/6/1120pelvic organ prolapsemesh complicationsnanofiber mesh3D printingforeign body responsecell therapy |
| spellingShingle | Kallyanashis Paul Saeedeh Darzi Jerome A. Werkmeister Caroline E. Gargett Shayanti Mukherjee Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction Nanomaterials pelvic organ prolapse mesh complications nanofiber mesh 3D printing foreign body response cell therapy |
| title | Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction |
| title_full | Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction |
| title_fullStr | Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction |
| title_full_unstemmed | Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction |
| title_short | Emerging Nano/Micro-Structured Degradable Polymeric Meshes for Pelvic Floor Reconstruction |
| title_sort | emerging nano micro structured degradable polymeric meshes for pelvic floor reconstruction |
| topic | pelvic organ prolapse mesh complications nanofiber mesh 3D printing foreign body response cell therapy |
| url | https://www.mdpi.com/2079-4991/10/6/1120 |
| work_keys_str_mv | AT kallyanashispaul emergingnanomicrostructureddegradablepolymericmeshesforpelvicfloorreconstruction AT saeedehdarzi emergingnanomicrostructureddegradablepolymericmeshesforpelvicfloorreconstruction AT jeromeawerkmeister emergingnanomicrostructureddegradablepolymericmeshesforpelvicfloorreconstruction AT carolineegargett emergingnanomicrostructureddegradablepolymericmeshesforpelvicfloorreconstruction AT shayantimukherjee emergingnanomicrostructureddegradablepolymericmeshesforpelvicfloorreconstruction |