The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of <i>Morus</i>
The root bark of <i>Morus</i> has long been appreciated as an antiphlogistic, diuretic and expectorant drug in Chinese herbal medicine, albeit with barely known targets and mechanisms of action. In the 1970s, the development of analytic chemistry allowed for the discovery of morusin as o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/18/6541 |
| _version_ | 1797554355204784128 |
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| author | Dong Wook Choi Sang Woo Cho Seok-Geun Lee Cheol Yong Choi |
| author_facet | Dong Wook Choi Sang Woo Cho Seok-Geun Lee Cheol Yong Choi |
| author_sort | Dong Wook Choi |
| collection | DOAJ |
| description | The root bark of <i>Morus</i> has long been appreciated as an antiphlogistic, diuretic and expectorant drug in Chinese herbal medicine, albeit with barely known targets and mechanisms of action. In the 1970s, the development of analytic chemistry allowed for the discovery of morusin as one of 7 different isoprene flavonoid derivatives in the root bark of <i>Morus</i>. However, the remarkable antioxidant capacity of morusin with the unexpected potential for health benefits over the other flavonoid derivatives has recently sparked scientific interest in the biochemical identification of target proteins and signaling pathways and further clinical relevance. In this review, we discuss recent advances in the understanding of the functional roles of morusin in multiple biological processes such as inflammation, apoptosis, metabolism and autophagy. We also highlight recent in vivo and in vitro evidence on the clinical potential of morusin treatment for multiple human pathologies including inflammatory diseases, neurological disorders, diabetes, cancer and the underlying mechanisms. |
| first_indexed | 2024-03-10T16:30:50Z |
| format | Article |
| id | doaj.art-8e83a56937914268a1bc138105c744b0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T16:30:50Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8e83a56937914268a1bc138105c744b02023-11-20T12:52:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-012118654110.3390/ijms21186541The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of <i>Morus</i>Dong Wook Choi0Sang Woo Cho1Seok-Geun Lee2Cheol Yong Choi3Department of Biological Sciences, Sungkyunkwan University, Suwon 16419, KoreaDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, KoreaDepartment of Science in Korean Medicine, Kyung Hee University, Seoul 02447, KoreaDepartment of Biological Sciences, Sungkyunkwan University, Suwon 16419, KoreaThe root bark of <i>Morus</i> has long been appreciated as an antiphlogistic, diuretic and expectorant drug in Chinese herbal medicine, albeit with barely known targets and mechanisms of action. In the 1970s, the development of analytic chemistry allowed for the discovery of morusin as one of 7 different isoprene flavonoid derivatives in the root bark of <i>Morus</i>. However, the remarkable antioxidant capacity of morusin with the unexpected potential for health benefits over the other flavonoid derivatives has recently sparked scientific interest in the biochemical identification of target proteins and signaling pathways and further clinical relevance. In this review, we discuss recent advances in the understanding of the functional roles of morusin in multiple biological processes such as inflammation, apoptosis, metabolism and autophagy. We also highlight recent in vivo and in vitro evidence on the clinical potential of morusin treatment for multiple human pathologies including inflammatory diseases, neurological disorders, diabetes, cancer and the underlying mechanisms.https://www.mdpi.com/1422-0067/21/18/6541morusinantioxidantsnatural productscell signalinginflammatory diseasesneurological disorders |
| spellingShingle | Dong Wook Choi Sang Woo Cho Seok-Geun Lee Cheol Yong Choi The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of <i>Morus</i> International Journal of Molecular Sciences morusin antioxidants natural products cell signaling inflammatory diseases neurological disorders |
| title | The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of <i>Morus</i> |
| title_full | The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of <i>Morus</i> |
| title_fullStr | The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of <i>Morus</i> |
| title_full_unstemmed | The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of <i>Morus</i> |
| title_short | The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of <i>Morus</i> |
| title_sort | beneficial effects of morusin an isoprene flavonoid isolated from the root bark of i morus i |
| topic | morusin antioxidants natural products cell signaling inflammatory diseases neurological disorders |
| url | https://www.mdpi.com/1422-0067/21/18/6541 |
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