Impact of access to treatment on patient‐reported outcomes among rheumatoid arthritis patients with tDMARDs and bDMARDS in two Latin‐American countries: A prospective observational study
Abstract Background and Aims A noninterventional prospective study was performed in Colombia and Peru. The aim was to describe the impact of access to treatment on Patient‐reported outcomes (PRO) in patients with Rheumatoid arthritis (RA) after failure to conventional disease‐modifying antirheumatic...
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1034 |
| _version_ | 1797859097370951680 |
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| author | Juan M. Reyes Magda V. Gutierrez‐Ardila Hugo Madariaga William Otero Renato Guzman Jorge Izquierdo David J. Del Castillo Mauricio Abello Patricia Velez Dario Ponce de Leon Tatjana Lukic Luisa F. Amador Natalia Castaño |
| author_facet | Juan M. Reyes Magda V. Gutierrez‐Ardila Hugo Madariaga William Otero Renato Guzman Jorge Izquierdo David J. Del Castillo Mauricio Abello Patricia Velez Dario Ponce de Leon Tatjana Lukic Luisa F. Amador Natalia Castaño |
| author_sort | Juan M. Reyes |
| collection | DOAJ |
| description | Abstract Background and Aims A noninterventional prospective study was performed in Colombia and Peru. The aim was to describe the impact of access to treatment on Patient‐reported outcomes (PRO) in patients with Rheumatoid arthritis (RA) after failure to conventional disease‐modifying antirheumatic drugs (DMARDs) in real‐life conditions. Methods The impact of access to treatment was measured by access barriers, time to supply (TtS) and interruption evaluating their effect in changes of PROs between baseline and 6‐month follow‐up between February 2017 and November 2019. The association of access to care with disease activity, functional status, health‐related quality of life was assessed using bivariate and multivariable analysis. Results are expressed in least mean difference; TtS in mean number of days for delivery of treatment at baseline. Variability measures were standard deviation and standard error. Results One hundred seventy patients were recruited, 70 treated with tofacitinib and 100 with biological DMARDs. Thirty‐nine patients reported access barriers. The mean of TtS was 23 ± 38.83 days. The difference from baseline to 6‐month visit in PROs were affected by access barriers and interruptions. There was not statistically significant difference in the of PRO's score among visits in patients that reported delay of supply of more than 23 days compared to patients with less days of delay. Conclusion This study suggested the access to treatment can affect the response to the treatment at 6 months of follow‐up. There seems to be no effect in the PROs for delay of TtS during the studied period. |
| first_indexed | 2024-04-09T21:23:58Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-04-09T21:23:58Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-8e84558703914c9580497121a51f64052023-03-28T02:18:38ZengWileyHealth Science Reports2398-88352023-03-0163n/an/a10.1002/hsr2.1034Impact of access to treatment on patient‐reported outcomes among rheumatoid arthritis patients with tDMARDs and bDMARDS in two Latin‐American countries: A prospective observational studyJuan M. Reyes0Magda V. Gutierrez‐Ardila1Hugo Madariaga2William Otero3Renato Guzman4Jorge Izquierdo5David J. Del Castillo6Mauricio Abello7Patricia Velez8Dario Ponce de Leon9Tatjana Lukic10Luisa F. Amador11Natalia Castaño12Pfizer Bogota ColombiaPfizer Santiago ChileCentro Médico CEEN Arequipa PeruCentro Servimed Bucaramanga ColombiaCentro IDEARG Bogotá ColombiaClínica del Occidente Cali ColombiaClínica del Occidente Cali ColombiaCentro Integral de Reumatología Circaribe Barranquilla ColombiaCentro Médico CIREEM Bogota ColombiaPfizer Lima PeruPfizer Inc New York USAPfizer Bogota ColombiaPfizer Bogota ColombiaAbstract Background and Aims A noninterventional prospective study was performed in Colombia and Peru. The aim was to describe the impact of access to treatment on Patient‐reported outcomes (PRO) in patients with Rheumatoid arthritis (RA) after failure to conventional disease‐modifying antirheumatic drugs (DMARDs) in real‐life conditions. Methods The impact of access to treatment was measured by access barriers, time to supply (TtS) and interruption evaluating their effect in changes of PROs between baseline and 6‐month follow‐up between February 2017 and November 2019. The association of access to care with disease activity, functional status, health‐related quality of life was assessed using bivariate and multivariable analysis. Results are expressed in least mean difference; TtS in mean number of days for delivery of treatment at baseline. Variability measures were standard deviation and standard error. Results One hundred seventy patients were recruited, 70 treated with tofacitinib and 100 with biological DMARDs. Thirty‐nine patients reported access barriers. The mean of TtS was 23 ± 38.83 days. The difference from baseline to 6‐month visit in PROs were affected by access barriers and interruptions. There was not statistically significant difference in the of PRO's score among visits in patients that reported delay of supply of more than 23 days compared to patients with less days of delay. Conclusion This study suggested the access to treatment can affect the response to the treatment at 6 months of follow‐up. There seems to be no effect in the PROs for delay of TtS during the studied period.https://doi.org/10.1002/hsr2.1034bDMARDs (biologic)disease activityhealthcare accessLatin Americanrheumatoid arthritistofacitinib |
| spellingShingle | Juan M. Reyes Magda V. Gutierrez‐Ardila Hugo Madariaga William Otero Renato Guzman Jorge Izquierdo David J. Del Castillo Mauricio Abello Patricia Velez Dario Ponce de Leon Tatjana Lukic Luisa F. Amador Natalia Castaño Impact of access to treatment on patient‐reported outcomes among rheumatoid arthritis patients with tDMARDs and bDMARDS in two Latin‐American countries: A prospective observational study Health Science Reports bDMARDs (biologic) disease activity healthcare access Latin American rheumatoid arthritis tofacitinib |
| title | Impact of access to treatment on patient‐reported outcomes among rheumatoid arthritis patients with tDMARDs and bDMARDS in two Latin‐American countries: A prospective observational study |
| title_full | Impact of access to treatment on patient‐reported outcomes among rheumatoid arthritis patients with tDMARDs and bDMARDS in two Latin‐American countries: A prospective observational study |
| title_fullStr | Impact of access to treatment on patient‐reported outcomes among rheumatoid arthritis patients with tDMARDs and bDMARDS in two Latin‐American countries: A prospective observational study |
| title_full_unstemmed | Impact of access to treatment on patient‐reported outcomes among rheumatoid arthritis patients with tDMARDs and bDMARDS in two Latin‐American countries: A prospective observational study |
| title_short | Impact of access to treatment on patient‐reported outcomes among rheumatoid arthritis patients with tDMARDs and bDMARDS in two Latin‐American countries: A prospective observational study |
| title_sort | impact of access to treatment on patient reported outcomes among rheumatoid arthritis patients with tdmards and bdmards in two latin american countries a prospective observational study |
| topic | bDMARDs (biologic) disease activity healthcare access Latin American rheumatoid arthritis tofacitinib |
| url | https://doi.org/10.1002/hsr2.1034 |
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