Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrest
Objective To investigate whether serum levels of high-density lipoprotein (HDL) and apolipoprotein A-1 (ApoA1), after the return of spontaneous circulation, can predict the neurologic outcome in patients with out-of-hospital cardiac arrest (OHCA). Methods This was a retrospective observational study...
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| Format: | Article |
| Language: | English |
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The Korean Society of Emergency Medicine
2017-12-01
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| Series: | Clinical and Experimental Emergency Medicine |
| Subjects: | |
| Online Access: | http://www.ceemjournal.org/upload/pdf/ceem-16-164.pdf |
| _version_ | 1828005377512308736 |
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| author | Yong Soo Son Kyung Su Kim Gil Joon Suh Woon Yong Kwon Min Ji Park Jung In Ko Taegyun Kim |
| author_facet | Yong Soo Son Kyung Su Kim Gil Joon Suh Woon Yong Kwon Min Ji Park Jung In Ko Taegyun Kim |
| author_sort | Yong Soo Son |
| collection | DOAJ |
| description | Objective To investigate whether serum levels of high-density lipoprotein (HDL) and apolipoprotein A-1 (ApoA1), after the return of spontaneous circulation, can predict the neurologic outcome in patients with out-of-hospital cardiac arrest (OHCA). Methods This was a retrospective observational study conducted in a single tertiary hospital intensive care unit. All adult OHCA survivors with admission lipid profiles were enrolled from March 2013 to December 2015. Good neurologic outcome was defined as discharge cerebral performance categories 1 and 2. Results Among 59 patients enrolled, 13 (22.0%) had a good neurologic outcome. Serum levels of HDL (56.7 vs. 40 mg/dL) and ApoA1 (117 vs. 91.6 mg/dL) were significantly higher in patients with a good outcome. Areas under the HDL and ApoA1 receiver operating curves to predict good outcomes were 0.799 and 0.759, respectively. The proportion of good outcome was significantly higher in patients in higher tertiles of HDL and ApoA1 (test for trend, both P=0.003). HDL (P=0.018) was an independent predictor in the multivariate logistic regression model. Conclusion Admission levels of HDL and ApoA1 are associated with neurologic outcome in patients with OHCA. Prognostic and potential therapeutic values of HDL and ApoA1 merit further evaluation in the post-cardiac arrest state, as in other systemic inflammatory conditions such as sepsis. |
| first_indexed | 2024-04-10T07:29:55Z |
| format | Article |
| id | doaj.art-8e851c803c6d4d5eb3ce108de9ce8015 |
| institution | Directory Open Access Journal |
| issn | 2383-4625 |
| language | English |
| last_indexed | 2024-04-10T07:29:55Z |
| publishDate | 2017-12-01 |
| publisher | The Korean Society of Emergency Medicine |
| record_format | Article |
| series | Clinical and Experimental Emergency Medicine |
| spelling | doaj.art-8e851c803c6d4d5eb3ce108de9ce80152023-02-24T00:48:31ZengThe Korean Society of Emergency MedicineClinical and Experimental Emergency Medicine2383-46252017-12-014423223710.15441/ceem.16.164162Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrestYong Soo SonKyung Su KimGil Joon SuhWoon Yong KwonMin Ji ParkJung In KoTaegyun KimObjective To investigate whether serum levels of high-density lipoprotein (HDL) and apolipoprotein A-1 (ApoA1), after the return of spontaneous circulation, can predict the neurologic outcome in patients with out-of-hospital cardiac arrest (OHCA). Methods This was a retrospective observational study conducted in a single tertiary hospital intensive care unit. All adult OHCA survivors with admission lipid profiles were enrolled from March 2013 to December 2015. Good neurologic outcome was defined as discharge cerebral performance categories 1 and 2. Results Among 59 patients enrolled, 13 (22.0%) had a good neurologic outcome. Serum levels of HDL (56.7 vs. 40 mg/dL) and ApoA1 (117 vs. 91.6 mg/dL) were significantly higher in patients with a good outcome. Areas under the HDL and ApoA1 receiver operating curves to predict good outcomes were 0.799 and 0.759, respectively. The proportion of good outcome was significantly higher in patients in higher tertiles of HDL and ApoA1 (test for trend, both P=0.003). HDL (P=0.018) was an independent predictor in the multivariate logistic regression model. Conclusion Admission levels of HDL and ApoA1 are associated with neurologic outcome in patients with OHCA. Prognostic and potential therapeutic values of HDL and ApoA1 merit further evaluation in the post-cardiac arrest state, as in other systemic inflammatory conditions such as sepsis.http://www.ceemjournal.org/upload/pdf/ceem-16-164.pdfheart arrestcholesterol, hdlapolipoprotein a-1prognosis |
| spellingShingle | Yong Soo Son Kyung Su Kim Gil Joon Suh Woon Yong Kwon Min Ji Park Jung In Ko Taegyun Kim Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrest Clinical and Experimental Emergency Medicine heart arrest cholesterol, hdl apolipoprotein a-1 prognosis |
| title | Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrest |
| title_full | Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrest |
| title_fullStr | Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrest |
| title_full_unstemmed | Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrest |
| title_short | Admission levels of high-density lipoprotein and apolipoprotein A-1 are associated with the neurologic outcome in patients with out-of-hospital cardiac arrest |
| title_sort | admission levels of high density lipoprotein and apolipoprotein a 1 are associated with the neurologic outcome in patients with out of hospital cardiac arrest |
| topic | heart arrest cholesterol, hdl apolipoprotein a-1 prognosis |
| url | http://www.ceemjournal.org/upload/pdf/ceem-16-164.pdf |
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