Management of Plaque Psoriasis in Adults: Clinical Utility of Tapinarof Cream
Riley K Spencer,1,2 Joy Q Jin,2,3 Kareem G Elhage,2 Mitchell S Davis,2 Wilson Liao,2 Tina Bhutani2 1Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA; 2Department of Dermatology, University of California at San Francisco, San Francisco, CA, USA; 3School of Medicine, U...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-10-01
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| Series: | Psoriasis: Targets and Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/management-of-plaque-psoriasis-in-adults-clinical-utility-of-tapinarof-peer-reviewed-fulltext-article-PTT |
| _version_ | 1827782669908312064 |
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| author | Spencer RK Jin JQ Elhage KG Davis MS Liao W Bhutani T |
| author_facet | Spencer RK Jin JQ Elhage KG Davis MS Liao W Bhutani T |
| author_sort | Spencer RK |
| collection | DOAJ |
| description | Riley K Spencer,1,2 Joy Q Jin,2,3 Kareem G Elhage,2 Mitchell S Davis,2 Wilson Liao,2 Tina Bhutani2 1Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA; 2Department of Dermatology, University of California at San Francisco, San Francisco, CA, USA; 3School of Medicine, University of California at San Francisco, San Francisco, CA, USACorrespondence: Riley K Spencer, Department of Dermatology, University of California at San Francisco, Box 1212, Floor 01, Room 101, 2340 Sutter Street, San Francisco, CA, 94115, USA, Tel +1 480 415 7224, Fax +1 415 502 4126, Email rileykylespencer@gmail.comAbstract: Topical medications represent the most commonly used drugs in the treatment of psoriasis. However, topical steroids are mainly limited to short-term or intermittent use, and traditional non-steroidal topicals such as vitamin D analogues, topical calcineurin inhibitors, and topical retinoids are limited by low efficacy and poor local skin tolerability. Tapinarof (GSK2894512, DMVT-505) is a novel, topical aryl hydrocarbon receptor (AHR) agonist, which was recently approved by the FDA for the treatment of plaque psoriasis in adults. Tapinarof acts to improve psoriasis through diminished IL-17A production by CD4+ T cells, increased barrier gene expression in keratinocytes, and reduced production of reactive oxygen species. Both short-term and long-term efficacy and safety have been evaluated in two Phase II and two Phase III (PSOARING 1 and 2) clinical trials in addition to a long-term extension study (PSOARING 3). Overall, the drug has shown beneficial effects in achieving clear skin in adults with moderate-to-severe psoriasis, good local tolerability, and also a long duration of effect even after discontinuation of the drug. Therefore, this therapy provides a new, highly effective and safe non-steroidal option to add to our psoriasis treatment toolbox for both initial clearance and long-term maintenance of disease.Keywords: tapinarof, vtama, psoriasis, PSOARING |
| first_indexed | 2024-03-11T15:36:19Z |
| format | Article |
| id | doaj.art-8e86a99cfa254f25bfb75a091e8643cc |
| institution | Directory Open Access Journal |
| issn | 2230-326X |
| language | English |
| last_indexed | 2024-03-11T15:36:19Z |
| publishDate | 2023-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Psoriasis: Targets and Therapy |
| spelling | doaj.art-8e86a99cfa254f25bfb75a091e8643cc2023-10-26T17:06:53ZengDove Medical PressPsoriasis: Targets and Therapy2230-326X2023-10-01Volume 13596987606Management of Plaque Psoriasis in Adults: Clinical Utility of Tapinarof CreamSpencer RKJin JQElhage KGDavis MSLiao WBhutani TRiley K Spencer,1,2 Joy Q Jin,2,3 Kareem G Elhage,2 Mitchell S Davis,2 Wilson Liao,2 Tina Bhutani2 1Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA; 2Department of Dermatology, University of California at San Francisco, San Francisco, CA, USA; 3School of Medicine, University of California at San Francisco, San Francisco, CA, USACorrespondence: Riley K Spencer, Department of Dermatology, University of California at San Francisco, Box 1212, Floor 01, Room 101, 2340 Sutter Street, San Francisco, CA, 94115, USA, Tel +1 480 415 7224, Fax +1 415 502 4126, Email rileykylespencer@gmail.comAbstract: Topical medications represent the most commonly used drugs in the treatment of psoriasis. However, topical steroids are mainly limited to short-term or intermittent use, and traditional non-steroidal topicals such as vitamin D analogues, topical calcineurin inhibitors, and topical retinoids are limited by low efficacy and poor local skin tolerability. Tapinarof (GSK2894512, DMVT-505) is a novel, topical aryl hydrocarbon receptor (AHR) agonist, which was recently approved by the FDA for the treatment of plaque psoriasis in adults. Tapinarof acts to improve psoriasis through diminished IL-17A production by CD4+ T cells, increased barrier gene expression in keratinocytes, and reduced production of reactive oxygen species. Both short-term and long-term efficacy and safety have been evaluated in two Phase II and two Phase III (PSOARING 1 and 2) clinical trials in addition to a long-term extension study (PSOARING 3). Overall, the drug has shown beneficial effects in achieving clear skin in adults with moderate-to-severe psoriasis, good local tolerability, and also a long duration of effect even after discontinuation of the drug. Therefore, this therapy provides a new, highly effective and safe non-steroidal option to add to our psoriasis treatment toolbox for both initial clearance and long-term maintenance of disease.Keywords: tapinarof, vtama, psoriasis, PSOARINGhttps://www.dovepress.com/management-of-plaque-psoriasis-in-adults-clinical-utility-of-tapinarof-peer-reviewed-fulltext-article-PTTtapinarofpsoriasisvtamapsoaring |
| spellingShingle | Spencer RK Jin JQ Elhage KG Davis MS Liao W Bhutani T Management of Plaque Psoriasis in Adults: Clinical Utility of Tapinarof Cream Psoriasis: Targets and Therapy tapinarof psoriasis vtama psoaring |
| title | Management of Plaque Psoriasis in Adults: Clinical Utility of Tapinarof Cream |
| title_full | Management of Plaque Psoriasis in Adults: Clinical Utility of Tapinarof Cream |
| title_fullStr | Management of Plaque Psoriasis in Adults: Clinical Utility of Tapinarof Cream |
| title_full_unstemmed | Management of Plaque Psoriasis in Adults: Clinical Utility of Tapinarof Cream |
| title_short | Management of Plaque Psoriasis in Adults: Clinical Utility of Tapinarof Cream |
| title_sort | management of plaque psoriasis in adults clinical utility of tapinarof cream |
| topic | tapinarof psoriasis vtama psoaring |
| url | https://www.dovepress.com/management-of-plaque-psoriasis-in-adults-clinical-utility-of-tapinarof-peer-reviewed-fulltext-article-PTT |
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