Xishaeleganins A–D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge <i>Dactylospongia elegans</i>
Four new sesquiterpene hydroquinones, xishaeleganins A–D (<b>6</b>–<b>9</b>), along with eleven known related ones (<b>12</b> and <b>14</b>–<b>23</b>) were isolated from the Xisha marine sponge <i>Dactylospongia elegans</i> (fam...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/2/118 |
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| author | Bao Chen Qingmin Zhao Yu-Cheng Gu Lefu Lan Chang-Yun Wang Yue-Wei Guo |
| author_facet | Bao Chen Qingmin Zhao Yu-Cheng Gu Lefu Lan Chang-Yun Wang Yue-Wei Guo |
| author_sort | Bao Chen |
| collection | DOAJ |
| description | Four new sesquiterpene hydroquinones, xishaeleganins A–D (<b>6</b>–<b>9</b>), along with eleven known related ones (<b>12</b> and <b>14</b>–<b>23</b>) were isolated from the Xisha marine sponge <i>Dactylospongia elegans</i> (family Thorectida). Their structures were determined by extensive spectroscopic analysis, ECD calculations, and by comparison with the spectral data reported in the literature. Compounds <b>7</b>, <b>15</b>, <b>20</b>, and <b>21</b> showed significant antibacterial activity against <i>Staphylococcus aureus</i>, with minimum inhibitory concentration values of 1.5, 2.9, 5.6, and 5.6 µg/mL, which are comparable with those obtained for the positive control vancomycin (MIC: 1.0 µg/mL). |
| first_indexed | 2024-03-09T21:33:30Z |
| format | Article |
| id | doaj.art-8e880df5defe42de822d52ebee54d80f |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T21:33:30Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-8e880df5defe42de822d52ebee54d80f2023-11-23T20:50:08ZengMDPI AGMarine Drugs1660-33972022-02-0120211810.3390/md20020118Xishaeleganins A–D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge <i>Dactylospongia elegans</i>Bao Chen0Qingmin Zhao1Yu-Cheng Gu2Lefu Lan3Chang-Yun Wang4Yue-Wei Guo5State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, ChinaSyngenta, Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UKState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, ChinaKey Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, ChinaFour new sesquiterpene hydroquinones, xishaeleganins A–D (<b>6</b>–<b>9</b>), along with eleven known related ones (<b>12</b> and <b>14</b>–<b>23</b>) were isolated from the Xisha marine sponge <i>Dactylospongia elegans</i> (family Thorectida). Their structures were determined by extensive spectroscopic analysis, ECD calculations, and by comparison with the spectral data reported in the literature. Compounds <b>7</b>, <b>15</b>, <b>20</b>, and <b>21</b> showed significant antibacterial activity against <i>Staphylococcus aureus</i>, with minimum inhibitory concentration values of 1.5, 2.9, 5.6, and 5.6 µg/mL, which are comparable with those obtained for the positive control vancomycin (MIC: 1.0 µg/mL).https://www.mdpi.com/1660-3397/20/2/118sponge<i>Dactylospongia elegans</i>Thorectidaantibacterialsesquiterpene hydroquinones |
| spellingShingle | Bao Chen Qingmin Zhao Yu-Cheng Gu Lefu Lan Chang-Yun Wang Yue-Wei Guo Xishaeleganins A–D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge <i>Dactylospongia elegans</i> Marine Drugs sponge <i>Dactylospongia elegans</i> Thorectida antibacterial sesquiterpene hydroquinones |
| title | Xishaeleganins A–D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge <i>Dactylospongia elegans</i> |
| title_full | Xishaeleganins A–D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge <i>Dactylospongia elegans</i> |
| title_fullStr | Xishaeleganins A–D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge <i>Dactylospongia elegans</i> |
| title_full_unstemmed | Xishaeleganins A–D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge <i>Dactylospongia elegans</i> |
| title_short | Xishaeleganins A–D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge <i>Dactylospongia elegans</i> |
| title_sort | xishaeleganins a d sesquiterpenoid hydroquinones from xisha marine sponge i dactylospongia elegans i |
| topic | sponge <i>Dactylospongia elegans</i> Thorectida antibacterial sesquiterpene hydroquinones |
| url | https://www.mdpi.com/1660-3397/20/2/118 |
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