Cognition-associated long noncoding RNAs are dysregulated upon severe COVID-19
Severe COVID-19 leads to widespread transcriptomic changes in the human brain, mimicking diminished cognitive performance. As long noncoding RNAs (lncRNAs) play crucial roles in the regulation of gene expression, identification of the lncRNAs differentially expressed upon COVID-19 may nominate key r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1290523/full |
| _version_ | 1797316797322493952 |
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| author | Jonathan D. Lee Isaac H. Solomon Frank J. Slack Frank J. Slack Maria Mavrikaki Maria Mavrikaki |
| author_facet | Jonathan D. Lee Isaac H. Solomon Frank J. Slack Frank J. Slack Maria Mavrikaki Maria Mavrikaki |
| author_sort | Jonathan D. Lee |
| collection | DOAJ |
| description | Severe COVID-19 leads to widespread transcriptomic changes in the human brain, mimicking diminished cognitive performance. As long noncoding RNAs (lncRNAs) play crucial roles in the regulation of gene expression, identification of the lncRNAs differentially expressed upon COVID-19 may nominate key regulatory nodes underpinning cognitive changes. Here we identify hundreds of lncRNAs differentially expressed in the brains of COVID-19 patients relative to uninfected age/sex-matched controls, many of which are associated with decreased cognitive performance and inflammatory cytokine response. Our analyses reveal pervasive transcriptomic changes in lncRNA expression upon severe COVID-19, which may serve as key regulators of neurocognitive changes in the brain. |
| first_indexed | 2024-03-08T03:24:33Z |
| format | Article |
| id | doaj.art-8e88a92ee8984811be2945ff6ba71bdb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T03:24:33Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8e88a92ee8984811be2945ff6ba71bdb2024-02-12T04:31:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.12905231290523Cognition-associated long noncoding RNAs are dysregulated upon severe COVID-19Jonathan D. Lee0Isaac H. Solomon1Frank J. Slack2Frank J. Slack3Maria Mavrikaki4Maria Mavrikaki5Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesDepartment of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United StatesDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, United StatesDepartment of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United StatesHarvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA, United StatesSevere COVID-19 leads to widespread transcriptomic changes in the human brain, mimicking diminished cognitive performance. As long noncoding RNAs (lncRNAs) play crucial roles in the regulation of gene expression, identification of the lncRNAs differentially expressed upon COVID-19 may nominate key regulatory nodes underpinning cognitive changes. Here we identify hundreds of lncRNAs differentially expressed in the brains of COVID-19 patients relative to uninfected age/sex-matched controls, many of which are associated with decreased cognitive performance and inflammatory cytokine response. Our analyses reveal pervasive transcriptomic changes in lncRNA expression upon severe COVID-19, which may serve as key regulators of neurocognitive changes in the brain.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1290523/fullnoncoding RNAslncRNAscognitive declineCOVID-19frontal cortex |
| spellingShingle | Jonathan D. Lee Isaac H. Solomon Frank J. Slack Frank J. Slack Maria Mavrikaki Maria Mavrikaki Cognition-associated long noncoding RNAs are dysregulated upon severe COVID-19 Frontiers in Immunology noncoding RNAs lncRNAs cognitive decline COVID-19 frontal cortex |
| title | Cognition-associated long noncoding RNAs are dysregulated upon severe COVID-19 |
| title_full | Cognition-associated long noncoding RNAs are dysregulated upon severe COVID-19 |
| title_fullStr | Cognition-associated long noncoding RNAs are dysregulated upon severe COVID-19 |
| title_full_unstemmed | Cognition-associated long noncoding RNAs are dysregulated upon severe COVID-19 |
| title_short | Cognition-associated long noncoding RNAs are dysregulated upon severe COVID-19 |
| title_sort | cognition associated long noncoding rnas are dysregulated upon severe covid 19 |
| topic | noncoding RNAs lncRNAs cognitive decline COVID-19 frontal cortex |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1290523/full |
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