Exploring New Mechanism of Depression from the Effects of Virus on Nerve Cells
Depression is a common neuropsychiatric disorder with long-term recurrent depressed mood, pain and despair, pessimism and anxiety, and even suicidal tendencies as the main symptoms. Depression usually induces or aggravates the development of other related diseases, such as sleep disorders and endocr...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/13/1767 |
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| author | Xinxin Yu Shihao Wang Wenzheng Wu Hongyuan Chang Pufan Shan Lin Yang Wenjie Zhang Xiaoyu Wang |
| author_facet | Xinxin Yu Shihao Wang Wenzheng Wu Hongyuan Chang Pufan Shan Lin Yang Wenjie Zhang Xiaoyu Wang |
| author_sort | Xinxin Yu |
| collection | DOAJ |
| description | Depression is a common neuropsychiatric disorder with long-term recurrent depressed mood, pain and despair, pessimism and anxiety, and even suicidal tendencies as the main symptoms. Depression usually induces or aggravates the development of other related diseases, such as sleep disorders and endocrine disorders. In today’s society, the incidence of depression is increasing worldwide, and its pathogenesis is complex and generally believed to be related to genetic, psychological, environmental, and biological factors. Current studies have shown the key role of glial cells in the development of depression, and it is noteworthy that some recent evidence suggests that the development of depression may be closely related to viral infections, such as SARS-CoV-2, BoDV-1, ZIKV, HIV, and HHV6, which infect the organism and cause some degree of glial cells, such as astrocytes, oligodendrocytes, and microglia. This can affect the transmission of related proteins, neurotransmitters, and cytokines, which in turn leads to neuroinflammation and depression. Based on the close relationship between viruses and depression, this paper provides an in-depth analysis of the new mechanism of virus-induced depression, which is expected to provide a new perspective on the mechanism of depression and a new idea for the diagnosis of depression in the future. |
| first_indexed | 2024-03-11T01:45:17Z |
| format | Article |
| id | doaj.art-8e899c0f95784d6bbeb8a7fda0eb345a |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T01:45:17Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8e899c0f95784d6bbeb8a7fda0eb345a2023-11-18T16:19:45ZengMDPI AGCells2073-44092023-07-011213176710.3390/cells12131767Exploring New Mechanism of Depression from the Effects of Virus on Nerve CellsXinxin Yu0Shihao Wang1Wenzheng Wu2Hongyuan Chang3Pufan Shan4Lin Yang5Wenjie Zhang6Xiaoyu Wang7College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaCollege of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaCollege of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaCollege of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaCollege of Nursing, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaCollege of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, ChinaDepression is a common neuropsychiatric disorder with long-term recurrent depressed mood, pain and despair, pessimism and anxiety, and even suicidal tendencies as the main symptoms. Depression usually induces or aggravates the development of other related diseases, such as sleep disorders and endocrine disorders. In today’s society, the incidence of depression is increasing worldwide, and its pathogenesis is complex and generally believed to be related to genetic, psychological, environmental, and biological factors. Current studies have shown the key role of glial cells in the development of depression, and it is noteworthy that some recent evidence suggests that the development of depression may be closely related to viral infections, such as SARS-CoV-2, BoDV-1, ZIKV, HIV, and HHV6, which infect the organism and cause some degree of glial cells, such as astrocytes, oligodendrocytes, and microglia. This can affect the transmission of related proteins, neurotransmitters, and cytokines, which in turn leads to neuroinflammation and depression. Based on the close relationship between viruses and depression, this paper provides an in-depth analysis of the new mechanism of virus-induced depression, which is expected to provide a new perspective on the mechanism of depression and a new idea for the diagnosis of depression in the future.https://www.mdpi.com/2073-4409/12/13/1767depressionvirusmicrogliaastrocytesoligodendrocytes |
| spellingShingle | Xinxin Yu Shihao Wang Wenzheng Wu Hongyuan Chang Pufan Shan Lin Yang Wenjie Zhang Xiaoyu Wang Exploring New Mechanism of Depression from the Effects of Virus on Nerve Cells Cells depression virus microglia astrocytes oligodendrocytes |
| title | Exploring New Mechanism of Depression from the Effects of Virus on Nerve Cells |
| title_full | Exploring New Mechanism of Depression from the Effects of Virus on Nerve Cells |
| title_fullStr | Exploring New Mechanism of Depression from the Effects of Virus on Nerve Cells |
| title_full_unstemmed | Exploring New Mechanism of Depression from the Effects of Virus on Nerve Cells |
| title_short | Exploring New Mechanism of Depression from the Effects of Virus on Nerve Cells |
| title_sort | exploring new mechanism of depression from the effects of virus on nerve cells |
| topic | depression virus microglia astrocytes oligodendrocytes |
| url | https://www.mdpi.com/2073-4409/12/13/1767 |
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