Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia
Enhanced dopaminergic activity in rodents has been shown to lead to locomotor hyperactivity. MK-801, an NMDA (N-methyl-d-aspartate) receptor antagonist, indirectly activates dopaminergic activity in humans and rodents, and has the ability to induce locomotor hyperactivity. Abnormalities in locomotor...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464613001795 |
| _version_ | 1831544529310711808 |
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| author | Satoshi Okuyama Takahiro Fukata Yuki Nishigawa Yoshiaki Amakura Morio Yoshimura Takashi Yoshida Mitsunari Nakajima Yoshiko Furukawa |
| author_facet | Satoshi Okuyama Takahiro Fukata Yuki Nishigawa Yoshiaki Amakura Morio Yoshimura Takashi Yoshida Mitsunari Nakajima Yoshiko Furukawa |
| author_sort | Satoshi Okuyama |
| collection | DOAJ |
| description | Enhanced dopaminergic activity in rodents has been shown to lead to locomotor hyperactivity. MK-801, an NMDA (N-methyl-d-aspartate) receptor antagonist, indirectly activates dopaminergic activity in humans and rodents, and has the ability to induce locomotor hyperactivity. Abnormalities in locomotor activity are a prominent feature in the positive symptoms of schizophrenia. We showed here that the citrus flavonoid 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF) has a protective effect on hyperactivity induced by MK-801 in the Y-maze test and open field test. These results suggest that HMF has the ability to relieve MK-801-induced schizophrenia positive symptom-like behavior. |
| first_indexed | 2024-12-17T01:11:03Z |
| format | Article |
| id | doaj.art-8e8be1ced6cc474ea39796ecdd3f9985 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T01:11:03Z |
| publishDate | 2013-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8e8be1ced6cc474ea39796ecdd3f99852022-12-21T22:09:08ZengElsevierJournal of Functional Foods1756-46462013-10-015420022006Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophreniaSatoshi Okuyama0Takahiro Fukata1Yuki Nishigawa2Yoshiaki Amakura3Morio Yoshimura4Takashi Yoshida5Mitsunari Nakajima6Yoshiko Furukawa7Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, Japan; Corresponding author. Tel.: +81 89 925 7111; fax: +81 89 926 7162.Department of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, JapanDepartment of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, JapanDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, JapanDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, JapanDepartment of Pharmacognosy, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, JapanDepartment of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, JapanDepartment of Pharmaceutical Pharmacology, College of Pharmaceutical Sciences, Matsuyama University, 4-2 Bunkyo-cho, Matsuyama, Ehime 790-8578, JapanEnhanced dopaminergic activity in rodents has been shown to lead to locomotor hyperactivity. MK-801, an NMDA (N-methyl-d-aspartate) receptor antagonist, indirectly activates dopaminergic activity in humans and rodents, and has the ability to induce locomotor hyperactivity. Abnormalities in locomotor activity are a prominent feature in the positive symptoms of schizophrenia. We showed here that the citrus flavonoid 3,5,6,7,8,3′,4′-heptamethoxyflavone (HMF) has a protective effect on hyperactivity induced by MK-801 in the Y-maze test and open field test. These results suggest that HMF has the ability to relieve MK-801-induced schizophrenia positive symptom-like behavior.http://www.sciencedirect.com/science/article/pii/S1756464613001795HeptamethoxyflavoneMK-801Schizophrenia-like behaviorLocomotionY-maze testOpen field test |
| spellingShingle | Satoshi Okuyama Takahiro Fukata Yuki Nishigawa Yoshiaki Amakura Morio Yoshimura Takashi Yoshida Mitsunari Nakajima Yoshiko Furukawa Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia Journal of Functional Foods Heptamethoxyflavone MK-801 Schizophrenia-like behavior Locomotion Y-maze test Open field test |
| title | Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia |
| title_full | Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia |
| title_fullStr | Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia |
| title_full_unstemmed | Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia |
| title_short | Citrus flavonoid improves MK-801-induced locomotive hyperactivity: Possible relevance to schizophrenia |
| title_sort | citrus flavonoid improves mk 801 induced locomotive hyperactivity possible relevance to schizophrenia |
| topic | Heptamethoxyflavone MK-801 Schizophrenia-like behavior Locomotion Y-maze test Open field test |
| url | http://www.sciencedirect.com/science/article/pii/S1756464613001795 |
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