Monolayer platform to generate and purify primordial germ-like cells in vitro provides insights into human germline specification

Monolayer platform to generate and purify primordial germ-like cells in vitro provides insights into human germline specification

Abstract Generating primordial germ cell-like cells (PGCLCs) from human pluripotent stem cells (hPSCs) advances studies of human reproduction and development of infertility treatments, but often entails complex 3D aggregates. Here we develop a simplified, monolayer method to differentiate hPSCs into...

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Bibliographic Details
Main Authors: Sivakamasundari Vijayakumar, Roberta Sala, Gugene Kang, Angela Chen, Michelle Ann Pablo, Abidemi Ismail Adebayo, Andrea Cipriano, Jonas L. Fowler, Danielle L. Gomes, Lay Teng Ang, Kyle M. Loh, Vittorio Sebastiano
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41302-w

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