Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles
Mesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with potential applications in different therapeutic areas and that have been extensively used as drug carriers in different fields of medicine. The present work is focused on the synthesis of MSNs containing a maleamat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-01-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4923/11/1/30 |
| _version_ | 1828109695735300096 |
|---|---|
| author | Diana Díaz-García Perla R. Ardiles Sanjiv Prashar Antonio Rodríguez-Diéguez Paulina L. Páez Santiago Gómez-Ruiz |
| author_facet | Diana Díaz-García Perla R. Ardiles Sanjiv Prashar Antonio Rodríguez-Diéguez Paulina L. Páez Santiago Gómez-Ruiz |
| author_sort | Diana Díaz-García |
| collection | DOAJ |
| description | Mesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with potential applications in different therapeutic areas and that have been extensively used as drug carriers in different fields of medicine. The present work is focused on the synthesis of MSNs containing a maleamato ligand (MSN-maleamic) and the subsequent coordination of copper(II) ions (MSN-maleamic-Cu) for the exploration of their potential application as antibacterial agents. The Cu-containing nanomaterials have been characterized by different techniques and the preliminary antibacterial effect of the supported maleamato-copper(II) complexes has been tested against two types of bacteria (Gram positive and Gram negative) in different assays to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The biological results showed a moderate antibacterial activity against Escherichia coli which motivated a more detailed study of the antibacterial mechanism of action of the synthesized maleamate-containing nanosystems and whose findings showed oxidative stress generation in bacterial cells. All the prepared nanomaterials were also tested as catalysts in the “solvent free” selective oxidation of benzyl alcohol, to observe if there is a potential correlation between the catalytic oxidation capacity of the materials and the observed oxidative stress in bacteria. This may help in the future, for a more accurate rational design of antibacterial nanosystems, based on their observed catalytic oxidation activity. |
| first_indexed | 2024-04-11T11:07:35Z |
| format | Article |
| id | doaj.art-8e8d968c7e4348b28fd913b63ad4879c |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T11:07:35Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8e8d968c7e4348b28fd913b63ad4879c2022-12-22T04:28:14ZengMDPI AGPharmaceutics1999-49232019-01-011113010.3390/pharmaceutics11010030pharmaceutics11010030Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica NanoparticlesDiana Díaz-García0Perla R. Ardiles1Sanjiv Prashar2Antonio Rodríguez-Diéguez3Paulina L. Páez4Santiago Gómez-Ruiz5Departamento de Biología y Geología, Física y Química Inorgánica, ESCET, Universidad Rey Juan Carlos, Calle Tulipán s/n, E-28933 Móstoles (Madrid), SpainDepartamento de Ciencias Farmacéuticas. Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Ciudad Universitaria, Haya de la Torre y Medina Allende, X5000HUA Córdoba, ArgentinaDepartamento de Biología y Geología, Física y Química Inorgánica, ESCET, Universidad Rey Juan Carlos, Calle Tulipán s/n, E-28933 Móstoles (Madrid), SpainDepartamento de Química Inorgánica, Universidad de Granada, Facultad de Ciencias, Campus de Fuentenueva, Avda. Fuentenueva s/n, E-18071 Granada, SpainDepartamento de Ciencias Farmacéuticas. Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Ciudad Universitaria, Haya de la Torre y Medina Allende, X5000HUA Córdoba, ArgentinaDepartamento de Biología y Geología, Física y Química Inorgánica, ESCET, Universidad Rey Juan Carlos, Calle Tulipán s/n, E-28933 Móstoles (Madrid), SpainMesoporous silica nanoparticles (MSNs) are an interesting class of nanomaterials with potential applications in different therapeutic areas and that have been extensively used as drug carriers in different fields of medicine. The present work is focused on the synthesis of MSNs containing a maleamato ligand (MSN-maleamic) and the subsequent coordination of copper(II) ions (MSN-maleamic-Cu) for the exploration of their potential application as antibacterial agents. The Cu-containing nanomaterials have been characterized by different techniques and the preliminary antibacterial effect of the supported maleamato-copper(II) complexes has been tested against two types of bacteria (Gram positive and Gram negative) in different assays to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The biological results showed a moderate antibacterial activity against Escherichia coli which motivated a more detailed study of the antibacterial mechanism of action of the synthesized maleamate-containing nanosystems and whose findings showed oxidative stress generation in bacterial cells. All the prepared nanomaterials were also tested as catalysts in the “solvent free” selective oxidation of benzyl alcohol, to observe if there is a potential correlation between the catalytic oxidation capacity of the materials and the observed oxidative stress in bacteria. This may help in the future, for a more accurate rational design of antibacterial nanosystems, based on their observed catalytic oxidation activity.http://www.mdpi.com/1999-4923/11/1/30mesoporous silica nanoparticlesmaleamatescopperantibacterialROSoxidation reactions |
| spellingShingle | Diana Díaz-García Perla R. Ardiles Sanjiv Prashar Antonio Rodríguez-Diéguez Paulina L. Páez Santiago Gómez-Ruiz Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles Pharmaceutics mesoporous silica nanoparticles maleamates copper antibacterial ROS oxidation reactions |
| title | Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles |
| title_full | Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles |
| title_fullStr | Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles |
| title_full_unstemmed | Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles |
| title_short | Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles |
| title_sort | preparation and study of the antibacterial applications and oxidative stress induction of copper maleamate functionalized mesoporous silica nanoparticles |
| topic | mesoporous silica nanoparticles maleamates copper antibacterial ROS oxidation reactions |
| url | http://www.mdpi.com/1999-4923/11/1/30 |
| work_keys_str_mv | AT dianadiazgarcia preparationandstudyoftheantibacterialapplicationsandoxidativestressinductionofcoppermaleamatefunctionalizedmesoporoussilicananoparticles AT perlarardiles preparationandstudyoftheantibacterialapplicationsandoxidativestressinductionofcoppermaleamatefunctionalizedmesoporoussilicananoparticles AT sanjivprashar preparationandstudyoftheantibacterialapplicationsandoxidativestressinductionofcoppermaleamatefunctionalizedmesoporoussilicananoparticles AT antoniorodriguezdieguez preparationandstudyoftheantibacterialapplicationsandoxidativestressinductionofcoppermaleamatefunctionalizedmesoporoussilicananoparticles AT paulinalpaez preparationandstudyoftheantibacterialapplicationsandoxidativestressinductionofcoppermaleamatefunctionalizedmesoporoussilicananoparticles AT santiagogomezruiz preparationandstudyoftheantibacterialapplicationsandoxidativestressinductionofcoppermaleamatefunctionalizedmesoporoussilicananoparticles |