A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD
Acute exacerbations of chronic obstructive pulmonary disease (COPD), an acute worsening of respiratory symptoms, generally result in a poor prognosis. Successful prevention and management of such exacerbations is thus important for patient care. Viral infection, primarily with rhinovirus (RV), is th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2011-04-01
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| Series: | Therapeutic Advances in Respiratory Disease |
| Online Access: | https://doi.org/10.1177/1753465810392264 |
| _version_ | 1818056779862376448 |
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| author | Takahiko Sasaki Katsutoshi Nakayama Hiroyasu Yasuda Mutsuo Yamaya |
| author_facet | Takahiko Sasaki Katsutoshi Nakayama Hiroyasu Yasuda Mutsuo Yamaya |
| author_sort | Takahiko Sasaki |
| collection | DOAJ |
| description | Acute exacerbations of chronic obstructive pulmonary disease (COPD), an acute worsening of respiratory symptoms, generally result in a poor prognosis. Successful prevention and management of such exacerbations is thus important for patient care. Viral infection, primarily with rhinovirus (RV), is the foremost cause of exacerbations in COPD patients. Proton pump inhibitors (PPIs) have been reported to inhibit RV infection in human airway epithelial cells in vitro . Furthermore, clinical trials of PPIs in patients with COPD resulted in a reduction in rates of both common cold and COPD exacerbations. In this review, we discuss the significance of COPD exacerbations, summarize a published trial of the effect of low-dose PPIs on COPD exacerbations, and postulate a mechanism for this effect. |
| first_indexed | 2024-12-10T12:34:16Z |
| format | Article |
| id | doaj.art-8e8da1af486642979df85546eb0c5a22 |
| institution | Directory Open Access Journal |
| issn | 1753-4658 1753-4666 |
| language | English |
| last_indexed | 2024-12-10T12:34:16Z |
| publishDate | 2011-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Respiratory Disease |
| spelling | doaj.art-8e8da1af486642979df85546eb0c5a222022-12-22T01:48:43ZengSAGE PublishingTherapeutic Advances in Respiratory Disease1753-46581753-46662011-04-01510.1177/1753465810392264A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPDTakahiko SasakiKatsutoshi NakayamaHiroyasu YasudaMutsuo YamayaAcute exacerbations of chronic obstructive pulmonary disease (COPD), an acute worsening of respiratory symptoms, generally result in a poor prognosis. Successful prevention and management of such exacerbations is thus important for patient care. Viral infection, primarily with rhinovirus (RV), is the foremost cause of exacerbations in COPD patients. Proton pump inhibitors (PPIs) have been reported to inhibit RV infection in human airway epithelial cells in vitro . Furthermore, clinical trials of PPIs in patients with COPD resulted in a reduction in rates of both common cold and COPD exacerbations. In this review, we discuss the significance of COPD exacerbations, summarize a published trial of the effect of low-dose PPIs on COPD exacerbations, and postulate a mechanism for this effect.https://doi.org/10.1177/1753465810392264 |
| spellingShingle | Takahiko Sasaki Katsutoshi Nakayama Hiroyasu Yasuda Mutsuo Yamaya A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD Therapeutic Advances in Respiratory Disease |
| title | A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD |
| title_full | A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD |
| title_fullStr | A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD |
| title_full_unstemmed | A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD |
| title_short | A new strategy with proton pump inhibitors for the prevention of acute exacerbations in COPD |
| title_sort | new strategy with proton pump inhibitors for the prevention of acute exacerbations in copd |
| url | https://doi.org/10.1177/1753465810392264 |
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