COVID-19 Vaccination in Patients with Chronic Liver Disease
Vaccination against SARS-CoV-2 has become a central public health issue, primarily for vulnerable populations such as individuals with Chronic Liver Disease (CLD). Increased COVID-19-related mortality and disease severity has been noted in this subgroup of patients. Severe COVID-19 tends to further...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/14/12/2778 |
| _version_ | 1797454914046132224 |
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| author | Georgios Schinas Eleni Polyzou Fevronia Mitropetrou Aristotelis Pazionis Charalambos Gogos Christos Triantos Karolina Akinosoglou |
| author_facet | Georgios Schinas Eleni Polyzou Fevronia Mitropetrou Aristotelis Pazionis Charalambos Gogos Christos Triantos Karolina Akinosoglou |
| author_sort | Georgios Schinas |
| collection | DOAJ |
| description | Vaccination against SARS-CoV-2 has become a central public health issue, primarily for vulnerable populations such as individuals with Chronic Liver Disease (CLD). Increased COVID-19-related mortality and disease severity has been noted in this subgroup of patients. Severe COVID-19 tends to further deregulate liver function in patients with chronic liver failure or cirrhosis and even reactivate hepatitis in people living with HBV or HCV. In addition, impaired hepatic function leads to several limitations in possible therapeutic interventions. Chronic hepatic dysregulation, along with the underlying cirrhosis-associated immune dysfunction (CAID), leads to a decreased immune response to vaccination that, in turn, may result in reduced efficacy rates and lowered lasting protection. According to current guidelines, timely vaccination and frequent booster shot administration are deemed necessary in this context. Vaccination-related adverse events are mostly mild in nature and similar to those reported in the general population, whereas the incidence of liver injury following vaccination is relatively rare. We aimed to review available evidence and recommendations associated with COVID-19 vaccination in patients with chronic liver disease, and provide insight to current issues and future directions. |
| first_indexed | 2024-03-09T15:44:54Z |
| format | Article |
| id | doaj.art-8e8dcb8d7ceb43bb990d86bba18195b9 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T15:44:54Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-8e8dcb8d7ceb43bb990d86bba18195b92023-11-24T18:39:30ZengMDPI AGViruses1999-49152022-12-011412277810.3390/v14122778COVID-19 Vaccination in Patients with Chronic Liver DiseaseGeorgios Schinas0Eleni Polyzou1Fevronia Mitropetrou2Aristotelis Pazionis3Charalambos Gogos4Christos Triantos5Karolina Akinosoglou6Department of Internal Medicine, University General Hospital of Patras, 26504 Rio, GreeceDepartment of Internal Medicine, University General Hospital of Patras, 26504 Rio, GreeceDepartment of Medicine, University of Patras, 26504 Rio, GreeceDepartment of Medicine, University of Patras, 26504 Rio, GreeceDepartment of Internal Medicine, University General Hospital of Patras, 26504 Rio, GreeceDepartment of Medicine, University of Patras, 26504 Rio, GreeceDepartment of Internal Medicine, University General Hospital of Patras, 26504 Rio, GreeceVaccination against SARS-CoV-2 has become a central public health issue, primarily for vulnerable populations such as individuals with Chronic Liver Disease (CLD). Increased COVID-19-related mortality and disease severity has been noted in this subgroup of patients. Severe COVID-19 tends to further deregulate liver function in patients with chronic liver failure or cirrhosis and even reactivate hepatitis in people living with HBV or HCV. In addition, impaired hepatic function leads to several limitations in possible therapeutic interventions. Chronic hepatic dysregulation, along with the underlying cirrhosis-associated immune dysfunction (CAID), leads to a decreased immune response to vaccination that, in turn, may result in reduced efficacy rates and lowered lasting protection. According to current guidelines, timely vaccination and frequent booster shot administration are deemed necessary in this context. Vaccination-related adverse events are mostly mild in nature and similar to those reported in the general population, whereas the incidence of liver injury following vaccination is relatively rare. We aimed to review available evidence and recommendations associated with COVID-19 vaccination in patients with chronic liver disease, and provide insight to current issues and future directions.https://www.mdpi.com/1999-4915/14/12/2778COVID-19 vaccinesmRNA vaccinechronic liver diseaseimmunizationSARS-CoV-2 |
| spellingShingle | Georgios Schinas Eleni Polyzou Fevronia Mitropetrou Aristotelis Pazionis Charalambos Gogos Christos Triantos Karolina Akinosoglou COVID-19 Vaccination in Patients with Chronic Liver Disease Viruses COVID-19 vaccines mRNA vaccine chronic liver disease immunization SARS-CoV-2 |
| title | COVID-19 Vaccination in Patients with Chronic Liver Disease |
| title_full | COVID-19 Vaccination in Patients with Chronic Liver Disease |
| title_fullStr | COVID-19 Vaccination in Patients with Chronic Liver Disease |
| title_full_unstemmed | COVID-19 Vaccination in Patients with Chronic Liver Disease |
| title_short | COVID-19 Vaccination in Patients with Chronic Liver Disease |
| title_sort | covid 19 vaccination in patients with chronic liver disease |
| topic | COVID-19 vaccines mRNA vaccine chronic liver disease immunization SARS-CoV-2 |
| url | https://www.mdpi.com/1999-4915/14/12/2778 |
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