Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles
Colon cancer poses a complex and substantial global health challenge, necessitating innovative therapeutic approaches. Chalcones, a versatile class of compounds with diverse pharmacological properties, have emerged as promising candidates for addressing colon cancer. Their ability to modulate pivota...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/12/2718 |
| _version_ | 1797379656973811712 |
|---|---|
| author | Soufyane Hba Suzan Ghaddar Hicham Wahnou Aline Pinon Riad El Kebbaj Christelle Pouget Vincent Sol Bertrand Liagre Mounia Oudghiri Youness Limami |
| author_facet | Soufyane Hba Suzan Ghaddar Hicham Wahnou Aline Pinon Riad El Kebbaj Christelle Pouget Vincent Sol Bertrand Liagre Mounia Oudghiri Youness Limami |
| author_sort | Soufyane Hba |
| collection | DOAJ |
| description | Colon cancer poses a complex and substantial global health challenge, necessitating innovative therapeutic approaches. Chalcones, a versatile class of compounds with diverse pharmacological properties, have emerged as promising candidates for addressing colon cancer. Their ability to modulate pivotal signaling pathways in the development and progression of colon cancer makes them invaluable as targeted therapeutics. Nevertheless, it is crucial to recognize that although chalcones exhibit promise, further pre-clinical studies are required to validate their efficacy and safety. The journey toward effective colon cancer treatment is multifaceted, involving considerations such as optimizing the sequencing of therapeutic agents, comprehending the resistance mechanisms, and exploring combination therapies incorporating chalcones. Furthermore, the integration of nanoparticle-based drug delivery systems presents a novel avenue for enhancing the effectiveness of chalcones in colon cancer treatment. This review delves into the mechanisms of action of natural chalcones and some derivatives. It highlights the challenges associated with their use in pre-clinical studies, while also underscoring the advantages of employing chalcone-based nanoparticles for the treatment of colon cancer. |
| first_indexed | 2024-03-08T20:27:07Z |
| format | Article |
| id | doaj.art-8e8ebe922f4341db83aed45676e6c9b6 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-08T20:27:07Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8e8ebe922f4341db83aed45676e6c9b62023-12-22T14:32:06ZengMDPI AGPharmaceutics1999-49232023-12-011512271810.3390/pharmaceutics15122718Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based NanoparticlesSoufyane Hba0Suzan Ghaddar1Hicham Wahnou2Aline Pinon3Riad El Kebbaj4Christelle Pouget5Vincent Sol6Bertrand Liagre7Mounia Oudghiri8Youness Limami9Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P 2693 Maarif, Casablanca 20100, MoroccoUniv. Limoges, LABCiS, UR 22722, F-87000 Limoges, FranceLaboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P 2693 Maarif, Casablanca 20100, MoroccoUniv. Limoges, LABCiS, UR 22722, F-87000 Limoges, FranceLaboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University of Settat, Settat 26000, MoroccoUniv. Limoges, LABCiS, UR 22722, F-87000 Limoges, FranceUniv. Limoges, LABCiS, UR 22722, F-87000 Limoges, FranceUniv. Limoges, LABCiS, UR 22722, F-87000 Limoges, FranceLaboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P 2693 Maarif, Casablanca 20100, MoroccoLaboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P 2693 Maarif, Casablanca 20100, MoroccoColon cancer poses a complex and substantial global health challenge, necessitating innovative therapeutic approaches. Chalcones, a versatile class of compounds with diverse pharmacological properties, have emerged as promising candidates for addressing colon cancer. Their ability to modulate pivotal signaling pathways in the development and progression of colon cancer makes them invaluable as targeted therapeutics. Nevertheless, it is crucial to recognize that although chalcones exhibit promise, further pre-clinical studies are required to validate their efficacy and safety. The journey toward effective colon cancer treatment is multifaceted, involving considerations such as optimizing the sequencing of therapeutic agents, comprehending the resistance mechanisms, and exploring combination therapies incorporating chalcones. Furthermore, the integration of nanoparticle-based drug delivery systems presents a novel avenue for enhancing the effectiveness of chalcones in colon cancer treatment. This review delves into the mechanisms of action of natural chalcones and some derivatives. It highlights the challenges associated with their use in pre-clinical studies, while also underscoring the advantages of employing chalcone-based nanoparticles for the treatment of colon cancer.https://www.mdpi.com/1999-4923/15/12/2718natural chalconescolon cancerchalcones-based nanoparticlesdrug delivery system |
| spellingShingle | Soufyane Hba Suzan Ghaddar Hicham Wahnou Aline Pinon Riad El Kebbaj Christelle Pouget Vincent Sol Bertrand Liagre Mounia Oudghiri Youness Limami Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles Pharmaceutics natural chalcones colon cancer chalcones-based nanoparticles drug delivery system |
| title | Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles |
| title_full | Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles |
| title_fullStr | Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles |
| title_full_unstemmed | Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles |
| title_short | Natural Chalcones and Derivatives in Colon Cancer: Pre-Clinical Challenges and the Promise of Chalcone-Based Nanoparticles |
| title_sort | natural chalcones and derivatives in colon cancer pre clinical challenges and the promise of chalcone based nanoparticles |
| topic | natural chalcones colon cancer chalcones-based nanoparticles drug delivery system |
| url | https://www.mdpi.com/1999-4923/15/12/2718 |
| work_keys_str_mv | AT soufyanehba naturalchalconesandderivativesincoloncancerpreclinicalchallengesandthepromiseofchalconebasednanoparticles AT suzanghaddar naturalchalconesandderivativesincoloncancerpreclinicalchallengesandthepromiseofchalconebasednanoparticles AT hichamwahnou naturalchalconesandderivativesincoloncancerpreclinicalchallengesandthepromiseofchalconebasednanoparticles AT alinepinon naturalchalconesandderivativesincoloncancerpreclinicalchallengesandthepromiseofchalconebasednanoparticles AT riadelkebbaj naturalchalconesandderivativesincoloncancerpreclinicalchallengesandthepromiseofchalconebasednanoparticles AT christellepouget naturalchalconesandderivativesincoloncancerpreclinicalchallengesandthepromiseofchalconebasednanoparticles AT vincentsol naturalchalconesandderivativesincoloncancerpreclinicalchallengesandthepromiseofchalconebasednanoparticles AT bertrandliagre naturalchalconesandderivativesincoloncancerpreclinicalchallengesandthepromiseofchalconebasednanoparticles AT mouniaoudghiri naturalchalconesandderivativesincoloncancerpreclinicalchallengesandthepromiseofchalconebasednanoparticles AT younesslimami naturalchalconesandderivativesincoloncancerpreclinicalchallengesandthepromiseofchalconebasednanoparticles |