Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT<sub>2C</sub> Agonists

Synthesis and Biological Evaluation of Disubstituted Pyrimidines as Selective 5-HT<sub>2C</sub> Agonists

Here, we describe the synthesis of disubstituted pyrimidine derivatives and their biological evaluation as selective 5-HT<sub>2C</sub> agonists. To improve selectivity for 5-HT<sub>2C</sub> over other subtypes, we synthesized two series of disubstituted pyrimidines with fluor...

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Bibliographic Details
Main Authors:	Juhyeon Kim, Yoon Jung Kim, Ashwini M. Londhe, Ae Nim Pae, Hyunah Choo, Hak Joong Kim, Sun-Joon Min
Format:	Article
Language:	English
Published:	MDPI AG 2019-09-01
Series:	Molecules
Subjects:	disubstituted pyrimidine 5-HT<sub>2C</sub> receptor cell-based assay binding affinity selectivity
Online Access:	https://www.mdpi.com/1420-3049/24/18/3234

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