Determination of Inorganic Ions in Parenteral Nutrition Solutions by Ion Chromatography
A new, simple and sensitive ion chromatography (IC) method for the determination of sodium, potassium, magnesium, calcium and chloride in a parenteral nutrition (PN) solution was developed and validated. Before sample analysis, a sample pretreatment by calcination was applied which could totally rem...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/16/5266 |
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| author | Zhiqi Wen Kris Wolfs Ann Van Schepdael Erwin Adams |
| author_facet | Zhiqi Wen Kris Wolfs Ann Van Schepdael Erwin Adams |
| author_sort | Zhiqi Wen |
| collection | DOAJ |
| description | A new, simple and sensitive ion chromatography (IC) method for the determination of sodium, potassium, magnesium, calcium and chloride in a parenteral nutrition (PN) solution was developed and validated. Before sample analysis, a sample pretreatment by calcination was applied which could totally remove interference from other constituents of the PN solution. Methanesulfonic acid (MSA) and sodium hydroxide were used as the mobile phase for the determination of cations and anions, respectively. The calibration curves showed good correlation between analyte peak area and concentration (r<sup>2</sup> > 0.999). Detection limits ranged from 0.0001 to 0.02 mg/L and quantification limits from 0.0002 to 0.06 mg/L. Relative standard deviation (RSD) values for repeatability and inter-day precision did not exceed 1.0% and the recoveries for all analytes were between 99.1–101.1%. The robustness was verified by using an experimental design. |
| first_indexed | 2024-03-09T09:52:02Z |
| format | Article |
| id | doaj.art-8e95a69a0d144dc7a640cc788eab7940 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T09:52:02Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8e95a69a0d144dc7a640cc788eab79402023-12-02T00:04:55ZengMDPI AGMolecules1420-30492022-08-012716526610.3390/molecules27165266Determination of Inorganic Ions in Parenteral Nutrition Solutions by Ion ChromatographyZhiqi Wen0Kris Wolfs1Ann Van Schepdael2Erwin Adams3Pharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, BelgiumPharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, BelgiumPharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, BelgiumPharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, BelgiumA new, simple and sensitive ion chromatography (IC) method for the determination of sodium, potassium, magnesium, calcium and chloride in a parenteral nutrition (PN) solution was developed and validated. Before sample analysis, a sample pretreatment by calcination was applied which could totally remove interference from other constituents of the PN solution. Methanesulfonic acid (MSA) and sodium hydroxide were used as the mobile phase for the determination of cations and anions, respectively. The calibration curves showed good correlation between analyte peak area and concentration (r<sup>2</sup> > 0.999). Detection limits ranged from 0.0001 to 0.02 mg/L and quantification limits from 0.0002 to 0.06 mg/L. Relative standard deviation (RSD) values for repeatability and inter-day precision did not exceed 1.0% and the recoveries for all analytes were between 99.1–101.1%. The robustness was verified by using an experimental design.https://www.mdpi.com/1420-3049/27/16/5266parenteral nutritionsample pretreatmentinorganic ionsion chromatography |
| spellingShingle | Zhiqi Wen Kris Wolfs Ann Van Schepdael Erwin Adams Determination of Inorganic Ions in Parenteral Nutrition Solutions by Ion Chromatography Molecules parenteral nutrition sample pretreatment inorganic ions ion chromatography |
| title | Determination of Inorganic Ions in Parenteral Nutrition Solutions by Ion Chromatography |
| title_full | Determination of Inorganic Ions in Parenteral Nutrition Solutions by Ion Chromatography |
| title_fullStr | Determination of Inorganic Ions in Parenteral Nutrition Solutions by Ion Chromatography |
| title_full_unstemmed | Determination of Inorganic Ions in Parenteral Nutrition Solutions by Ion Chromatography |
| title_short | Determination of Inorganic Ions in Parenteral Nutrition Solutions by Ion Chromatography |
| title_sort | determination of inorganic ions in parenteral nutrition solutions by ion chromatography |
| topic | parenteral nutrition sample pretreatment inorganic ions ion chromatography |
| url | https://www.mdpi.com/1420-3049/27/16/5266 |
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