The Straw That Broke the Camel’s Back: Natural Variations in 17β-Estradiol and COMT-Val158Met Genotype Interact in the Modulation of Model-Free and Model-Based Control

The Straw That Broke the Camel’s Back: Natural Variations in 17β-Estradiol and COMT-Val158Met Genotype Interact in the Modulation of Model-Free and Model-Based Control

The sex hormone estradiol has recently gained attention in human decision-making research. Animal studies have already shown that estradiol promotes dopaminergic transmission and thus supports reward-seeking behavior and aspects of addiction. In humans, natural variations of estradiol across the men...

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Bibliographic Details
Main Authors: Esther K. Diekhof, Andra Geana, Frederike Ohm, Bradley B. Doll, Michael J. Frank
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
reinforcement learning
estrogen
menstrual cycle
dopamine
reward learning
reward volatility
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2021.658769/full

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