Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection
Abstract Hepatitis B virus (HBV) infection is one of the most common causes of viral hepatitis worldwide. Patients with persistent HBV infection may suffer from liver cirrhosis, hepatocellular carcinoma or hepatic failure. In this review, we mainly discuss the immunotherapy for HBV infection. At pre...
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Clinical and Translational Discovery |
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| Online Access: | https://doi.org/10.1002/ctd2.173 |
| _version_ | 1811158675353501696 |
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| author | Xuejie Wu Feng Xu |
| author_facet | Xuejie Wu Feng Xu |
| author_sort | Xuejie Wu |
| collection | DOAJ |
| description | Abstract Hepatitis B virus (HBV) infection is one of the most common causes of viral hepatitis worldwide. Patients with persistent HBV infection may suffer from liver cirrhosis, hepatocellular carcinoma or hepatic failure. In this review, we mainly discuss the immunotherapy for HBV infection. At present, drugs against HBV include oral nucleos(t)ide analogues and interferon. It is difficult to achieve the loss of hepatitis B surface antigen which is an ideal treatment endpoint in patients with chronic hepatitis B (CHB) using the currently recommended agents. There is a need for additional effective therapies among which immunotherapy may be a promising option. Dendritic cells (DCs) exert a key role in initiating the adaptive immune response that could determine the outcome of HBV infection. DC‐based immunotherapy has been explored in chronic HBV infection and shows some promising results. We conclude that DC‐based immunotherapy may be a potential therapeutic option for chronic HBV infection. |
| first_indexed | 2024-04-10T05:28:09Z |
| format | Article |
| id | doaj.art-8e96d752396942a9bb18032737ce58b0 |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-04-10T05:28:09Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-8e96d752396942a9bb18032737ce58b02023-03-07T10:05:45ZengWileyClinical and Translational Discovery2768-06222023-02-0131n/an/a10.1002/ctd2.173Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infectionXuejie Wu0Feng Xu1Department of Infectious Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou ChinaDepartment of Infectious Diseases The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou ChinaAbstract Hepatitis B virus (HBV) infection is one of the most common causes of viral hepatitis worldwide. Patients with persistent HBV infection may suffer from liver cirrhosis, hepatocellular carcinoma or hepatic failure. In this review, we mainly discuss the immunotherapy for HBV infection. At present, drugs against HBV include oral nucleos(t)ide analogues and interferon. It is difficult to achieve the loss of hepatitis B surface antigen which is an ideal treatment endpoint in patients with chronic hepatitis B (CHB) using the currently recommended agents. There is a need for additional effective therapies among which immunotherapy may be a promising option. Dendritic cells (DCs) exert a key role in initiating the adaptive immune response that could determine the outcome of HBV infection. DC‐based immunotherapy has been explored in chronic HBV infection and shows some promising results. We conclude that DC‐based immunotherapy may be a potential therapeutic option for chronic HBV infection.https://doi.org/10.1002/ctd2.173adaptive immune responsechronic hepatitis Bdendritic cellshepatitis B virusimmunotherapy |
| spellingShingle | Xuejie Wu Feng Xu Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection Clinical and Translational Discovery adaptive immune response chronic hepatitis B dendritic cells hepatitis B virus immunotherapy |
| title | Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection |
| title_full | Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection |
| title_fullStr | Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection |
| title_full_unstemmed | Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection |
| title_short | Dendritic cell‐based immunotherapy: A potential therapeutic option for chronic Hepatitis B virus infection |
| title_sort | dendritic cell based immunotherapy a potential therapeutic option for chronic hepatitis b virus infection |
| topic | adaptive immune response chronic hepatitis B dendritic cells hepatitis B virus immunotherapy |
| url | https://doi.org/10.1002/ctd2.173 |
| work_keys_str_mv | AT xuejiewu dendriticcellbasedimmunotherapyapotentialtherapeuticoptionforchronichepatitisbvirusinfection AT fengxu dendriticcellbasedimmunotherapyapotentialtherapeuticoptionforchronichepatitisbvirusinfection |