Human induced pluripotent stem cells (hiPSCs) derived cells reflect tissue specificity found in patients with Leigh syndrome French Canadian variant (LSFC)

Human induced pluripotent stem cells (hiPSCs) derived cells reflect tissue specificity found in patients with Leigh syndrome French Canadian variant (LSFC)

Leigh syndrome French Canadian type (LSFC) is a recessive neurodegenerative disease characterized by tissue-specific deficiency in cytochrome c oxidase (COX), the fourth complex in the oxidative phosphorylation system. LSFC is caused by mutations in the leucine rich pentatricopeptide repeat containi...

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Bibliographic Details
Main Authors: Roselle Gélinas, Chloé Lévesque, Julie Thompson Legault, Marie-Eve Rivard, Louis Villeneuve, Catherine Laprise, John D. Rioux
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Genetics
Subjects:
induced pluripotent stem cells
three germ layers
hepatocyte-like cells
cardiomyocyte cells
disease modeling
Leigh syndrome French Canadian type
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1375467/full

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