Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases
Herein, we report the clinico-tomographic and histopathological features of four patients with biopsy-proven ocular surface squamous epithelial hyperplasia (OSSEH), a close mimicker of ocular surface squamous neoplasia (OSSN). The mean age at diagnosis was 58 years (median, 60 years; range, 35–77 ye...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Oman Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ojoonline.org/article.asp?issn=0974-620X;year=2023;volume=16;issue=2;spage=314;epage=317;aulast=Vempuluru |
| _version_ | 1797773688352800768 |
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| author | Vijitha S Vempuluru Neha Ghose Saumya Jakati Swathi Kaliki |
| author_facet | Vijitha S Vempuluru Neha Ghose Saumya Jakati Swathi Kaliki |
| author_sort | Vijitha S Vempuluru |
| collection | DOAJ |
| description | Herein, we report the clinico-tomographic and histopathological features of four patients with biopsy-proven ocular surface squamous epithelial hyperplasia (OSSEH), a close mimicker of ocular surface squamous neoplasia (OSSN). The mean age at diagnosis was 58 years (median, 60 years; range, 35–77 years). All lesions were unilateral. Isolated corneal plaque was seen in 50% (n = 2) and nodular lesion at the nasal limbus in 50% (n = 2). Keratinization was seen in 75% (n = 3) of lesions and intrinsic vessels in 75% (n = 3). A clinical diagnosis of OSSN was made in all cases. Anterior segment optical coherence tomography (ASOCT) revealed mild epithelial hyperreflectivity in 100% (n = 4). The epithelium was normal in thickness in 75% (n = 3) and showed mild thickening in 25% (n = 1). Only 25% (n = 1) showed abrupt transition in epithelial thickness from the contiguous corneal epithelium. Histopathological examination revealed hyperplastic squamous epithelium and no cellular atypia in all cases. Stable ocular surface and no recurrences were noted at a mean follow-up of 17 months (median, 11 months; range, 2–43 months). Although OSSEH can mimic OSSN clinically, the presence of mild epithelial hyperreflectivity, lack of epithelial thickening, absence of abrupt transition from normal epithelium, and presence of subepithelial hyperreflectivity on ASOCT favor the diagnosis of OSSEH. |
| first_indexed | 2024-03-12T22:09:11Z |
| format | Article |
| id | doaj.art-8e994ab1575f480c877bc4a896cd23d1 |
| institution | Directory Open Access Journal |
| issn | 0974-620X |
| language | English |
| last_indexed | 2024-03-12T22:09:11Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Oman Journal of Ophthalmology |
| spelling | doaj.art-8e994ab1575f480c877bc4a896cd23d12023-07-23T16:12:46ZengWolters Kluwer Medknow PublicationsOman Journal of Ophthalmology0974-620X2023-01-0116231431710.4103/ojo.ojo_173_22Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four casesVijitha S VempuluruNeha GhoseSaumya JakatiSwathi KalikiHerein, we report the clinico-tomographic and histopathological features of four patients with biopsy-proven ocular surface squamous epithelial hyperplasia (OSSEH), a close mimicker of ocular surface squamous neoplasia (OSSN). The mean age at diagnosis was 58 years (median, 60 years; range, 35–77 years). All lesions were unilateral. Isolated corneal plaque was seen in 50% (n = 2) and nodular lesion at the nasal limbus in 50% (n = 2). Keratinization was seen in 75% (n = 3) of lesions and intrinsic vessels in 75% (n = 3). A clinical diagnosis of OSSN was made in all cases. Anterior segment optical coherence tomography (ASOCT) revealed mild epithelial hyperreflectivity in 100% (n = 4). The epithelium was normal in thickness in 75% (n = 3) and showed mild thickening in 25% (n = 1). Only 25% (n = 1) showed abrupt transition in epithelial thickness from the contiguous corneal epithelium. Histopathological examination revealed hyperplastic squamous epithelium and no cellular atypia in all cases. Stable ocular surface and no recurrences were noted at a mean follow-up of 17 months (median, 11 months; range, 2–43 months). Although OSSEH can mimic OSSN clinically, the presence of mild epithelial hyperreflectivity, lack of epithelial thickening, absence of abrupt transition from normal epithelium, and presence of subepithelial hyperreflectivity on ASOCT favor the diagnosis of OSSEH.http://www.ojoonline.org/article.asp?issn=0974-620X;year=2023;volume=16;issue=2;spage=314;epage=317;aulast=Vempuluruanterior segment optical coherence tomographyeyeocular surfaceocular surface squamous neoplasiapseudo-ocular surface squamous neoplasiasquamous epithelial hyperplasia |
| spellingShingle | Vijitha S Vempuluru Neha Ghose Saumya Jakati Swathi Kaliki Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases Oman Journal of Ophthalmology anterior segment optical coherence tomography eye ocular surface ocular surface squamous neoplasia pseudo-ocular surface squamous neoplasia squamous epithelial hyperplasia |
| title | Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases |
| title_full | Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases |
| title_fullStr | Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases |
| title_full_unstemmed | Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases |
| title_short | Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases |
| title_sort | anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia a report of four cases |
| topic | anterior segment optical coherence tomography eye ocular surface ocular surface squamous neoplasia pseudo-ocular surface squamous neoplasia squamous epithelial hyperplasia |
| url | http://www.ojoonline.org/article.asp?issn=0974-620X;year=2023;volume=16;issue=2;spage=314;epage=317;aulast=Vempuluru |
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