Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review
Abstract In the light of growing global epidemic of type 2 diabetes mellitus (T2DM), significant efforts are made to discover next-generation biomarkers for early detection of the disease. Multiple mechanisms including inflammatory response, abnormal insulin secretion and glucose metabolism contribu...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-08-01
|
| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12933-019-0918-x |
| _version_ | 1831717118723227648 |
|---|---|
| author | Justyna Pordzik Daniel Jakubik Joanna Jarosz-Popek Zofia Wicik Ceren Eyileten Salvatore De Rosa Ciro Indolfi Jolanta M. Siller-Matula Pamela Czajka Marek Postula |
| author_facet | Justyna Pordzik Daniel Jakubik Joanna Jarosz-Popek Zofia Wicik Ceren Eyileten Salvatore De Rosa Ciro Indolfi Jolanta M. Siller-Matula Pamela Czajka Marek Postula |
| author_sort | Justyna Pordzik |
| collection | DOAJ |
| description | Abstract In the light of growing global epidemic of type 2 diabetes mellitus (T2DM), significant efforts are made to discover next-generation biomarkers for early detection of the disease. Multiple mechanisms including inflammatory response, abnormal insulin secretion and glucose metabolism contribute to the development of T2DM. Platelet activation, on the other hand, is known to be one of the underlying mechanisms of atherosclerosis, which is a common T2DM complication that frequently results in ischemic events at later stages of the disease. Available data suggest that platelets contain large amounts of microRNAs (miRNAs) that are found in circulating body fluids, including the blood. Since miRNAs have been illustrated to play an important role in metabolic homeostasis through regulation of multiple genes, they attracted substantial scientific interest as diagnostic and prognostic biomarkers in T2DM. Various miRNAs, as well as their target genes are implicated in the complex pathophysiology of T2DM. This article will first review the different miRNAs studied in the context of T2DM and platelet reactivity, and subsequently present original results from bioinformatic analyses of published reports, identifying a common gene (PRKAR1A) linked to glucose metabolism, blood coagulation and insulin signalling and targeted by miRNAs in T2DM. Moreover, miRNA–target gene interaction networks built upon Gene Ontology information from electronic databases were developed. According to our results, miR-30a-5p, miR-30d-5p and miR-30c-5p are the most widely regulated miRNAs across all specified ontologies, hence they are the most promising biomarkers of T2DM to be investigated in future clinical studies. |
| first_indexed | 2024-12-21T00:52:20Z |
| format | Article |
| id | doaj.art-8e9cc054277849699a96ac40b9b31fa4 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-21T00:52:20Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-8e9cc054277849699a96ac40b9b31fa42022-12-21T19:21:22ZengBMCCardiovascular Diabetology1475-28402019-08-0118111910.1186/s12933-019-0918-xSignificance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and reviewJustyna Pordzik0Daniel Jakubik1Joanna Jarosz-Popek2Zofia Wicik3Ceren Eyileten4Salvatore De Rosa5Ciro Indolfi6Jolanta M. Siller-Matula7Pamela Czajka8Marek Postula9Department of Experimental and Clinical Pharmacology, Center for Preclinical Research and Technology CEPT, Medical University of WarsawDepartment of Experimental and Clinical Pharmacology, Center for Preclinical Research and Technology CEPT, Medical University of WarsawDepartment of Experimental and Clinical Pharmacology, Center for Preclinical Research and Technology CEPT, Medical University of WarsawRheumatology Division, Hospital das Clinicas HCFMUSP, University of São Paulo, School of MedicineDepartment of Experimental and Clinical Pharmacology, Center for Preclinical Research and Technology CEPT, Medical University of WarsawDivision of Cardiology, Department of Medical and Surgical Sciences, “Magna Graecia” UniversityDivision of Cardiology, Department of Medical and Surgical Sciences, “Magna Graecia” UniversityDepartment of Cardiology, Medical University of ViennaDepartment of Experimental and Clinical Pharmacology, Center for Preclinical Research and Technology CEPT, Medical University of WarsawDepartment of Experimental and Clinical Pharmacology, Center for Preclinical Research and Technology CEPT, Medical University of WarsawAbstract In the light of growing global epidemic of type 2 diabetes mellitus (T2DM), significant efforts are made to discover next-generation biomarkers for early detection of the disease. Multiple mechanisms including inflammatory response, abnormal insulin secretion and glucose metabolism contribute to the development of T2DM. Platelet activation, on the other hand, is known to be one of the underlying mechanisms of atherosclerosis, which is a common T2DM complication that frequently results in ischemic events at later stages of the disease. Available data suggest that platelets contain large amounts of microRNAs (miRNAs) that are found in circulating body fluids, including the blood. Since miRNAs have been illustrated to play an important role in metabolic homeostasis through regulation of multiple genes, they attracted substantial scientific interest as diagnostic and prognostic biomarkers in T2DM. Various miRNAs, as well as their target genes are implicated in the complex pathophysiology of T2DM. This article will first review the different miRNAs studied in the context of T2DM and platelet reactivity, and subsequently present original results from bioinformatic analyses of published reports, identifying a common gene (PRKAR1A) linked to glucose metabolism, blood coagulation and insulin signalling and targeted by miRNAs in T2DM. Moreover, miRNA–target gene interaction networks built upon Gene Ontology information from electronic databases were developed. According to our results, miR-30a-5p, miR-30d-5p and miR-30c-5p are the most widely regulated miRNAs across all specified ontologies, hence they are the most promising biomarkers of T2DM to be investigated in future clinical studies.http://link.springer.com/article/10.1186/s12933-019-0918-xMicroRNADiabetes mellitus type 2Platelet reactivityBiomarkerBioinformatic analysismiRNA–gene target interaction |
| spellingShingle | Justyna Pordzik Daniel Jakubik Joanna Jarosz-Popek Zofia Wicik Ceren Eyileten Salvatore De Rosa Ciro Indolfi Jolanta M. Siller-Matula Pamela Czajka Marek Postula Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review Cardiovascular Diabetology MicroRNA Diabetes mellitus type 2 Platelet reactivity Biomarker Bioinformatic analysis miRNA–gene target interaction |
| title | Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review |
| title_full | Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review |
| title_fullStr | Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review |
| title_full_unstemmed | Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review |
| title_short | Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review |
| title_sort | significance of circulating micrornas in diabetes mellitus type 2 and platelet reactivity bioinformatic analysis and review |
| topic | MicroRNA Diabetes mellitus type 2 Platelet reactivity Biomarker Bioinformatic analysis miRNA–gene target interaction |
| url | http://link.springer.com/article/10.1186/s12933-019-0918-x |
| work_keys_str_mv | AT justynapordzik significanceofcirculatingmicrornasindiabetesmellitustype2andplateletreactivitybioinformaticanalysisandreview AT danieljakubik significanceofcirculatingmicrornasindiabetesmellitustype2andplateletreactivitybioinformaticanalysisandreview AT joannajaroszpopek significanceofcirculatingmicrornasindiabetesmellitustype2andplateletreactivitybioinformaticanalysisandreview AT zofiawicik significanceofcirculatingmicrornasindiabetesmellitustype2andplateletreactivitybioinformaticanalysisandreview AT cereneyileten significanceofcirculatingmicrornasindiabetesmellitustype2andplateletreactivitybioinformaticanalysisandreview AT salvatorederosa significanceofcirculatingmicrornasindiabetesmellitustype2andplateletreactivitybioinformaticanalysisandreview AT ciroindolfi significanceofcirculatingmicrornasindiabetesmellitustype2andplateletreactivitybioinformaticanalysisandreview AT jolantamsillermatula significanceofcirculatingmicrornasindiabetesmellitustype2andplateletreactivitybioinformaticanalysisandreview AT pamelaczajka significanceofcirculatingmicrornasindiabetesmellitustype2andplateletreactivitybioinformaticanalysisandreview AT marekpostula significanceofcirculatingmicrornasindiabetesmellitustype2andplateletreactivitybioinformaticanalysisandreview |