Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity
Mandrup et al. describe a panel of recombinant albumin fusions, engineered with different affinities to the human neonatal Fc receptor to program the half-life extension of a bispecific (EGFR/CD3) T-cell engager. They show that this approach generates target engagement, T-cell activation, tunable in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-01790-2 |
| _version_ | 1818420785932402688 |
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| author | Ole A. Mandrup Sui Ching Ong Simon Lykkemark Anders Dinesen Imke Rudnik-Jansen Niels Frederik Dagnæs-Hansen Jan Terje Andersen Luis Alvarez-Vallina Kenneth A. Howard |
| author_facet | Ole A. Mandrup Sui Ching Ong Simon Lykkemark Anders Dinesen Imke Rudnik-Jansen Niels Frederik Dagnæs-Hansen Jan Terje Andersen Luis Alvarez-Vallina Kenneth A. Howard |
| author_sort | Ole A. Mandrup |
| collection | DOAJ |
| description | Mandrup et al. describe a panel of recombinant albumin fusions, engineered with different affinities to the human neonatal Fc receptor to program the half-life extension of a bispecific (EGFR/CD3) T-cell engager. They show that this approach generates target engagement, T-cell activation, tunable in vivo half-life extension, cellular cytotoxicity dependent on the cell surface levels of EGFR and can inhibit growth of BRAF mutated EGFR-positive tumours in mice. |
| first_indexed | 2024-12-14T12:59:59Z |
| format | Article |
| id | doaj.art-8e9de18872a44db2b4a88a0afeac0789 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T12:59:59Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-8e9de18872a44db2b4a88a0afeac07892022-12-21T23:00:28ZengNature PortfolioCommunications Biology2399-36422021-03-014111110.1038/s42003-021-01790-2Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinityOle A. Mandrup0Sui Ching Ong1Simon Lykkemark2Anders Dinesen3Imke Rudnik-Jansen4Niels Frederik Dagnæs-Hansen5Jan Terje Andersen6Luis Alvarez-Vallina7Kenneth A. Howard8Interdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics, Aarhus UniversityInterdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics, Aarhus UniversityInterdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics, Aarhus UniversityInterdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics, Aarhus UniversityInterdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics, Aarhus UniversityDepartment of Biomedicine, Aarhus UniversityDepartment of Immunology, University of Oslo, Oslo University Hospital RikshospitaletCancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de OctubreInterdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology and Genetics, Aarhus UniversityMandrup et al. describe a panel of recombinant albumin fusions, engineered with different affinities to the human neonatal Fc receptor to program the half-life extension of a bispecific (EGFR/CD3) T-cell engager. They show that this approach generates target engagement, T-cell activation, tunable in vivo half-life extension, cellular cytotoxicity dependent on the cell surface levels of EGFR and can inhibit growth of BRAF mutated EGFR-positive tumours in mice.https://doi.org/10.1038/s42003-021-01790-2 |
| spellingShingle | Ole A. Mandrup Sui Ching Ong Simon Lykkemark Anders Dinesen Imke Rudnik-Jansen Niels Frederik Dagnæs-Hansen Jan Terje Andersen Luis Alvarez-Vallina Kenneth A. Howard Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity Communications Biology |
| title | Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity |
| title_full | Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity |
| title_fullStr | Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity |
| title_full_unstemmed | Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity |
| title_short | Programmable half-life and anti-tumour effects of bispecific T-cell engager-albumin fusions with tuned FcRn affinity |
| title_sort | programmable half life and anti tumour effects of bispecific t cell engager albumin fusions with tuned fcrn affinity |
| url | https://doi.org/10.1038/s42003-021-01790-2 |
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