Pharmacological brake-release of mRNA translation enhances cognitive memory

Pharmacological brake-release of mRNA translation enhances cognitive memory

Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions activate different eIF2α kinases (PERK, PKR, GCN2, and HRI) that converge on phosphorylating a unique serine in eIF2α. This collection of signali...

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Bibliografiska uppgifter
Huvudupphovsmän:	Carmela Sidrauski, Diego Acosta-Alvear, Arkady Khoutorsky, Punitha Vedantham, Brian R Hearn, Han Li, Karine Gamache, Ciara M Gallagher, Kenny K-H Ang, Chris Wilson, Voytek Okreglak, Avi Ashkenazi, Byron Hann, Karim Nader, Michelle R Arkin, Adam R Renslo, Nahum Sonenberg, Peter Walter
Materialtyp:	Artikel
Språk:	English
Publicerad:	eLife Sciences Publications Ltd 2013-05-01
Serie:	eLife
Ämnen:	eIF2 eIF2B ATF4 integrated stress response unfolded protein response memory consolidation
Länkar:	https://elifesciences.org/articles/00498

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